Sep 2, 2022·edited Sep 2, 2022Liked by Walter M Chesnut
Much appreciated, Walter! Your identification of the role of the mitochondrial permeability transition pore (mPTP) and the ability of metformin to help it stay closed to protect the mitochondria should enable those who learn of it help themselves and their patients reduce the damage caused by these (apparent bioweapon) spike proteins. I will do what I can to spread the word.
So, how are you going to get your GP to prescribe a drug you don't need, because you're not diabetic, to prevent harm they're not going to believe is happening?
Another essential nutrient w up to 20% UK/USA population deficient tyvm factory food is B12 but doubtful MDs test for levels when the long list of common vague symptoms present.
Vitamin deficiency anemia usually develops slowly over several months to years. Signs and symptoms may be subtle at first but usually increase as the deficiency worsens. These may include:
Agree with this!! WebMD notes people over age 50 should take a daily B12 supplement. I do myself and encourage my patients to do so as it is very safe. Also note PPI drugs like Prilosec interfere with B12 absorption so anyone taking those meds ought to get a periodic B12 blood level.
Awesome we knew you should be on the favorites MD list. Another little known fact for supplement fans is that Vitamin C depletes the B12 so they should be taken 4+ hours apart. :~)
Wow I did not know that pearl about vit C and B12–thank you!!! Prilosec also interferes with magnesium absorption and I think there are likely some other bad effects from long term use—kinda like most or all prescription drugs—best to avoid whenever you can. Metformin has been around for decades—it fell out of favor for diabetes a while when a shiny new brand came along—I think it was TZDs for diabetes. But these drugs have been linked to bladder cancer. I try to NOT be an early adopter of new drugs—sometimes hard as patients can be enthralled by the TV ads. Fortunately the readers of this Substack are probably appropriately skeptical of any Big Pharma new things!
Wow! This is excellent deep dive we need to unravel this witches brew of spike protein. May I add a couple of points. Mitochondria are gram negative bacteria that have their own mItogenome, separate from ours and activate Toll like receptors when they break up, which produce the netosis from leukocytes. Berberine is Metformin-like in its ability to regulate calcium homeostasis in mDNA, see Dr. Finny Varghese, nih.gov. Obatollex also prevents apoptosis.
This is beyond my capacity to comprehend fully. Yet, I remember seeing somewhere that calcium buildup was observed in the placenta of pregnant women after vaccination. I wonder if it is related to what's discussed here.
“Intracellular oxidative stress induced by calcium influx initiates the activation of phagocytosis in keratinocytes accumulating at S-phase of the cell cycle after UVB irradiation”
“Dr. Wolf summarized a video interview in which Dr. Thorp presented a picture of a placenta of a woman who was in her third trimester of pregnancy and had received the Pfizer Covid vaccine 8 weeks prior. He said this is not uncommon in placentas 8 weeks post-vaccination, and he’s noticing a pattern of this state of the placenta. There’s a netting of calcification that’s not meant to be there. The white area surrounding the placenta lobes represents calcifications from serious inflammation. Typically this finding is associated with the slowing of the growth of the fetus, reduced amniotic fluid volume, and abnormal fetal surveillance testing. The dark circle on the right may be indicative of a blood clot.”
This goes over and beyond my level of understanding. But I am intrigued.
I still think of mitochondria as sort of like little tiny petrol generators that produce energy for the cell.
And cells are just little tiny protein factories that work independently to produce, package and distribute proteins for whatever function that particular cell is responsible for.
I am a 55 y/o female who rec'd a dx of Psoriatic Arthritis (similar to rheumatoid arthritis) just prior to getting co19 Jan 2021. I was started soon after co19 on Methotrexate. I noticed a pretty rapid deterioration in a number of things post co19 which is hard to determine whether it was post (long) covid or PSA but one of them is definitely aging. I have run a lot through PubMed on the effects of Methotrexate and the liver and found anecdotal evidence there that high levels of vit C, resveratrol, NAC and Omegas help prevent fibrosis of the liver due to the damage of the methotrexate. I have since gone off methotrexate as my symptoms have leveled out. I am also on Hydroxychloroquine. I wonder if you go down that trail you might find some things that help get rid or slow the cytokine storm/fibrosis. Also high levels of folate help the red blood cells to repair DNA. I am looking into DHEA, PQQ, COQ10, taurine, quercetin and A-Lipoic acid to help DNA repair. I have also been on PPIs and note that is probably a terrible thing to be on as it also advances aging. Anyhow, I wanted to share what I have found. Thank you for all the time you have devoted to this.
So are you saying mitophagy (death of the mitochondria) due to excess Ca2+ lead to epithelial cell apoptosis? Don't we want damaged mitochondria to undergo mitophagy in order to promote healthy mitochondria in a cell? Or does this process cause total destruction of all mitochondria and that is why you want to stop it?
What if the mitochondria don't know they're broken? So the mitophagy doesn't occur as it should.
Imagine an old engine and its old carburetor that is no longer tuned correctly. Combustion in the engine still happens. It's the fuel and oxygen ratio that is a bit unbalanced. So it backfires and splutters and puts out a lot of smoke. But it works... Sort of.
In keeping with the hypothesis that many different forms of lethal cellular and molecular action were built into the SARS-CoV-2 bioweapon structure, including HIV, furin cleavage site etc., I'm wondering if they also used information known about the mechanisms of cystic fibrosis to incorporate relevant sequences and promote cystic fibrosis-like results in the lungs.
Maybe someone has already looked at the cystic fibrosis connection, but I haven't seen it come up by name yet in my own research trawling - Just passing it along in case it's a useful line of investigation for you.
Thank you, Wondrous Walter, for another stellar report!
Thank you for finding and kindly sharing information about Metformin relative, most importantly, to the mitochondria.
In its repertoire of virtuosity, Metformin is also able to induce autophagy, as I believe that Dr. Marik has discussed; .
And here is a three year old study which "sheds light" on Metformin as an anti-prion candidate ascribed to its anti-prion capability.Definitely, we should ESCHEW SUGAR!
This study "sheds light" on metformin as an anti-prion candidate for the combination therapy of prion diseases. Biochem Biophys Res Commun. 2020 Mar 5;523(2):423-428. doi: 10.1016/j.bbrc.2019.12.074. Epub 2019 Dec 23.
Metformin reduces prion infection in neuronal cells by enhancing autophagy
Much appreciated, Walter! Your identification of the role of the mitochondrial permeability transition pore (mPTP) and the ability of metformin to help it stay closed to protect the mitochondria should enable those who learn of it help themselves and their patients reduce the damage caused by these (apparent bioweapon) spike proteins. I will do what I can to spread the word.
So, how are you going to get your GP to prescribe a drug you don't need, because you're not diabetic, to prevent harm they're not going to believe is happening?
I don't work with MDs who don't work for me. If necessary, I'd find another source for something as innocuous and widely available as metformin.
What would be the dosage and for how long? Would it work for those who had the disease months ago?
I’ve shared this! Thanks.
but practically speaking for the layman, what do you do? quercetin, curcumin, B12?
Berberine
Metformin natural alternative: B12. Also used to treat radiation poisoning. Hmmmm. https://www.webmd.com/vitamins/condition-1863/metformin-related-vitamin-b12-deficiency
Another essential nutrient w up to 20% UK/USA population deficient tyvm factory food is B12 but doubtful MDs test for levels when the long list of common vague symptoms present.
Vitamin deficiency anemia usually develops slowly over several months to years. Signs and symptoms may be subtle at first but usually increase as the deficiency worsens. These may include:
Fatigue
Shortness of breath
Dizziness
Pale or yellowish skin
Irregular heartbeats
Weight loss
Numbness or tingling in the hands and feet
Muscle weakness
Personality changes
Unsteady movements
Mental confusion or forgetfulness
https://www.mayoclinic.org/diseases-conditions/vitamin-deficiency-anemia/symptoms-causes/syc-20355025
Agree with this!! WebMD notes people over age 50 should take a daily B12 supplement. I do myself and encourage my patients to do so as it is very safe. Also note PPI drugs like Prilosec interfere with B12 absorption so anyone taking those meds ought to get a periodic B12 blood level.
Awesome we knew you should be on the favorites MD list. Another little known fact for supplement fans is that Vitamin C depletes the B12 so they should be taken 4+ hours apart. :~)
Wow I did not know that pearl about vit C and B12–thank you!!! Prilosec also interferes with magnesium absorption and I think there are likely some other bad effects from long term use—kinda like most or all prescription drugs—best to avoid whenever you can. Metformin has been around for decades—it fell out of favor for diabetes a while when a shiny new brand came along—I think it was TZDs for diabetes. But these drugs have been linked to bladder cancer. I try to NOT be an early adopter of new drugs—sometimes hard as patients can be enthralled by the TV ads. Fortunately the readers of this Substack are probably appropriately skeptical of any Big Pharma new things!
Thank-you for the link!
Wow! This is excellent deep dive we need to unravel this witches brew of spike protein. May I add a couple of points. Mitochondria are gram negative bacteria that have their own mItogenome, separate from ours and activate Toll like receptors when they break up, which produce the netosis from leukocytes. Berberine is Metformin-like in its ability to regulate calcium homeostasis in mDNA, see Dr. Finny Varghese, nih.gov. Obatollex also prevents apoptosis.
Another useful analysis, with a practical remedy to try. Thanks.
This is beyond my capacity to comprehend fully. Yet, I remember seeing somewhere that calcium buildup was observed in the placenta of pregnant women after vaccination. I wonder if it is related to what's discussed here.
Meta-analysis of 19 studies showed that metformin is associated with 34% lower COVID-19 mortality. https://www.frontiersin.org/articles/10.3389/fmed.2021.704666/full Any suggestions for dosage?
The mitochondria are the Stars in the cell!
Apoptosis and uvb
https://en.wikipedia.org/wiki/UVB-induced_apoptosis
Metformin
“Metformin effect on driving cell survival pathway through inhibition of UVB-induced ROS formation”
https://pubmed.ncbi.nlm.nih.gov/33080281/
Calcium influx
“Intracellular oxidative stress induced by calcium influx initiates the activation of phagocytosis in keratinocytes accumulating at S-phase of the cell cycle after UVB irradiation”
https://www.sciencedirect.com/science/article/abs/pii/S0923181121001365
“UVB irradiation-induced dysregulation of plasma membrane calcium ATPase1 and intracellular calcium homeostasis in human lens epithelial cells”
https://pubmed.ncbi.nlm.nih.gov/23817774/
As above so below, as within so without!
Is berberin a good alternative?
Yes. See Dr. Finny Varghese, nih.gov
Thanks!
“Dr. Wolf summarized a video interview in which Dr. Thorp presented a picture of a placenta of a woman who was in her third trimester of pregnancy and had received the Pfizer Covid vaccine 8 weeks prior. He said this is not uncommon in placentas 8 weeks post-vaccination, and he’s noticing a pattern of this state of the placenta. There’s a netting of calcification that’s not meant to be there. The white area surrounding the placenta lobes represents calcifications from serious inflammation. Typically this finding is associated with the slowing of the growth of the fetus, reduced amniotic fluid volume, and abnormal fetal surveillance testing. The dark circle on the right may be indicative of a blood clot.”
https://etana.substack.com/p/vaccinated-placentas
our bodies use calcium as a band aid over inflammation. Thats why they measure calcium in heart CTs.
Makes sense.
And why we need K2 when we take calcium to usher it into our bones not arteries and everywhere we have inflammation.
This goes over and beyond my level of understanding. But I am intrigued.
I still think of mitochondria as sort of like little tiny petrol generators that produce energy for the cell.
And cells are just little tiny protein factories that work independently to produce, package and distribute proteins for whatever function that particular cell is responsible for.
look at mTOR pathways and consider spike proteins suppress p53 protein and how metformin interacts w/ mTOR
Hmmm...
I am a 55 y/o female who rec'd a dx of Psoriatic Arthritis (similar to rheumatoid arthritis) just prior to getting co19 Jan 2021. I was started soon after co19 on Methotrexate. I noticed a pretty rapid deterioration in a number of things post co19 which is hard to determine whether it was post (long) covid or PSA but one of them is definitely aging. I have run a lot through PubMed on the effects of Methotrexate and the liver and found anecdotal evidence there that high levels of vit C, resveratrol, NAC and Omegas help prevent fibrosis of the liver due to the damage of the methotrexate. I have since gone off methotrexate as my symptoms have leveled out. I am also on Hydroxychloroquine. I wonder if you go down that trail you might find some things that help get rid or slow the cytokine storm/fibrosis. Also high levels of folate help the red blood cells to repair DNA. I am looking into DHEA, PQQ, COQ10, taurine, quercetin and A-Lipoic acid to help DNA repair. I have also been on PPIs and note that is probably a terrible thing to be on as it also advances aging. Anyhow, I wanted to share what I have found. Thank you for all the time you have devoted to this.
So are you saying mitophagy (death of the mitochondria) due to excess Ca2+ lead to epithelial cell apoptosis? Don't we want damaged mitochondria to undergo mitophagy in order to promote healthy mitochondria in a cell? Or does this process cause total destruction of all mitochondria and that is why you want to stop it?
What if the mitochondria don't know they're broken? So the mitophagy doesn't occur as it should.
Imagine an old engine and its old carburetor that is no longer tuned correctly. Combustion in the engine still happens. It's the fuel and oxygen ratio that is a bit unbalanced. So it backfires and splutters and puts out a lot of smoke. But it works... Sort of.
Just noticed that one of the authors on the 2015 Menachery paper, Scott Randell, is affiliated with the Cystic Fibrosis Center at UNC-Chapel Hill.
https://www.nature.com/articles/nm.3985
In keeping with the hypothesis that many different forms of lethal cellular and molecular action were built into the SARS-CoV-2 bioweapon structure, including HIV, furin cleavage site etc., I'm wondering if they also used information known about the mechanisms of cystic fibrosis to incorporate relevant sequences and promote cystic fibrosis-like results in the lungs.
Maybe someone has already looked at the cystic fibrosis connection, but I haven't seen it come up by name yet in my own research trawling - Just passing it along in case it's a useful line of investigation for you.
Thank you for your hard work!
Thank you, Wondrous Walter, for another stellar report!
Thank you for finding and kindly sharing information about Metformin relative, most importantly, to the mitochondria.
In its repertoire of virtuosity, Metformin is also able to induce autophagy, as I believe that Dr. Marik has discussed; .
And here is a three year old study which "sheds light" on Metformin as an anti-prion candidate ascribed to its anti-prion capability.Definitely, we should ESCHEW SUGAR!
https://pubmed.ncbi.nlm.nih.gov/31874705/
This study "sheds light" on metformin as an anti-prion candidate for the combination therapy of prion diseases. Biochem Biophys Res Commun. 2020 Mar 5;523(2):423-428. doi: 10.1016/j.bbrc.2019.12.074. Epub 2019 Dec 23.
Metformin reduces prion infection in neuronal cells by enhancing autophagy
...and there's a reason why my grandmother knew NO DAIRY during a cold.