Tin et al., Published A Paper Yesterday (8/11/24) Confirming My March 2022 Hypothesis that the Spike Protein Induces Cardiac Fibrosis
Yet, there is good news and hope in that NLRP3 inhibitors found in our Friday Hope series attenuate this effect.
As readers of this Substack know, I have long hypothesized and warned that the Spike Protein of SARS-CoV-2 induces systemic fibrosis. This has been proven in a paper published yesterday in Cells. It found that the fibrosis is triggered in precisely the way I hypothesized it would be – paralleling radiation. The Spike Protein activates the NLRP3/Nf-KB inflammasome inducing ECM synthesis.
Mechanisms underlying S1 protein-induced activation of CFs and promotion of ECM protein synthesis. Key processes involve activation of the NLRP3 inflammasome, ACE2/NF-κB signaling, and ROS formation. Upon binding to ACE2, the S1 protein initiates a signaling cascade that activates NF-κB, a transcription factor promoting the expression of inflammation-related genes, including those required for NLRP3 inflammasome and pro-interleukin (IL)-1β. ROS formation triggers NLRP3 inflammasome activation, leading to processing of pro-IL-1β into its mature form by caspase-1. Mature IL-1β is released extracellularly, binds to its receptor, and initiates a signaling cascade, enhancing TGF-β1 production, promoting CFs activation, and inducing ECM synthesis, ultimately contributing to cardiac fibrosis. Abbreviations: SARS-CoV-2: severe acute respiratory syndrome coronary virus 2, CFs: cardiac fibroblasts, ECM: extra cellular matrix, EMT: epithelial-mesenchymal transition, NLRP3: NLR family pyrin domain containing 3, ACE2: angiotensin converting enzyme 2, NF-κB: nuclear factor kappa-light-chain-enhancer of activated B cells, ROS: reactive oxygen species, IL-1β: Interleukin 1 beta.
Spike Protein of SARS-CoV-2 Activates Cardiac Fibrogenesis through NLRP3 Inflammasomes and NF-κB Signaling
https://www.mdpi.com/2073-4409/13/16/1331#
And, here is my post hypothesizing this from 2022:
https://x.com/Parsifaler/status/1501273193322979332
The same published on my research site:
Spike Protein Fibrosis Syndrome
https://wmcresearch.org/spike-protein-fibrosis-syndrome/
However, there is some good news and hope here. The therapeutics I hypothesized in our Friday Hope series which would attenuate this condition, most likely will.
Moreover, NLRP3 (MCC950) and NF-kB inhibitors, but not the TLR4 inhibitor TAK-242, prevented the S1-enhanced CFs migration and overexpression of collagen 1, TGF-β1, and IL-1β.
Spike Protein of SARS-CoV-2 Activates Cardiac Fibrogenesis through NLRP3 Inflammasomes and NF-κB Signaling
https://www.mdpi.com/2073-4409/13/16/1331#
Here are the relevant Friday Hope posts:
Friday Hope: Cinnamon: Cinnamaldehyde as Adjuvant Therapy for COVID/Spike Protein Inflammation
https://wmcresearch.substack.com/p/friday-hope-cinnamon-cinnamaldehyde
Friday Hope: ß-Hydroxybutyrate (BHB): Amyloid Inhibition and Improved Mitochondrial Function
https://wmcresearch.substack.com/p/friday-hope-hydroxybutyrate-bhb-amyloid
Friday Hope: Caffeine: Blood-Brain Barrier Protection and SARS-CoV-2 Therapeutic Properties
https://wmcresearch.substack.com/p/friday-hope-caffeine-blood-brain
Friday Hope: Vitamin K: A Necessary Complement to Vitamin D with Therapeutic Effects for COVID
https://wmcresearch.substack.com/p/friday-hope-vitamin-k-a-necessary
Please remember that this is a work of medical research and not medical advice. Please consult your Primary Care Provider before using any medication of supplement.
It has been an honor and a privilege to report my findings to you. I will continue research of this protein and virus to find deeper understanding and therapeutic solutions.
Thanks Walter. Remember the Spike NTD has a galectin-3 fold. Inhibitors include fenugreek, aspirin, modified citrus pectin, and a few others.
Nb. Gal-3 leads to fibrosis.
Galectin-3 Plays an Important Pro-inflammatory Role in the Induction Phase of Acute Colitis by Promoting Activation of NLRP3 Inflammasome and Production of IL-1β in Macrophages
Bojana Simovic Markovic et al. J Crohns Colitis. 2016 May.
https://pubmed.ncbi.nlm.nih.gov/26786981/
Curious….total layman’s perspective/question here….I am a breast cancer survivor. Implants were placed in my body following a mastectomy. What happens is one’s body “encapsulates” the foreign object. Hence, the implants are essentially encased in scar tissue and a capsule that forms.
Am wondering….in the case of the jab, is it that the fibrous tissue developing in organs or systems flooded with the spike protein an example of the body reacting to and trying to stop the invader…..with the problem being that the invader is lodged within organs or there are cells trained now to make a protein they would not normally make and so the body begins the process of trying to wall off the abnormal activity….resulting in the development of fibrous/scar tissue.