At the very outset the creation of an autoantigen seemed a very, very bad idea indeed. Thank you for helping flesh out the details where the devil resides.
"However, several factors, such as patient current age and weight, were shown to increase the risk of progressing to SPMS (1, 65). Interestingly, CD38 dictates age- and weight-related decline in NAD+ pools (63, 64), and inhibition of CD38 activity in a chronic high-fat consumption model associated with demyelination reduced astrocyte proinflammatory phenotype and improved myelin regeneration. In addition, we recently found a significant (20 ± 4.9%; P = 0.044, by Mann–Whitney test) up-regulation of NAMPT levels in astrocytes of progressive MS patients (62). "
"Importantly, careful consideration should be given to NAD+ supplementation during CNS neuroinflammation, as elevated NAD+ could both support recovery and improve the cell bioenergetics, but also boost CD38-mediated pathogenic pathways. In this regard, nicotinamide supplement is of interest, as it will not only be taken by NAMPT to generate NAD+, but it also has an inherit ability to inhibit CD38 activity. Consistent with this notion, nicotinamide administration was shown to increase spinal cord NAD+ levels, reduce cell infiltration to the CNS, halt demyelination and axonal loss, and ameliorate the clinical course of EAE (73). However, additional clinical and preclinical studies are required to address this unmet clinical need."
Is there anything you can take for NAD depletion? My husband is being treated for ALS even though there has not been a definitive diagnosis by the best doctors in the Northeast. I am not convinced he has this disease. He developed severe fasciculations over the upper half of his body after Covid infection. He is unvexed. Yes I developed some arthritic nodes on his knuckles. He now has some weakness and his left foot. He has severe fatigue one year after infection. he was treated for long Covid with ivermectin and intermittent fasting with very few carbs allowed.He was prescribed Nattokinase but I took it off because of the knuckle problem
At the very outset the creation of an autoantigen seemed a very, very bad idea indeed. Thank you for helping flesh out the details where the devil resides.
They knew what they were doing Walter . The discussion with Kevin McCairn was great . Thanks Walter!
Thank you Walter. Your conversation with Kevin McCairn was excellent. Thanks for all the great information you are discovering. Peace.
This is only secondary because of the prion thing, right?
Prion-like Domains in Spike Protein of SARS-CoV-2 Differ across Its Variants and Enable Changes in Affinity to ACE2
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878784/
Seems like we need to try to treat prions.
We need to remember that spike protein damage, endotoxin/LPS damage, microRNA and dsDNA damage, and LNP damage are ALL going on at once.
There are most likely individual differences in which causes the most damage in that person.
In that regard, ranking which is most bad is probably not useful.
yeah lots of layers, but some could impact much larger populations
LNP damage is not transmissible.. (maybe LNPs are.. tho)
This is similar to CD38 pathogenicity that causes NAD depletion and age onset. Wow!
https://www.pnas.org/doi/10.1073/pnas.2211310119
"However, several factors, such as patient current age and weight, were shown to increase the risk of progressing to SPMS (1, 65). Interestingly, CD38 dictates age- and weight-related decline in NAD+ pools (63, 64), and inhibition of CD38 activity in a chronic high-fat consumption model associated with demyelination reduced astrocyte proinflammatory phenotype and improved myelin regeneration. In addition, we recently found a significant (20 ± 4.9%; P = 0.044, by Mann–Whitney test) up-regulation of NAMPT levels in astrocytes of progressive MS patients (62). "
"Importantly, careful consideration should be given to NAD+ supplementation during CNS neuroinflammation, as elevated NAD+ could both support recovery and improve the cell bioenergetics, but also boost CD38-mediated pathogenic pathways. In this regard, nicotinamide supplement is of interest, as it will not only be taken by NAMPT to generate NAD+, but it also has an inherit ability to inhibit CD38 activity. Consistent with this notion, nicotinamide administration was shown to increase spinal cord NAD+ levels, reduce cell infiltration to the CNS, halt demyelination and axonal loss, and ameliorate the clinical course of EAE (73). However, additional clinical and preclinical studies are required to address this unmet clinical need."
Is there anything you can take for NAD depletion? My husband is being treated for ALS even though there has not been a definitive diagnosis by the best doctors in the Northeast. I am not convinced he has this disease. He developed severe fasciculations over the upper half of his body after Covid infection. He is unvexed. Yes I developed some arthritic nodes on his knuckles. He now has some weakness and his left foot. He has severe fatigue one year after infection. he was treated for long Covid with ivermectin and intermittent fasting with very few carbs allowed.He was prescribed Nattokinase but I took it off because of the knuckle problem
Apigenin is the active ingredient of Parsley. It is excellent for NAD depletion.
Thank you!
https://www.youtube.com/watch?v=7FtBAr5sG8k
What role if any do the available antivirals play?!
So this takes place in some people regardless of vax status.
:(
Thought so.
Thanks for all you do.
https://www.youtube.com/watch?v=zgnITtuv2Hs
The vaxx-spike seems to have a tag for the ER. Could this be called murder on intent in this context?
https://berthub.eu/articles/posts/reverse-engineering-source-code-of-the-biontech-pfizer-vaccine/