THE PURPOSE OF THE FURIN CLEAVAGE SITE AND THE GP120 INSERT IS TO INDUCE SYSTEMIC FIBROSIS AND CANCER VIA THE ENDOTHELIUM: SPED GP120 AND FURIN. THE FURIN FEEDBACK LOOP. FIBROSIS AND ONCOGENESIS.
THE PURPOSE OF THE FURIN CLEAVAGE SITE AND THE GP120 INSERT IS TO INDUCE SYSTEMIC FIBROSIS AND CANCER VIA THE ENDOTHELIUM: SPED GP120 AND FURIN. THE FURIN FEEDBACK LOOP. FIBROSIS AND ONCOGENESIS.
wmcresearch.substack.com
FURIN expression as the unifying determinant of COVID-19 and Spike Protein pathology severity and pathogenesis
Cited supra is a Round Table with stellar participants, including Walter Chesnut, J. C. Couey, Jessica Rose, Spartacus, and Charles Rixey
.The whole Round Table is almost five hours.
Start at ONE MINUTE
Wondrous Walter, the masters' master brilliant puzzler's ever evolving theory is that we are being damaged by SPIKE INJURY ENDOTHELIAL DISEASE Thus, autoimmunity and prion disease are derived from repetitive injuries.
Start at ONE HOUR THIRTY FOUR MINUTES for his two new discoveries relative to endothelial damage.
Analogizing it to Paraquat poisoning, the blood gas barrier in the lungs is being damaged by endothelial damage and oxygen can not be pumped in. NOT PNEUMONIA. The treatment was all wrong.
The heterogeneity of autoimmune disease subsequent to exposure to the spike protein or the virus is due to repeated injury. Damaged tissue induces autoimmune disease. Whether a person will get what autoimmune disease is heterogeneously dependent on which individual's tissue has suffered repeated injuries and auto-antibodies. Similarly, in the manner of TBI - traumatic brain injury - repeated injury is concurrent with prion disease.Skip through the entire Round Table for compelling discussions
.MY COMPLAINT: MORE WALTER! I wanted to hear more, more, more from Walter!!!!I am hoping that Walter will soon be interviewed again by J C Couey. These are wonderful interviews! PLEASE, PLEASE, PLEASE!!
There was a cystic fibrosis expert on the 2015 Menachery/Baric team that designed SARS-CoV-2 with NIH/NIAID/US-AID and Chinese funding.
Among the authors of the paper bioweapons expert Francis A Boyle calls the smoking gun that should be the cornerstone of criminal prosecutions, was Scott Randell of UNC-Chapel Hill cystic fibrosis center. Along with Wayne Marasco, expert on cancer immunology and AIDS at Harvard.
Menachery/Baric paper in Nature Medicine: SARS-like Cluster of Circulating Bat Coronaviruses Pose Threat for Human Emergence.
Authors and contributors identified in the paper were working at the University of North Carolina, Harvard, US Food and Drug Administration (FDA), Wuhan Institute of Virology and Bellinzona Institute of Microbiology in Switzerland:
Vineet D Menachery, Boyd L Yount Jr, Kari Debbink, Lisa E Gralinski, Jessica A Plante, Rachel L Graham, Trevor Scobey, Eric F Donaldson & Ralph S Baric - Department of Epidemiology, University of North Carolina at Chapel Hill
Kari Debbink & Ralph S Baric - Department of Microbiology and Immunology, University of North Carolina at Chapel Hill.
Sudhakar Agnihothram - National Center for Toxicological Research, Food and Drug Administration, US Department of Health and Human Services, Jefferson, Arkansas
Xing-Yi Ge & Zhengli-Li Shi - Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China
Scott H Randell - Department of Cell Biology and Physiology and Cystic Fibrosis Center, Marsico Lung Institute, University of North Carolina at Chapel Hill
Antonio Lanzavecchia - Institute for Research in Biomedicine, Bellinzona Institute of Microbiology, Zurich, Switzerland
Wayne A Marasco - Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston
Financial support from US NIH-NIAID; NIH National Institute of Aging; NIH National Institute of Diabetes and Digestive and Kidney Disease; US-Agency for International Development through EcoHealth Alliance; and China’s National Natural Science Foundation:
National Institute of Allergy & Infectious Disease and the National Institute of Aging of the US National Institutes of Health (NIH) under awards U19AI109761 (R.S.B.), U19AI107810 (R.S.B.), AI085524 (W.A.M.), F32AI102561 (V.D.M.) and K99AG049092 (V.D.M.)
National Natural Science Foundation of China awards 81290341 (Z.-L.S.) and 31470260 (X.-Y.G.), and
USAID-Emerging Pandemic Threats (EPT)-PREDICT funding from EcoHealth Alliance (Z.-L.S.).
Human airway epithelial cultures were supported by the National Institute of Diabetes and Digestive and Kidney Disease of the NIH under award NIH DK065988 (S.H.R.).
M.T. Ferris (Dept. of Genetics, University of North Carolina) reviewed statistical approaches.
C.T. Tseng (Dept. of Microbiology and Immunology, University of Texas Medical Branch) provided Calu-3 cells.
Roots of the program probably lie in sequence of Congressional acts initiated in 1969 to authorize DOD chemical and biological weapons experiments on soldiers, set up the Special Virus Program within the National Cancer Institute at the NIH, and establish global depopulation — executed quietly and with plausible deniability — as a core American-led, globalist geopolitical strategy.
They were looking for a communicable virus that could cause or accelerate cancer and otherwise shorten lives.
This may be far out sounding but I watched a vid where the physician being interviewed was saying they believed that they had evidence that the inbred families at the top of the food chain on this planet, the elite as it were, have designed this spike protein in such a way that it does not bind to their version of ACE2 and therefore can not harm THEM. Watching King Charles haphazardly cavorting with and touching all the prols mindlessly packed in around Buckingham Palace during Mum's hideous spectacle would make you wonder. All these people now seem unconcerned, if they ever were, about any of this. What do they know that we don't?
Many coronaviruses present furin cleavage sites. Notably, in the two human coronaviruses in Alphacoronavirus causing common cold, HCoV NL63 has furin cleavage site at spike S2, and this does not have oncogenic properties. However, this furin cleavage site enhances the transmissibility as well as the tropism of the virus to a plethora of cells.
Maybe this is also related to the sticky blood-clots. According to Ryan Cole they contain white bloodcells glued together via intercellular adhesion molecules. Maybe this is the pathway via which this process gets activated.
WHY ARE DOCTORS & LAWYERS & ALL OTHERS WHO CAN DO SOMETHING ABOUT STOPPING THE SO CALLED VACCINES NOT STOPPING THEM? EVEN WITH ALL THE EVIDENCE STACKING UP, THEY ARR STILL PUSHING THE POISON!
Walter, I'll contribute to this by mentioning what I've been looking into -- the arginine repeats that likely stem from HIV-1 Tat research. Tat / GP120 are contributors to e.g. neuropathology in HIV. Syncytia-building and extracellular matrix disturbance via MMPs etc. can be provoked by the arginine motif, which could culminate in giant clot gobs found in autopsy and/or disturbance of electrical signaling required to keep us alive (sudden death).
As wonder material graphene ascends in the Nanocosm through the pioneering research of Professor James Tour at Rice University and the commercialization efforts of spin-off companies like LIGC and Universal Matter, researchers at the University of Colorado in Boulder, led by Chemistry Professor Wei Zhang, recently made a breakthrough in synthesizing another carbon nanomaterial called graphyne. The pioneering development was published earlier this year in the journal, Nature Synthesis.
Graphyne and its family (which includes graphdiyne, a material first synthesized in 2018 and viewed as having promising potential in a range of commercial applications, including gas separation, catalysis, water remediation, humidity sensor, and energy-related fields.) is a carbon allotrope in 2D form with both sp and sp2 hybridization. You may recall from your chemistry classes that hybridization is defined as the concept of mixing two atomic orbitals to give rise to a new type of hybridized orbitals.
The intermixing process typically results in the formation of hybrid orbitals having entirely different energies, shapes, etc. The carbon atom forms four single bonds wherein the valence-shell s orbital mixes with three valence-shell p orbitals. This combination leads to the formation of four equivalent sp3 mixtures. These will have a tetrahedral arrangement around the carbon which is bonded to four different atoms. Sp hybridization is observed when one s and one p orbital in the same main shell of an atom mix to form two new equivalent orbitals while sp2 hybridization is observed when one s and two p orbitals of the same shell of an atom mix to form three equivalent orbitals).
Graphene vs Graphyne
Graphene and graphyne are both single-atom-thick sheets of carbon atoms. In graphene, individual carbon atoms bond together in a strict hexagonal pattern (see image above). Graphyne bonds are different. Single sheets of graphyne consist of carbon atoms joined together in varying combinations of double and triple bonds.
The different combinations create different structures that all potentially have different properties (Graphyne-n). Because the carbon atoms can bond in subtly different arrangements, there is potentially a large number of types of graphynes with properties potentially superior to graphene for certain applications.
Researchers have theorized a number of differences between graphene and graphyne and the implications for use in commercial applications. These differences include:
Strength: The triple bonds in graphyne are seen to make the material more rigid than graphene; as a result of increased rigidity, graphyne may be less flexible, more brittle, and less mechanically strong overall than graphene.
Porosity: Graphyne has nanopores between atoms that are large enough for molecules the size of water to pass through, while the structure of graphene is very tight and generally impermeable; as a result, graphyne may be more useful for such applications as desalination as the nanopores are large enough for water to pass through, but not salt.
Band Gap: Ongoing research suggests that the band gap of graphyne is mechanically tunable, which facilitates the manufacture of a variety of transistors, including those that depend on a specific on-off ratio; single-layer graphene has no band gap although researchers in the U.S. and France have produced a form of graphene with a record high band gap of half an electron volt (0.5 eV) which may be sufficient to produce useful graphene transistors in the future.
Commercialization Work Ahead
While graphyne has been successfully created, we need to temper our enthusiasm when it comes to investment opportunities and the commercialization potential of newly discovered nanocarbon materials. Zhang and his team of researchers have a great deal of work to do. They are exploring graphyne from multiple dimensions with the goal of determining how graphyne’s electron-conducting and optical properties can be used for industrial applications (e.g., to produce next-generation lithium-ion batteries).
At the same time, the researchers need to discover ways to lower costs and simplify the reaction procedure of graphyne. When these developments occur is anybody’s guess.
Tour’s laser-induced process for making high-quality graphene at scale was discovered a decade after the material was discovered.
As Paradigm investors, we will need to remain patient while the creative human minds in the world discover ways of producing large volumes of graphyne at a relatively low cost. The same goes for borophene, another promising nanomaterial discussed in our monthly report, “Gobsmacked!” by the Nanocosm” published earlier this year in May.
In the meantime, Tour’s laser-induced and flash graphene are already in the process of finding their way into commercial markets through an ecosystem consisting of some sixteen companies and counting. Investment opportunities in the Nanocosm are mounting.
Walter, you are better than so many doctors! You have a heart of gold, what a gift to humanity!! You will have a special place in heaven!! 🙏🏻❤️
Nice work mate, I can see the round table (zoom) meeting has got you thinking about the furin cleavage site.
It was great to hear you speak, keep up the hard work. 🙏🏻
THANK YOU!
Charles Rixey alludes to the ominous advent of the furin cleavage site that he has been studying during the Round Table.
If you have not already watched it, please consider watching the Round Table with inter alia, Walter Chesnut.
https://www.youtube.com/watch?v=LZMEcXt-ECY
Cited supra is a Round Table with stellar participants, including Walter Chesnut, J. C. Couey, Jessica Rose, Spartacus, and Charles Rixey
.The whole Round Table is almost five hours.
Start at ONE MINUTE
Wondrous Walter, the masters' master brilliant puzzler's ever evolving theory is that we are being damaged by SPIKE INJURY ENDOTHELIAL DISEASE Thus, autoimmunity and prion disease are derived from repetitive injuries.
Start at ONE HOUR THIRTY FOUR MINUTES for his two new discoveries relative to endothelial damage.
Analogizing it to Paraquat poisoning, the blood gas barrier in the lungs is being damaged by endothelial damage and oxygen can not be pumped in. NOT PNEUMONIA. The treatment was all wrong.
The heterogeneity of autoimmune disease subsequent to exposure to the spike protein or the virus is due to repeated injury. Damaged tissue induces autoimmune disease. Whether a person will get what autoimmune disease is heterogeneously dependent on which individual's tissue has suffered repeated injuries and auto-antibodies. Similarly, in the manner of TBI - traumatic brain injury - repeated injury is concurrent with prion disease.Skip through the entire Round Table for compelling discussions
.MY COMPLAINT: MORE WALTER! I wanted to hear more, more, more from Walter!!!!I am hoping that Walter will soon be interviewed again by J C Couey. These are wonderful interviews! PLEASE, PLEASE, PLEASE!!
There was a cystic fibrosis expert on the 2015 Menachery/Baric team that designed SARS-CoV-2 with NIH/NIAID/US-AID and Chinese funding.
Among the authors of the paper bioweapons expert Francis A Boyle calls the smoking gun that should be the cornerstone of criminal prosecutions, was Scott Randell of UNC-Chapel Hill cystic fibrosis center. Along with Wayne Marasco, expert on cancer immunology and AIDS at Harvard.
Menachery/Baric paper in Nature Medicine: SARS-like Cluster of Circulating Bat Coronaviruses Pose Threat for Human Emergence.
https://www.nature.com/articles/nm.3985
Authors and contributors identified in the paper were working at the University of North Carolina, Harvard, US Food and Drug Administration (FDA), Wuhan Institute of Virology and Bellinzona Institute of Microbiology in Switzerland:
Vineet D Menachery, Boyd L Yount Jr, Kari Debbink, Lisa E Gralinski, Jessica A Plante, Rachel L Graham, Trevor Scobey, Eric F Donaldson & Ralph S Baric - Department of Epidemiology, University of North Carolina at Chapel Hill
Kari Debbink & Ralph S Baric - Department of Microbiology and Immunology, University of North Carolina at Chapel Hill.
Sudhakar Agnihothram - National Center for Toxicological Research, Food and Drug Administration, US Department of Health and Human Services, Jefferson, Arkansas
Xing-Yi Ge & Zhengli-Li Shi - Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China
Scott H Randell - Department of Cell Biology and Physiology and Cystic Fibrosis Center, Marsico Lung Institute, University of North Carolina at Chapel Hill
Antonio Lanzavecchia - Institute for Research in Biomedicine, Bellinzona Institute of Microbiology, Zurich, Switzerland
Wayne A Marasco - Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston
Financial support from US NIH-NIAID; NIH National Institute of Aging; NIH National Institute of Diabetes and Digestive and Kidney Disease; US-Agency for International Development through EcoHealth Alliance; and China’s National Natural Science Foundation:
National Institute of Allergy & Infectious Disease and the National Institute of Aging of the US National Institutes of Health (NIH) under awards U19AI109761 (R.S.B.), U19AI107810 (R.S.B.), AI085524 (W.A.M.), F32AI102561 (V.D.M.) and K99AG049092 (V.D.M.)
National Natural Science Foundation of China awards 81290341 (Z.-L.S.) and 31470260 (X.-Y.G.), and
USAID-Emerging Pandemic Threats (EPT)-PREDICT funding from EcoHealth Alliance (Z.-L.S.).
Human airway epithelial cultures were supported by the National Institute of Diabetes and Digestive and Kidney Disease of the NIH under award NIH DK065988 (S.H.R.).
M.T. Ferris (Dept. of Genetics, University of North Carolina) reviewed statistical approaches.
C.T. Tseng (Dept. of Microbiology and Immunology, University of Texas Medical Branch) provided Calu-3 cells.
Roots of the program probably lie in sequence of Congressional acts initiated in 1969 to authorize DOD chemical and biological weapons experiments on soldiers, set up the Special Virus Program within the National Cancer Institute at the NIH, and establish global depopulation — executed quietly and with plausible deniability — as a core American-led, globalist geopolitical strategy.
They were looking for a communicable virus that could cause or accelerate cancer and otherwise shorten lives.
HIV was among the first successful deployments.
A friend was diagnosed with Chronic Lung Fibrosis shortly after his jabs.
Sadly, he's the CEO of a healthcare company and fully on board with getting all the jabs he can.
This may be far out sounding but I watched a vid where the physician being interviewed was saying they believed that they had evidence that the inbred families at the top of the food chain on this planet, the elite as it were, have designed this spike protein in such a way that it does not bind to their version of ACE2 and therefore can not harm THEM. Watching King Charles haphazardly cavorting with and touching all the prols mindlessly packed in around Buckingham Palace during Mum's hideous spectacle would make you wonder. All these people now seem unconcerned, if they ever were, about any of this. What do they know that we don't?
Walter - Please have a read
http://teamsforlife.com/ministry-of-energy/
Many coronaviruses present furin cleavage sites. Notably, in the two human coronaviruses in Alphacoronavirus causing common cold, HCoV NL63 has furin cleavage site at spike S2, and this does not have oncogenic properties. However, this furin cleavage site enhances the transmissibility as well as the tropism of the virus to a plethora of cells.
Fascinating hypothesis. Makes sense to this old doc. Appreciate your working on this so hard!
Thanks. Learning new things here every time.
Maybe this is also related to the sticky blood-clots. According to Ryan Cole they contain white bloodcells glued together via intercellular adhesion molecules. Maybe this is the pathway via which this process gets activated.
Fauc1's name may be on the GP120 patent.
https://pubchem.ncbi.nlm.nih.gov/patent/US-7223390-B2
Furin cleavage = HIV-1
(FURIN CLEAVAGE SEQUENCE [site] IS CTCCTCGGCGGGCACGTAG)
WHY ARE DOCTORS & LAWYERS & ALL OTHERS WHO CAN DO SOMETHING ABOUT STOPPING THE SO CALLED VACCINES NOT STOPPING THEM? EVEN WITH ALL THE EVIDENCE STACKING UP, THEY ARR STILL PUSHING THE POISON!
It must be exciting for those who injected the Dog Shit ... and become aware of the fact that it's extremely dangerous ...
You'd wake up every day wondering --- is this the day I get that twinge of pain... that turns out to be Turbo Cancer...
Walter, I'll contribute to this by mentioning what I've been looking into -- the arginine repeats that likely stem from HIV-1 Tat research. Tat / GP120 are contributors to e.g. neuropathology in HIV. Syncytia-building and extracellular matrix disturbance via MMPs etc. can be provoked by the arginine motif, which could culminate in giant clot gobs found in autopsy and/or disturbance of electrical signaling required to keep us alive (sudden death).
https://medquotes.substack.com/p/not-new-arginine-hiv-tat-lab-tool
https://paradigmpressgroup.com/concierge...now there's a hybrid graphene to consider...they are considering the investment angle, but not the human health impacts.
Here's the text:
New Nanocarbon Discoveries…With More to Come
September 21, 2022
By George Gilder, Richard Vigilante & Steve Waite
As wonder material graphene ascends in the Nanocosm through the pioneering research of Professor James Tour at Rice University and the commercialization efforts of spin-off companies like LIGC and Universal Matter, researchers at the University of Colorado in Boulder, led by Chemistry Professor Wei Zhang, recently made a breakthrough in synthesizing another carbon nanomaterial called graphyne. The pioneering development was published earlier this year in the journal, Nature Synthesis.
Graphyne and its family (which includes graphdiyne, a material first synthesized in 2018 and viewed as having promising potential in a range of commercial applications, including gas separation, catalysis, water remediation, humidity sensor, and energy-related fields.) is a carbon allotrope in 2D form with both sp and sp2 hybridization. You may recall from your chemistry classes that hybridization is defined as the concept of mixing two atomic orbitals to give rise to a new type of hybridized orbitals.
The intermixing process typically results in the formation of hybrid orbitals having entirely different energies, shapes, etc. The carbon atom forms four single bonds wherein the valence-shell s orbital mixes with three valence-shell p orbitals. This combination leads to the formation of four equivalent sp3 mixtures. These will have a tetrahedral arrangement around the carbon which is bonded to four different atoms. Sp hybridization is observed when one s and one p orbital in the same main shell of an atom mix to form two new equivalent orbitals while sp2 hybridization is observed when one s and two p orbitals of the same shell of an atom mix to form three equivalent orbitals).
Graphene vs Graphyne
Graphene and graphyne are both single-atom-thick sheets of carbon atoms. In graphene, individual carbon atoms bond together in a strict hexagonal pattern (see image above). Graphyne bonds are different. Single sheets of graphyne consist of carbon atoms joined together in varying combinations of double and triple bonds.
The different combinations create different structures that all potentially have different properties (Graphyne-n). Because the carbon atoms can bond in subtly different arrangements, there is potentially a large number of types of graphynes with properties potentially superior to graphene for certain applications.
Researchers have theorized a number of differences between graphene and graphyne and the implications for use in commercial applications. These differences include:
Strength: The triple bonds in graphyne are seen to make the material more rigid than graphene; as a result of increased rigidity, graphyne may be less flexible, more brittle, and less mechanically strong overall than graphene.
Porosity: Graphyne has nanopores between atoms that are large enough for molecules the size of water to pass through, while the structure of graphene is very tight and generally impermeable; as a result, graphyne may be more useful for such applications as desalination as the nanopores are large enough for water to pass through, but not salt.
Band Gap: Ongoing research suggests that the band gap of graphyne is mechanically tunable, which facilitates the manufacture of a variety of transistors, including those that depend on a specific on-off ratio; single-layer graphene has no band gap although researchers in the U.S. and France have produced a form of graphene with a record high band gap of half an electron volt (0.5 eV) which may be sufficient to produce useful graphene transistors in the future.
Commercialization Work Ahead
While graphyne has been successfully created, we need to temper our enthusiasm when it comes to investment opportunities and the commercialization potential of newly discovered nanocarbon materials. Zhang and his team of researchers have a great deal of work to do. They are exploring graphyne from multiple dimensions with the goal of determining how graphyne’s electron-conducting and optical properties can be used for industrial applications (e.g., to produce next-generation lithium-ion batteries).
At the same time, the researchers need to discover ways to lower costs and simplify the reaction procedure of graphyne. When these developments occur is anybody’s guess.
Tour’s laser-induced process for making high-quality graphene at scale was discovered a decade after the material was discovered.
As Paradigm investors, we will need to remain patient while the creative human minds in the world discover ways of producing large volumes of graphyne at a relatively low cost. The same goes for borophene, another promising nanomaterial discussed in our monthly report, “Gobsmacked!” by the Nanocosm” published earlier this year in May.
In the meantime, Tour’s laser-induced and flash graphene are already in the process of finding their way into commercial markets through an ecosystem consisting of some sixteen companies and counting. Investment opportunities in the Nanocosm are mounting.
Carpe diem!