So, the pathobiology of internal calcification so internal calcification first starts off with atherosclerosis so atherosclerosis occurs before internal calcification and we know that atherosclerosis is an inflammatory process that starts with damage of the endothelium then monocytes enter the artery an…
So, the pathobiology of internal calcification so internal calcification first starts off with atherosclerosis so atherosclerosis occurs before internal calcification and we know that atherosclerosis is an inflammatory process that starts with damage of the endothelium then monocytes enter the artery and differentiate into macrophages which proliferate locally they ingest oxidized lipids and then they slowly start to turn into large foamy macrophages and then they eventually die and which further propagates the inflammatory process in addition the smooth muscle cells start to proliferate and they migrate from the vessel wall in response to cytokines that is secreted by damaged endothelium cells and by the dying cells and they help and these smooth muscle cells are thought to help form the fibrous cap then the calcification starts to occur and internal calcification really resembles endochondral bone formation and although the initiation of the calcification does not require participation by specific cells but the progression of the lesion is thought to be likely driven by chondrocyte-like cells and associated with expression of inflammatory factors like cytokines…
Aletheia. I recognised what you are addressing; but at the same time I recognised that the word "and" is a conjunction (connecting two things together, even when in a long chain of connections--and it has always been that way); and then I recognised that Walter was providing a chain-linkage (and even with some add-on thoughts); but altogether Walter is one of the first PRO's who has ever done that in my 3.5 year personal study (x 8hrs a day, every day while trying to understand things I have none-whatsoever-background in--namely Wuhan air-born distributed Covid-19 and Pfizer/Moderna Jab Covid-19). I was an earth science guy, not a biology guy). Because Walter did it this way, I understood perfectly THE CHAIN, while being unfamiliar with the content of the chain; but I am still very pleased he did it this way--BECAUSE HE UNIFIED THE WHOLE THING (to me that is the main point). When others wrote in "proper English (as it may be called)--I got lost in perfect sentence after sentence, due to being unfamiliar with "the whole". But I did not get lost with Walter's style of presenting this, because I recognised immediately HE WAS LAYING OUT A CHAIN. And for whatever it is worth. I still do not understand auto mechanics related to combustion and the movement of cars, etc. I am a person who gets lost when provided too many details. But I didn't get lost in Walter's presentation because he was presenting A FULL CHAIN. Now at least I got the chain, and just with the connective conjunction word "and". I did not feel like I was among the dumbest people on earth. I felt like I was being given a gift (even though I did not understand it all). So here is another way my weird mind works. When I read the "letter, so to speak" period (.)--my mind stops right there. I want to say, "Oh shit! There is a period. I'm supposed to stop there; and then I never know for sure if the next sentence COULD BE connected to the previous sentence. I can't trust because people like me, we kind of float to one thing and another thing and always wondering if there was something I missed, when ignorant of the subject material. By Walter's use of "and" I knew I missed NOTHING--and now all I have to do is research each step of the chain to understand more. But Aletheia, thanks for bringing up your issue--that too, made me think aplenty.
Is this what he is trying to say? Walter, is this what you are trying to show?
The pathobiology of internal calcification follows this process:
1. An inflammatory process starts with damage of the endothelium
2. Monocytes enter the artery and differentiate into macrophages
3. These proliferate locally
4. They ingest oxidized lipids and then they slowly start to turn into large foamy macrophages
5. Eventually they die, which further propagates the inflammatory process
6. The smooth muscle cells start to proliferate, migrating from the vessel wall in response to cytokines secreted by damaged endothelium cells and by the dying cells
7. These smooth muscle cells help form fibrous cap (cap to what
With respect to #1 above, although the initiation of the calcification does not require participation by specific cells, the progression of the lesion is likely driven by chondrocyte-like cells and associated with expression of inflammatory factors like cytokines.
Something is wrong with this quote:
So, the pathobiology of internal calcification so internal calcification first starts off with atherosclerosis so atherosclerosis occurs before internal calcification and we know that atherosclerosis is an inflammatory process that starts with damage of the endothelium then monocytes enter the artery and differentiate into macrophages which proliferate locally they ingest oxidized lipids and then they slowly start to turn into large foamy macrophages and then they eventually die and which further propagates the inflammatory process in addition the smooth muscle cells start to proliferate and they migrate from the vessel wall in response to cytokines that is secreted by damaged endothelium cells and by the dying cells and they help and these smooth muscle cells are thought to help form the fibrous cap then the calcification starts to occur and internal calcification really resembles endochondral bone formation and although the initiation of the calcification does not require participation by specific cells but the progression of the lesion is thought to be likely driven by chondrocyte-like cells and associated with expression of inflammatory factors like cytokines…
We used to have to diagram sentences when we were kids. I shudder over this one....
😉
Aletheia. I recognised what you are addressing; but at the same time I recognised that the word "and" is a conjunction (connecting two things together, even when in a long chain of connections--and it has always been that way); and then I recognised that Walter was providing a chain-linkage (and even with some add-on thoughts); but altogether Walter is one of the first PRO's who has ever done that in my 3.5 year personal study (x 8hrs a day, every day while trying to understand things I have none-whatsoever-background in--namely Wuhan air-born distributed Covid-19 and Pfizer/Moderna Jab Covid-19). I was an earth science guy, not a biology guy). Because Walter did it this way, I understood perfectly THE CHAIN, while being unfamiliar with the content of the chain; but I am still very pleased he did it this way--BECAUSE HE UNIFIED THE WHOLE THING (to me that is the main point). When others wrote in "proper English (as it may be called)--I got lost in perfect sentence after sentence, due to being unfamiliar with "the whole". But I did not get lost with Walter's style of presenting this, because I recognised immediately HE WAS LAYING OUT A CHAIN. And for whatever it is worth. I still do not understand auto mechanics related to combustion and the movement of cars, etc. I am a person who gets lost when provided too many details. But I didn't get lost in Walter's presentation because he was presenting A FULL CHAIN. Now at least I got the chain, and just with the connective conjunction word "and". I did not feel like I was among the dumbest people on earth. I felt like I was being given a gift (even though I did not understand it all). So here is another way my weird mind works. When I read the "letter, so to speak" period (.)--my mind stops right there. I want to say, "Oh shit! There is a period. I'm supposed to stop there; and then I never know for sure if the next sentence COULD BE connected to the previous sentence. I can't trust because people like me, we kind of float to one thing and another thing and always wondering if there was something I missed, when ignorant of the subject material. By Walter's use of "and" I knew I missed NOTHING--and now all I have to do is research each step of the chain to understand more. But Aletheia, thanks for bringing up your issue--that too, made me think aplenty.
Is this what he is trying to say? Walter, is this what you are trying to show?
The pathobiology of internal calcification follows this process:
1. An inflammatory process starts with damage of the endothelium
2. Monocytes enter the artery and differentiate into macrophages
3. These proliferate locally
4. They ingest oxidized lipids and then they slowly start to turn into large foamy macrophages
5. Eventually they die, which further propagates the inflammatory process
6. The smooth muscle cells start to proliferate, migrating from the vessel wall in response to cytokines secreted by damaged endothelium cells and by the dying cells
7. These smooth muscle cells help form fibrous cap (cap to what
8. Internal calcification begins (Internal calcification really resembles endochondral bone formation)
With respect to #1 above, although the initiation of the calcification does not require participation by specific cells, the progression of the lesion is likely driven by chondrocyte-like cells and associated with expression of inflammatory factors like cytokines.
wouldn't k2 help with the calcification?