The Spike Protein's agonist relationship with nAChR receptors
Solutions: Nicotine lozenges, and a few other possibilities are in this post:
Catecholamine-mediated stress myocarditis, spike S1 and alpha 7 nAChRs. https://denutrients.substack.com/p/catecholamine-mediated-stress-myocarditis
The alpha 7 nAChRs are also involved in implantation of the fetus in the uterus, and myocarditis, and sensory perception.
And Pomegranate peel to prevent the fusion cleavage site from opening - no free S1, no alpha 7 nAChR blockage. https://denutrients.substack.com/p/ways-pomegranate-protects-against
This post is also related: "Peace is recognizing that we instinctually fear and worry. Let it go." "Trauma seems to lead to disruption of the Autonomic Nervous System (ANS). The person never feels safe, which affects mood and even facial affect. The lack of emotional expressiveness of autism may involve changes in the ANS...." https://www.peace-is-happy.org/post/peace-is-recognizing-that-we-instinctually-fear-and-worry-let-it-go - Mental adjustment may be critically important - are we listening to placebos or nocebos? We can make ourselves sick with worry. Covid19 symptoms are also symptoms of chronic fear/stress as you pointed out a long time ago while still on Twitter, Walter.
OK I’m trying to figure this out. ￼Catecholamines are hormones produced in the brain, nerve tissues, and adrenal glands in response to stress (fight/flight). If this system surges at the same time the sympathetic system kicks into overdrive then the body could be overwhelmed with with an extreme/unmanageable fight/flight response. Is that what you mean? Would this explain SAD?
walter - if i may, you might find interesting the below podcast, and this post by brian mowrey which gave me some more background as a layman to understand what is going. it is a amazing how the cell functions, the more you know about the body the more one believes in God. it all connects.
Brilliant. The number 2 comorbidity for severe COVID (hospitalization and death) behind #1 (morbid obesity - Vit D deficient) is anxiety. The 24/7/365 fear porn has been a successful part of the program to cull the herd, IMO.
So the qualities that Thyme and Oregano essentialise from nature are also the qualities that intercept this uncontrolled kickon and put a space for a little courage, balance and moderation in a human way?
Vaping/nicotine patches/nicotine gum/tobacco use ameliorates this effect? https://pubmed.ncbi.nlm.nih.gov/12428730/
On the flip side, the paper states, "It activates the α7 nAChR, in line with our previous molecular dynamics simulations showing favorable binding of this accessible region of the S protein to the nAChR agonist binding pocket. However, activation requires the presence of positive allosteric modulators that enhance channel opening probability, indicating very "low activation efficacy". The S fragment exerts an additional inhibition, which may be the predominant effect on α7 responses". The last part, "predominant effect", this is what I have been looking at for a long time. The bungarotoxin effect, and its issue with "cholinergic activation pathway", CAP. the agonist vs. antagonist effects, which one prevails? IMO , its an antagonist issue, and as well as an antibody effect from the immune system altering the ACh receptors and other ligands, like SLURP1, . Bradykinin potentiating proteins, hmm, take a look at FAR. and PRRA amino acid sequencing and molecular symmetry and mimicry. Rabies? Hmmm yes I noted that commonality as well, look at vaccine development , clue into gp120 . Just something to ponder! I have stoped most of my research because, as you know, the academia as well as researchers are so quiet. Anything us researchers, the ones un paid, find to be alarming, just fall on deaf ears, and gain no worth until peer reviewed papers come out. I dont mind, If you ever want nicotinic receptor research I have done, just let me know and I will flood your pentagonal gate!! Peace.
So would this be helpful in stopping it?
heaven forbid we should come back in another life as a lab rat. brrrhh. oh, wait.
I chew a 2mg piece of nicotine gum each time before I leave my home and venture out into the world. I learned of this from Dr. Bryan Ardis a few months back.
Walter, I have a question, although I may be barking up the wrong tree!
You mention ‘Stimulation of brain nicotinic acetylcholine receptors activates adrenomedullary outflow ‘.
I’ve been T1D for 25 yrs & have noticed ‘unexplained’ elevations in BG levels on a more consistent basis in past 18m. It could be insulin resistance but my hunch is that this isn’t the main cause as the levels don’t seem to relate to carb consumption & I’m reasonably slim/fit/otherwise healthy. I think it’s related to endogenous glucose production/glycolysis. May be unrelated to SC2 but your mention of adrenomedullary outflow got me thinking as this could make sense as a possible cause of non carb consumption related elevations in BG levels?
Your making no sense anymore Walter.
Your just talking and writing to yourself.
If your brain cannot translate your hypothesis to English and the common man, your better off holding a seminar withi like minded scientific brothers.