This post is also related: "Peace is recognizing that we instinctually fear and worry. Let it go." "Trauma seems to lead to disruption of the Autonomic Nervous System (ANS). The person never feels safe, which affects mood and even facial affect. The lack of emotional expressiveness of autism may involve changes in the ANS...." https://www.peace-is-happy.org/post/peace-is-recognizing-that-we-instinctually-fear-and-worry-let-it-go - Mental adjustment may be critically important - are we listening to placebos or nocebos? We can make ourselves sick with worry. Covid19 symptoms are also symptoms of chronic fear/stress as you pointed out a long time ago while still on Twitter, Walter.
It would not likely protect the actual receptor from S1 subunit entry. What it would do in that case is unknown from info on its actions with acetylcholine - curcumin would help pain in moderate choline deficiency is said in that paper.
That is a really helpful link, thanks for sharing it. It is going in my pomegranate paper. What it is also suggesting is that nociceptive pain is mitigated by adequate acetylcholine function (or nicotine or galantamine, etc), and that chronic pain would be worsened by a choline deficiency. ... And that curcumin also would help nociceptive pain by promoting modulation of the alpha 7 nAChRs. I feel like I just got a Christmas present - thanks guest.
Maybe it would help block spike effects but I am not sure if it would restore function. Allosteric modulators assist/stabilize or modify an agonist's action at a receptor, but wouldn't be an agonist that fits in the receptor by itself. It might help though, I am not sure.
Curcumin is beneficial as a Vitamin D Receptor agonist that allows some function but not as much of the calcium flow - so safer than D supplements for someone with excess calcium/heart disease or inflammation issues.
OK I’m trying to figure this out. Catecholamines are hormones produced in the brain, nerve tissues, and adrenal glands in response to stress (fight/flight). If this system surges at the same time the sympathetic system kicks into overdrive then the body could be overwhelmed with with an extreme/unmanageable fight/flight response. Is that what you mean? Would this explain SAD?
walter - if i may, you might find interesting the below podcast, and this post by brian mowrey which gave me some more background as a layman to understand what is going. it is a amazing how the cell functions, the more you know about the body the more one believes in God. it all connects.
Brilliant. The number 2 comorbidity for severe COVID (hospitalization and death) behind #1 (morbid obesity - Vit D deficient) is anxiety. The 24/7/365 fear porn has been a successful part of the program to cull the herd, IMO.
So the qualities that Thyme and Oregano essentialise from nature are also the qualities that intercept this uncontrolled kickon and put a space for a little courage, balance and moderation in a human way?
On the flip side, the paper states, "It activates the α7 nAChR, in line with our previous molecular dynamics simulations showing favorable binding of this accessible region of the S protein to the nAChR agonist binding pocket. However, activation requires the presence of positive allosteric modulators that enhance channel opening probability, indicating very "low activation efficacy". The S fragment exerts an additional inhibition, which may be the predominant effect on α7 responses". The last part, "predominant effect", this is what I have been looking at for a long time. The bungarotoxin effect, and its issue with "cholinergic activation pathway", CAP. the agonist vs. antagonist effects, which one prevails? IMO , its an antagonist issue, and as well as an antibody effect from the immune system altering the ACh receptors and other ligands, like SLURP1, . Bradykinin potentiating proteins, hmm, take a look at FAR. and PRRA amino acid sequencing and molecular symmetry and mimicry. Rabies? Hmmm yes I noted that commonality as well, look at vaccine development , clue into gp120 . Just something to ponder! I have stoped most of my research because, as you know, the academia as well as researchers are so quiet. Anything us researchers, the ones un paid, find to be alarming, just fall on deaf ears, and gain no worth until peer reviewed papers come out. I dont mind, If you ever want nicotinic receptor research I have done, just let me know and I will flood your pentagonal gate!! Peace.
I have about 40 articles, prints, on nicotinic receptors, here is one thats interesting since you and Kevin brought this up, "Sequence homology between HIV gp120, rabies virus glycoprotein, and snake venom neurotoxins. Is the nicotinic acetylcholine receptor an HIV receptor?" https://pubmed.ncbi.nlm.nih.gov/2241576/
I chew a 2mg piece of nicotine gum each time before I leave my home and venture out into the world. I learned of this from Dr. Bryan Ardis a few months back.
Walter, I have a question, although I may be barking up the wrong tree!
You mention ‘Stimulation of brain nicotinic acetylcholine receptors activates adrenomedullary outflow ‘.
I’ve been T1D for 25 yrs & have noticed ‘unexplained’ elevations in BG levels on a more consistent basis in past 18m. It could be insulin resistance but my hunch is that this isn’t the main cause as the levels don’t seem to relate to carb consumption & I’m reasonably slim/fit/otherwise healthy. I think it’s related to endogenous glucose production/glycolysis. May be unrelated to SC2 but your mention of adrenomedullary outflow got me thinking as this could make sense as a possible cause of non carb consumption related elevations in BG levels?
Yes, and I do apologize to James for being so terse; I'm a scientist and have devoured the material here...Walter, everything you have written from the beginning has been erudite and keen and in some cases literally mind-blowing, but, it is not light reading. ;-}
Things ‘making sense’ is subjective. I have no scientific training at all. The past few years has piqued a previously untapped interest in biology, immunology etc. I’m experiencing a very steep learning curve, lot’s of Walter’s stacks are initially 90% gobbledegook to me! However it’s an interesting way of learning, quite different to the start with the basics and add building blocks approach to my schooling. I’m delving into cutting edge hypotheses and complicates science and reverse engineering my knowledge. It’s been intellectually stimulating and simultaneously a bit of a head fuck, constantly being thrown into tangential pathways of education (and conspiracy!!)
Please keep up your wonderful work Walter. I loved your recent vid with JC. The joy on your face when you and he had some lightbulb moments is a very neat expression of why we are in this fight for humanity.
Solutions: Nicotine lozenges, and a few other possibilities are in this post:
Catecholamine-mediated stress myocarditis, spike S1 and alpha 7 nAChRs. https://denutrients.substack.com/p/catecholamine-mediated-stress-myocarditis
The alpha 7 nAChRs are also involved in implantation of the fetus in the uterus, and myocarditis, and sensory perception.
And Pomegranate peel to prevent the fusion cleavage site from opening - no free S1, no alpha 7 nAChR blockage. https://denutrients.substack.com/p/ways-pomegranate-protects-against
This post is also related: "Peace is recognizing that we instinctually fear and worry. Let it go." "Trauma seems to lead to disruption of the Autonomic Nervous System (ANS). The person never feels safe, which affects mood and even facial affect. The lack of emotional expressiveness of autism may involve changes in the ANS...." https://www.peace-is-happy.org/post/peace-is-recognizing-that-we-instinctually-fear-and-worry-let-it-go - Mental adjustment may be critically important - are we listening to placebos or nocebos? We can make ourselves sick with worry. Covid19 symptoms are also symptoms of chronic fear/stress as you pointed out a long time ago while still on Twitter, Walter.
Would curcumin be an alternative option?
"Curcumin Acts as a Positive Allosteric Modulator of α7-Nicotinic Acetylcholine Receptors and Reverses Nociception in Mouse Models of Inflammatory Pain" - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7947331/
Answer is in the paper - no "Curcumin did not alter specific binding of [125I]α-bungarotoxin." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7947331/
It would not likely protect the actual receptor from S1 subunit entry. What it would do in that case is unknown from info on its actions with acetylcholine - curcumin would help pain in moderate choline deficiency is said in that paper.
[125]alpha-bungarotoxin is similar to conotoxins https://jpet.aspetjournals.org/content/325/3/910
That is a really helpful link, thanks for sharing it. It is going in my pomegranate paper. What it is also suggesting is that nociceptive pain is mitigated by adequate acetylcholine function (or nicotine or galantamine, etc), and that chronic pain would be worsened by a choline deficiency. ... And that curcumin also would help nociceptive pain by promoting modulation of the alpha 7 nAChRs. I feel like I just got a Christmas present - thanks guest.
Maybe it would help block spike effects but I am not sure if it would restore function. Allosteric modulators assist/stabilize or modify an agonist's action at a receptor, but wouldn't be an agonist that fits in the receptor by itself. It might help though, I am not sure.
Curcumin is beneficial as a Vitamin D Receptor agonist that allows some function but not as much of the calcium flow - so safer than D supplements for someone with excess calcium/heart disease or inflammation issues.
So smoking kills but also could potentially help in this shitshow?
I heard cannabis could help but I'm reluctant to open that door to tobacco as wel... lmao
OK I’m trying to figure this out. Catecholamines are hormones produced in the brain, nerve tissues, and adrenal glands in response to stress (fight/flight). If this system surges at the same time the sympathetic system kicks into overdrive then the body could be overwhelmed with with an extreme/unmanageable fight/flight response. Is that what you mean? Would this explain SAD?
Basically, Yes!
I just now noticed you posted additional information. I will read that next
walter - if i may, you might find interesting the below podcast, and this post by brian mowrey which gave me some more background as a layman to understand what is going. it is a amazing how the cell functions, the more you know about the body the more one believes in God. it all connects.
Keep going!!
https://unglossed.substack.com/p/the-molecular-lung
https://mediaarchives.gsradio.net/rense/special/rense_102122_hr2.mp3
Brilliant. The number 2 comorbidity for severe COVID (hospitalization and death) behind #1 (morbid obesity - Vit D deficient) is anxiety. The 24/7/365 fear porn has been a successful part of the program to cull the herd, IMO.
So the qualities that Thyme and Oregano essentialise from nature are also the qualities that intercept this uncontrolled kickon and put a space for a little courage, balance and moderation in a human way?
Vaping/nicotine patches/nicotine gum/tobacco use ameliorates this effect? https://pubmed.ncbi.nlm.nih.gov/12428730/
Nicotinic acid is basicly B3
On the flip side, the paper states, "It activates the α7 nAChR, in line with our previous molecular dynamics simulations showing favorable binding of this accessible region of the S protein to the nAChR agonist binding pocket. However, activation requires the presence of positive allosteric modulators that enhance channel opening probability, indicating very "low activation efficacy". The S fragment exerts an additional inhibition, which may be the predominant effect on α7 responses". The last part, "predominant effect", this is what I have been looking at for a long time. The bungarotoxin effect, and its issue with "cholinergic activation pathway", CAP. the agonist vs. antagonist effects, which one prevails? IMO , its an antagonist issue, and as well as an antibody effect from the immune system altering the ACh receptors and other ligands, like SLURP1, . Bradykinin potentiating proteins, hmm, take a look at FAR. and PRRA amino acid sequencing and molecular symmetry and mimicry. Rabies? Hmmm yes I noted that commonality as well, look at vaccine development , clue into gp120 . Just something to ponder! I have stoped most of my research because, as you know, the academia as well as researchers are so quiet. Anything us researchers, the ones un paid, find to be alarming, just fall on deaf ears, and gain no worth until peer reviewed papers come out. I dont mind, If you ever want nicotinic receptor research I have done, just let me know and I will flood your pentagonal gate!! Peace.
I have about 40 articles, prints, on nicotinic receptors, here is one thats interesting since you and Kevin brought this up, "Sequence homology between HIV gp120, rabies virus glycoprotein, and snake venom neurotoxins. Is the nicotinic acetylcholine receptor an HIV receptor?" https://pubmed.ncbi.nlm.nih.gov/2241576/
Have fun!
So would this be helpful in stopping it?
https://en.wikipedia.org/wiki/Hexamethonium
heaven forbid we should come back in another life as a lab rat. brrrhh. oh, wait.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135790/
I chew a 2mg piece of nicotine gum each time before I leave my home and venture out into the world. I learned of this from Dr. Bryan Ardis a few months back.
Walter, I have a question, although I may be barking up the wrong tree!
You mention ‘Stimulation of brain nicotinic acetylcholine receptors activates adrenomedullary outflow ‘.
I’ve been T1D for 25 yrs & have noticed ‘unexplained’ elevations in BG levels on a more consistent basis in past 18m. It could be insulin resistance but my hunch is that this isn’t the main cause as the levels don’t seem to relate to carb consumption & I’m reasonably slim/fit/otherwise healthy. I think it’s related to endogenous glucose production/glycolysis. May be unrelated to SC2 but your mention of adrenomedullary outflow got me thinking as this could make sense as a possible cause of non carb consumption related elevations in BG levels?
Your making no sense anymore Walter.
Your just talking and writing to yourself.
If your brain cannot translate your hypothesis to English and the common man, your better off holding a seminar withi like minded scientific brothers.
He's making sense...perhaps you should stop reading what you can't understand...
Thank you, Sandy. Apologies, James. I am working through a major breakthrough. Perhaps my next post will be easier to understand.
Yes, and I do apologize to James for being so terse; I'm a scientist and have devoured the material here...Walter, everything you have written from the beginning has been erudite and keen and in some cases literally mind-blowing, but, it is not light reading. ;-}
Thank you, Sandy. And when I discovered this tonight, it actually blew my mind.
https://wmcresearch.substack.com/p/synthesis-of-my-previous-two-posts
We're all on the same team Sandy.
I am still rooting for you Walter.
if you know whats good for you :)
Things ‘making sense’ is subjective. I have no scientific training at all. The past few years has piqued a previously untapped interest in biology, immunology etc. I’m experiencing a very steep learning curve, lot’s of Walter’s stacks are initially 90% gobbledegook to me! However it’s an interesting way of learning, quite different to the start with the basics and add building blocks approach to my schooling. I’m delving into cutting edge hypotheses and complicates science and reverse engineering my knowledge. It’s been intellectually stimulating and simultaneously a bit of a head fuck, constantly being thrown into tangential pathways of education (and conspiracy!!)
Please keep up your wonderful work Walter. I loved your recent vid with JC. The joy on your face when you and he had some lightbulb moments is a very neat expression of why we are in this fight for humanity.
We assume of others what we know of ourselves.
Walter can share his work here and in a seminar.