The Catecolamine Surge Induced by the Spike Protein
The Spike Protein's agonist relationship with nAChR receptors
The deleterious effects of the Spike Protein can be summed up by Sympathetic Overdrive and Catecolamine Surges. My most recent post details how the Spike Protein induces chronic Sympathetic Overdrive, which I believe is the cause of Long COVID.
I believe I have now determined how the Spike Protein is inducing the Catecolamine Surge, indepently of cardiac manifestations, such as Myocarditis.
The Spike Protein is a nAChR agonist.
The S fragment exerts a dual effect, acting as a low-efficacy agonist and a non-competitive inhibitor. It activates the α7 nAChR, in line with our previous molecular dynamics simulations showing favorable binding of this accessible region of the S protein to the nAChR agonist binding pocket.
A Functional Interaction Between the SARS-CoV-2 Spike Protein and the Human α7 Nicotinic Receptor
https://assets.researchsquare.com/files/rs-938911/v2_covered.pdf?c=1642796702
This very relationship is what, I believe, is inducing the Catecolamine Surges which, in tandem with its activation of Sympathetic Overdrive, is causing the recent rise in Sudden Cardiac Deaths.
Stimulation of brain nAChRs can induce elevation of plasma catecholamines through brain iNOS‐derived NO‐mediated protein S‐nitrosylation in rats.
Stimulation of brain nicotinic acetylcholine receptors activates adrenomedullary outflow via brain inducible NO synthase‐mediated S‐nitrosylation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135790/
The Catecolamine Surge Induced by the Spike Protein
Solutions: Nicotine lozenges, and a few other possibilities are in this post:
Catecholamine-mediated stress myocarditis, spike S1 and alpha 7 nAChRs. https://denutrients.substack.com/p/catecholamine-mediated-stress-myocarditis
The alpha 7 nAChRs are also involved in implantation of the fetus in the uterus, and myocarditis, and sensory perception.
And Pomegranate peel to prevent the fusion cleavage site from opening - no free S1, no alpha 7 nAChR blockage. https://denutrients.substack.com/p/ways-pomegranate-protects-against
This post is also related: "Peace is recognizing that we instinctually fear and worry. Let it go." "Trauma seems to lead to disruption of the Autonomic Nervous System (ANS). The person never feels safe, which affects mood and even facial affect. The lack of emotional expressiveness of autism may involve changes in the ANS...." https://www.peace-is-happy.org/post/peace-is-recognizing-that-we-instinctually-fear-and-worry-let-it-go - Mental adjustment may be critically important - are we listening to placebos or nocebos? We can make ourselves sick with worry. Covid19 symptoms are also symptoms of chronic fear/stress as you pointed out a long time ago while still on Twitter, Walter.
OK I’m trying to figure this out. Catecholamines are hormones produced in the brain, nerve tissues, and adrenal glands in response to stress (fight/flight). If this system surges at the same time the sympathetic system kicks into overdrive then the body could be overwhelmed with with an extreme/unmanageable fight/flight response. Is that what you mean? Would this explain SAD?