Thank you, dear Walter! I got--and recovered from--longhaul covid (PASC) which I came down with in early 2020 and managed to clear by mid-2021. I attribute much of my success to being intuitively guided to start taking daily supplements of natural anti-amyloids. I felt huge improvement when I started taking Quercetin, and I also began taking Curcumin, Green Tea Extract, and Resveratrol. I chose to not add any more spike proteins to my body once I experienced hundreds of debilitating symptoms of longhaul covid--sometimes facing family, friends and neighbors demanding I 'protect myself' with the jab. I chose to not go that route, stating I'd already had far more than enough spike protein, thank you very much.
Here's an intriguing research article dating back pre-pandemic, sharing some natural anti-amyloid substances that can be good nutraceuticals we can include in our healthy diets (such as: Curcumin, Green Tea Extract, Quercetin, Resveratrol)
The question I have been trying to get a clear answer to is whether conditions caused by amyloid formation can be REVERSED or whether amyloids need to be prevented and once they have formed it is too late. You post seems to imply that it can be treated/reversed. If this is so, please share more information on this. Thank you.
Yes! My recovery from longhaul covid gives me hope that we can help all of humanity turn this around. I am deeply concerned that Walter is correct, and everyone is at risk from each subsequent exposure to spike proteins. I've so far been fortunate to only have had the one exposure (that I know of) to the spike protein, and that was my original infection in January 2020. It felt like a bad flu, but the aftermath for me with longhaul covid was truly horrific. I was not hospitalized, and read medical research papers until I began finding my way out of the mess, utilizing natural supplements including those I mentioned above: Quercetin, Resveratrol, Curcumin, and Green Tea. Thanks to Walter's research, I'm now seeing the amyloid connection, and the reason these particular supplements were super effective in my recovery becomes clear. So yes, thanks to my experience I see we really can reverse this. The research article I found and posted above seems to indicate earlier treatment with anti-amyloids is recommended. My recovery journal notes show that I (finally)! began taking all four of these (Turmeric, Resveratrol, Green Tea, Quercetin) starting in month 10 of my longhaul covid experience. Apparently that was still catching it early enough to turn it around--so this can give us all hope.
I generally take low doses, and mostly go by ingredients listed and reviews when selecting which ones to take. I just take supplements once a day, with a meal.
Do you happen to have links to any papers about the mechanisms by which these supplements aid in the healing process from PASC (long COVID)? You said the reason they are effective became clear but it isn't clear to me because I don't know enough yet. Thanks.
I'm not yet aware of any such research papers specifically addressing PASC. I had to work out what could help me recover from PASC, and I was paying attention to medical researchers who had longhaul covid the most. It was thanks to listening to them when they came on YouTube channels such as Run-DMC with Gez Medinger, or on Dr. Mobeen's channel. I paid attention to several different sets or suites of factors, including such things as Mast Cell Activation Syndrome (MCAS); athletic history (Niacin issues); and viral debris theory. I kept a detailed journal of what I learned along the way and what worked for me. I needed to get myself healthy, and learned from my symptoms that they were rapidly aging me--just like Walter Chesnut describes. That was my cue to seek out anti-oxidant supplements from the "longevity aisle," and that's how I found the anti-amyloid supplements and got to experience first hand how they immediately stopped some of my symptoms at that time, such as the brain fog, arthritis, and tremors.
“However, I maintain the COVID-19 and Long COVID are both hyper-accelerated Amyloid Deposition Diseases. I believe the reason Minocycline may be a successful therapeutic for COVID-19 resides in the fact that the drug is also a potent ANTI-AMYLOID!”
There is a whole chronic minocycline-consuming community out there with Lyme, RA and SM, with all their fora, Herxheimer reactions discussed, etc. Some people use it for very long times without much of adverse events. All these are autoimmune diseases (and most of them might originate from molecular mimicries caused by improved microbes at Plum Island if you know what I mean). I am originally researching methods to decrease/reverse AD and microglial activation but I have found no effective chemical method yet. Minocycline in my opinion, will decrease microglial inflammation, but currently we have nothing to reverse amyloid deposition or prion accumulation for that matter. Minocycline has been long proposed as an effective macrophage `tamer` and it does have antiviral effects, too. (As well as restoring mitochondrial function which is key in covid.)
. 2014 Jan 3;6(1):2. doi: 10.1186/alzrt232. eCollection 2014.
Photobiomodulation with near infrared light mitigates Alzheimer's disease-related pathology in cerebral cortex - evidence from two transgenic mouse models
Sivaraman Purushothuman 1, Daniel M Johnstone 1, Charith Nandasena 1, John Mitrofanis 2, Jonathan Stone 1
Introduction: Previous work has demonstrated the efficacy of irradiating tissue with red to infrared light in mitigating cerebral pathology and degeneration in animal models of stroke, traumatic brain injury, parkinsonism and Alzheimer's disease (AD). Using mouse models, we explored the neuroprotective effect of near infrared light (NIr) treatment, delivered at an age when substantial pathology is already present in the cerebral cortex.
Methods: We studied two mouse models with AD-related pathologies: the K369I tau transgenic model (K3), engineered to develop neurofibrillary tangles, and the APPswe/PSEN1dE9 transgenic model (APP/PS1), engineered to develop amyloid plaques. Mice were treated with NIr 20 times over a four-week period and histochemistry was used to quantify AD-related pathological hallmarks and other markers of cell damage in the neocortex and hippocampus.
Results: In the K3 mice, NIr treatment was associated with a reduction in hyperphosphorylated tau, neurofibrillary tangles and oxidative stress markers (4-hydroxynonenal and 8-hydroxy-2'-deoxyguanosine) to near wildtype levels in the neocortex and hippocampus, and with a restoration of expression of the mitochondrial marker cytochrome c oxidase in surviving neurons. In the APP/PS1 mice, NIr treatment was associated with a reduction in the size and number of amyloid-β plaques in the neocortex and hippocampus.
Conclusions: Our results, in two transgenic mouse models, suggest that NIr may have potential as an effective, minimally-invasive intervention for mitigating, and even reversing, progressive cerebral degenerations.
Walter do you think natural substances like Serrapeptase or Nattokinase would be helpful? I believe I've read that they both break down fibrin (or something to that effect).
Only 40% of the Japanese consuming natto enjoyed it. Must tast terrible :-) Nattokinase supplement sounds better. Could you please elaborate on what effect you see from bromelain and nattokinase? Must be significant since you recommend them. Other things you recommend that you see have positive effects?
The effects of a healthy and reinforced microbiome are paramount. SCV/2, as in FIP, stays in the gut. A healthy bacterial flora helps elimination of that, and trains the immune system properly. Natto is bad taste
On the other hand, these proteolytic enzymes might cleave i) fibrin ii) the spike itself. But in all cases, the changes in eating habits must turn towards fermented food (sauerkraut, yogurt etc.) and high and accessible flavonoid diet.
Neuroprotective Effects of Quercetin in Alzheimer’s Disease
"... In addition to its antioxidant properties, it inhibits the fibril formation of amyloid-β proteins, counteracting cell lyses and inflammatory cascade pathways"
Quercetin binding accelerates prion fibrillation into proteinase sensitive and loosely structured amyloids
"...Prion diseases are carried out when accumulated PrPSc cannot be degraded efficiently. In human brain, PrPSc largely accumulates in astrocytes and microglia. The accumulated PrPSc can be cleared by phagocytosis. After PrPSc infection, microglia would enhance activity of phagocytosis by astrocyte-derived milk fat globule-epidermal growth factor 8 to remove PrPSc. When PrPSc clearance by microglia is inefficient, microglia would be activated by accumulated PrPSc and would consequently produce proinflammatory mediators resulting in neuron damage. As we found that quercetin binds to PrP and enhances the proteinase sensitivity of PrP fibrils, quercetin can potentially increase the clearance of PrPSc to prevent microglia activation and following neuroinflammation."
Quercetin Shows the Pharmacological Activity to Simultaneously Downregulate the Inflammatory and Fibrotic Responses to Tissue Injury in Association with its Ability to Target Multi-Kinases
Loving your constant research, dear Walter.
Keep it up!
Thank you, dear Walter! I got--and recovered from--longhaul covid (PASC) which I came down with in early 2020 and managed to clear by mid-2021. I attribute much of my success to being intuitively guided to start taking daily supplements of natural anti-amyloids. I felt huge improvement when I started taking Quercetin, and I also began taking Curcumin, Green Tea Extract, and Resveratrol. I chose to not add any more spike proteins to my body once I experienced hundreds of debilitating symptoms of longhaul covid--sometimes facing family, friends and neighbors demanding I 'protect myself' with the jab. I chose to not go that route, stating I'd already had far more than enough spike protein, thank you very much.
Here's an intriguing research article dating back pre-pandemic, sharing some natural anti-amyloid substances that can be good nutraceuticals we can include in our healthy diets (such as: Curcumin, Green Tea Extract, Quercetin, Resveratrol)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841551/
The question I have been trying to get a clear answer to is whether conditions caused by amyloid formation can be REVERSED or whether amyloids need to be prevented and once they have formed it is too late. You post seems to imply that it can be treated/reversed. If this is so, please share more information on this. Thank you.
Yes! My recovery from longhaul covid gives me hope that we can help all of humanity turn this around. I am deeply concerned that Walter is correct, and everyone is at risk from each subsequent exposure to spike proteins. I've so far been fortunate to only have had the one exposure (that I know of) to the spike protein, and that was my original infection in January 2020. It felt like a bad flu, but the aftermath for me with longhaul covid was truly horrific. I was not hospitalized, and read medical research papers until I began finding my way out of the mess, utilizing natural supplements including those I mentioned above: Quercetin, Resveratrol, Curcumin, and Green Tea. Thanks to Walter's research, I'm now seeing the amyloid connection, and the reason these particular supplements were super effective in my recovery becomes clear. So yes, thanks to my experience I see we really can reverse this. The research article I found and posted above seems to indicate earlier treatment with anti-amyloids is recommended. My recovery journal notes show that I (finally)! began taking all four of these (Turmeric, Resveratrol, Green Tea, Quercetin) starting in month 10 of my longhaul covid experience. Apparently that was still catching it early enough to turn it around--so this can give us all hope.
What amounts of each do you take? Do you take some AM and some PM? Are there any brands or concentrations etc you recommend? Thank you!
I generally take low doses, and mostly go by ingredients listed and reviews when selecting which ones to take. I just take supplements once a day, with a meal.
Thank you!!
Thank for for sharing HOPE.
Do you happen to have links to any papers about the mechanisms by which these supplements aid in the healing process from PASC (long COVID)? You said the reason they are effective became clear but it isn't clear to me because I don't know enough yet. Thanks.
I'm not yet aware of any such research papers specifically addressing PASC. I had to work out what could help me recover from PASC, and I was paying attention to medical researchers who had longhaul covid the most. It was thanks to listening to them when they came on YouTube channels such as Run-DMC with Gez Medinger, or on Dr. Mobeen's channel. I paid attention to several different sets or suites of factors, including such things as Mast Cell Activation Syndrome (MCAS); athletic history (Niacin issues); and viral debris theory. I kept a detailed journal of what I learned along the way and what worked for me. I needed to get myself healthy, and learned from my symptoms that they were rapidly aging me--just like Walter Chesnut describes. That was my cue to seek out anti-oxidant supplements from the "longevity aisle," and that's how I found the anti-amyloid supplements and got to experience first hand how they immediately stopped some of my symptoms at that time, such as the brain fog, arthritis, and tremors.
farnesol. Funny how this loops back around to people taking quercetin and vitamin K (with D and zinc) for covid, eh?
Thanks for this article share!
“However, I maintain the COVID-19 and Long COVID are both hyper-accelerated Amyloid Deposition Diseases. I believe the reason Minocycline may be a successful therapeutic for COVID-19 resides in the fact that the drug is also a potent ANTI-AMYLOID!”
This should be front page news.
Very interesting
Thank you. I agree. We need studies to see if this prevents the activation of the Spike's fibril forming properties.
There is a whole chronic minocycline-consuming community out there with Lyme, RA and SM, with all their fora, Herxheimer reactions discussed, etc. Some people use it for very long times without much of adverse events. All these are autoimmune diseases (and most of them might originate from molecular mimicries caused by improved microbes at Plum Island if you know what I mean). I am originally researching methods to decrease/reverse AD and microglial activation but I have found no effective chemical method yet. Minocycline in my opinion, will decrease microglial inflammation, but currently we have nothing to reverse amyloid deposition or prion accumulation for that matter. Minocycline has been long proposed as an effective macrophage `tamer` and it does have antiviral effects, too. (As well as restoring mitochondrial function which is key in covid.)
What do you think of low dose naltrexone? Thank you.
The tetracycline family comes through again. Miracle workers. Thank you, Walter.
Good to see the indian rescue packs contained doxycycline. Thanks for the great work Walter .
I wondered why they did. Hm. How did they know to include it? (not being conspiratorial, wondering what common sense re: mechanisms they used)
Thank you for your brilliant research!
How about photobiomodulation?
Alzheimers Res Ther
. 2014 Jan 3;6(1):2. doi: 10.1186/alzrt232. eCollection 2014.
Photobiomodulation with near infrared light mitigates Alzheimer's disease-related pathology in cerebral cortex - evidence from two transgenic mouse models
Sivaraman Purushothuman 1, Daniel M Johnstone 1, Charith Nandasena 1, John Mitrofanis 2, Jonathan Stone 1
Affiliations expand
PMID: 24387311 PMCID: PMC3978916 DOI: 10.1186/alzrt232
Free PMC article
Abstract
Introduction: Previous work has demonstrated the efficacy of irradiating tissue with red to infrared light in mitigating cerebral pathology and degeneration in animal models of stroke, traumatic brain injury, parkinsonism and Alzheimer's disease (AD). Using mouse models, we explored the neuroprotective effect of near infrared light (NIr) treatment, delivered at an age when substantial pathology is already present in the cerebral cortex.
Methods: We studied two mouse models with AD-related pathologies: the K369I tau transgenic model (K3), engineered to develop neurofibrillary tangles, and the APPswe/PSEN1dE9 transgenic model (APP/PS1), engineered to develop amyloid plaques. Mice were treated with NIr 20 times over a four-week period and histochemistry was used to quantify AD-related pathological hallmarks and other markers of cell damage in the neocortex and hippocampus.
Results: In the K3 mice, NIr treatment was associated with a reduction in hyperphosphorylated tau, neurofibrillary tangles and oxidative stress markers (4-hydroxynonenal and 8-hydroxy-2'-deoxyguanosine) to near wildtype levels in the neocortex and hippocampus, and with a restoration of expression of the mitochondrial marker cytochrome c oxidase in surviving neurons. In the APP/PS1 mice, NIr treatment was associated with a reduction in the size and number of amyloid-β plaques in the neocortex and hippocampus.
Conclusions: Our results, in two transgenic mouse models, suggest that NIr may have potential as an effective, minimally-invasive intervention for mitigating, and even reversing, progressive cerebral degenerations.
This is wild! I had no idea tetracycline antibiotics could have anti-amyloidogenic effects. Hope there is some further digging on this, and soon
Walter do you think natural substances like Serrapeptase or Nattokinase would be helpful? I believe I've read that they both break down fibrin (or something to that effect).
Though the question was not for me I believe yes both for bromelain and nattokinase.
I have proposed nattokinase (and consuming natto) for many in acute covid since 2020.
I am a neuroimmunology researcher turned anti-covid fanatic, and I regularly work in vitro with the virus.
Only 40% of the Japanese consuming natto enjoyed it. Must tast terrible :-) Nattokinase supplement sounds better. Could you please elaborate on what effect you see from bromelain and nattokinase? Must be significant since you recommend them. Other things you recommend that you see have positive effects?
The effects of a healthy and reinforced microbiome are paramount. SCV/2, as in FIP, stays in the gut. A healthy bacterial flora helps elimination of that, and trains the immune system properly. Natto is bad taste
https://f1000research.com/articles/11-292
https://f1000research.com/articles/10-370
On the other hand, these proteolytic enzymes might cleave i) fibrin ii) the spike itself. But in all cases, the changes in eating habits must turn towards fermented food (sauerkraut, yogurt etc.) and high and accessible flavonoid diet.
Natto tastes great imo. My kids like it as much as maguro
Very interesting papers, thank you. I was confused when some people had GI issues from C19. This makes sense now.
https://www.news-medical.net/news/20210521/Can-SARS-CoV-2-trigger-amyloidosis.aspx
https://pubmed.ncbi.nlm.nih.gov/32277967/
Missing you on twitter, but happy I found you on here
Bromelain also possible?
Has Dr Resia Pretorius tried this yet?
Impact of the Flavonoid Quercetin on β-Amyloid Aggregation Revealed by Intrinsic Fluorescence
https://pubs.acs.org/doi/full/10.1021/acs.jpcb.2c02763
Neuroprotective Effects of Quercetin in Alzheimer’s Disease
"... In addition to its antioxidant properties, it inhibits the fibril formation of amyloid-β proteins, counteracting cell lyses and inflammatory cascade pathways"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023116/
Quercetin binding accelerates prion fibrillation into proteinase sensitive and loosely structured amyloids
"...Prion diseases are carried out when accumulated PrPSc cannot be degraded efficiently. In human brain, PrPSc largely accumulates in astrocytes and microglia. The accumulated PrPSc can be cleared by phagocytosis. After PrPSc infection, microglia would enhance activity of phagocytosis by astrocyte-derived milk fat globule-epidermal growth factor 8 to remove PrPSc. When PrPSc clearance by microglia is inefficient, microglia would be activated by accumulated PrPSc and would consequently produce proinflammatory mediators resulting in neuron damage. As we found that quercetin binds to PrP and enhances the proteinase sensitivity of PrP fibrils, quercetin can potentially increase the clearance of PrPSc to prevent microglia activation and following neuroinflammation."
https://www.sciencedirect.com/science/article/pii/S0753332222005662
Quercetin inhibits amyloid fibrillation of bovine insulin and destabilizes preformed fibrils
https://www.sciencedirect.com/science/article/abs/pii/S0006291X11019693
A further investigation concerning correlation between anti-fibrotic effect of liposomal quercetin and inflammatory cytokines in pulmonary fibrosis
https://pubmed.ncbi.nlm.nih.gov/20510684/
Anti-fibrosis activity of quercetin attenuates rabbit tracheal stenosis via the TGF-β/AKT/mTOR signaling pathway
https://pubmed.ncbi.nlm.nih.gov/32179074/
The dietary antioxidant quercetin reduces hallmarks of bleomycin-induced lung fibrogenesis in mice
https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-020-1142-x
Quercetin Enhances Ligand-induced Apoptosis in Senescent Idiopathic Pulmonary Fibrosis Fibroblasts and Reduces Lung Fibrosis In Vivo
https://www.atsjournals.org/doi/full/10.1165/rcmb.2017-0289OC
Quercetin Shows the Pharmacological Activity to Simultaneously Downregulate the Inflammatory and Fibrotic Responses to Tissue Injury in Association with its Ability to Target Multi-Kinases
https://www.karger.com/Article/Abstract/490417
Doxycycline has been tried in cardiac amyloidosis and it is much more widely available.
I wonder if minocycline is much more effective than doxycycline.
where do you see it is being used in China?