I’m going through my third covid and, this time, I was faster and took IVM, zinc and Quercetin, from the first moment, together with vitamin D+K and 1mg melatonin, per kilo weight. That’s 50mg per day. And it’s going much better than the other two times. 🤗
Same here, Monica. The first year I was on HCQ, then went on quercetin and stayed on it to this day. In combination with Vitamin C, D, K and zinc, I have not had so much as a sniffle.
Dr Zelenko was shocked when it rapidity became clear that pandemic stopping early outpatient treatment was being sabotaged and suppressed via a long planned premeditated plan (along with suppression and sabotage of real covid prevention and real treatment for more severe stages of covid). He detailed the components and actors involved in this plan and researched and quickly came up with Quercetin as a 2ed place substitute to replace the zinc ionophore activity of the verboten / banned hydroxychloroquine in his initial covid early treatment protocol. Other Quercetin benefits and properties became known
Thanks to Dr Zelenko, Quercetin and zinc were the first purchases I made for my covid early treatment kit in 2020. I read up and found Quercetin can be hard to absorb and is rapidly eliminated with a sharp 8 hour bell shaped absorption and elimination curve which suggested to me 3 times a day dosing and I found out absorption can be increased "at home"
TO INCREASE ABSORPTION of quercetin and hard to absorb "herbs". "In Ayurvedic medicine you take remedies together with ghee and honey - fat and sugar." (Elizabeth)
From some reading I am thinking that some? basic simple process of coating with a sugar and then a fat? or a fat then a sugar? or all at once? would substantially increase absorption of many harder to absorb herbs and the like.
"While searching to find how to increase absorption of quercetin I found two patents. The first is an Indena SpA patent concerning "Quercefit"- "Quercetin Phytosome" In their earlier application documents ( only the final 2020 patent seems easily available now) they made an interesting revelation that a simple mechanical mixture of quercetin and maltodextrin or fructose (or other sugar) and lecithin (they use sunflower) in the range of 1-1-1 or any number of ratios increased absorption by 10 times while their lysosomal/phytosome product where they dissolve all in 190 proof ethanol which, at that time, they said increased absorption by 20 times. Now in the final document they claim that that their full process increases absorption by 50 times and they make no mention of the efficacy of the simple mechanical mixture but they do put a graph at the very beginning of the document which shows the low absorption of quercetin, the higher absorption of the :"physical mixture" (mechanical mixture) and the highest absorption of their "solid dispersion" which is their alcohol dissolved and dried "phytosome product Quercefit. That graph is best seen in the pdf US20200.... They say the use of the "sugar" is important.
A mortar and pestle is the obvious choice. I first used the back of a tablespoon against a plate to grind together the quercetin and the maltodextrin (sugar) then the lecithin.
I have since dissolved the "sugar" (nutricost organic maltodextrin "TapiOK" brand) in a bit of water then mixed in the harder to absorb "herb" then mixed in the Now brand sunflower lecithin then added olive oil. I wonder would it be better to dry the maltodextrin herb lecithin mix then add olive oil? Dissolving the maltodextrin does seem more effective way to "attach" the "sugar", and lecithin does attach to both water and fat and may, then, help present to a fat receptive absorption site in the body as does the maltodextrin absorb easily into the body as per its use by elite long distance runners (some like straight maltodextrin and some like 3 parts maltodextrin and 1 part fructose in water +++ for fuel and hydration during the run)
"Additional and related Surprising observations include that a combination of quercetin, vitamin B3. and vitamin C maintains quercetin levels in plasma up to five times those of quercetin alone or a combination of quercetin..." " In one aspect, the invention features a composition containing quercetin, vitamin B3, and vitamin C, in which a weight ratio between quercetin, vitamin B3, and vitamin C is 1:0.02-1:0.2-2.5.
Cut to the chase - If chosen Hydroxychloroquine administration for most treatment of covid IS BEST DONE VIA NEBULIZATION for exceptionally rapid effect bringing high levels of HCQ to the target areas with very little systemic absorption hence with very little to no systemic side effects. HCQ pills can also be taken if systemic distribution is also sought.
Dr. Zelenko's last HCQ gift to us, shortly before his passing, was clinically demonstrated nebulization of HCQ for the treatment of people sick with covid.
David E. Scheim, PhD did the gumshoe work working out the details showing doses , amount absorbed , lung tissue concentrations which show that 1 or 2 or so many HCQ pills can be simply converted to HCQ nebulization solution, at home, then nebulized to rapidly achieve the the same lung tissue concentrations as many more pills taken over numbers of days. .
"Nebulized Hydroxychloroquine for COVID-19 Treatment: 80x Improvement in Breathing" Vladimir Zelenko M.D
Nebulized hydroxychloroquine as 150 mg HCQ (amount of hcq in one 200 mg pill) in 6 ml (25 mg/ml) of isotonic sterile solution within the first five (5) days of COVID-19 symptoms (" Nebu HCQ ") has resulted in immediate improvement (<1 hour after use) in breathing in COVID-19 infected patients. Nebu HCQ served as a rescue medication with an 80x improvement in time and efficiency when compared to HCQ tablet (400-600 mg per day) combination therapy or Ivermectin combination therapy. No adverse events were reported outside of a bitter taste that quickly subsided. Average time of clinical improvement of pulmonary compromise precipitated by Covid 19 Covid-19 is primarily spread through the respiratory system and may result in significant pulmonary complications. Left untreated, a subset of patients will progress to acute respiratory distress syndrome (ARDS) and/or pulmonary infarcts. Oral HCQ and Ivermectin combination therapies have proven to be effective prehospital treatments of Covid-19 and its associated complications. However, treatment with oral HCQ may take an average of 80 hours to achieve significant clinical improvement as well as 3-7 days to achieve optimal alveolar concentration of medication. [3] Nebu HCQ administered as microdroplets directly to the lungs achieves optimal alveolar concentration in approximately one (1) hour and is associated with faster clinical improvement, reduction in pulmonary complications and a reduction in medical costs. The clinical data presented in this paper was generated through the routine practice of medicine and is considered "Real World Evidence" according to the 21st Century Cures Act. [4] Innovation Dr. Zelenko notes that ACE2 Technology LLC ("ACE2") developed Nebu HCQ and that Dr.... ... ...
Nebulized hydroxychloroquine plus oral azithromycin for COVID-19 treatment: from days to hours for optimal lung tissue concentrations and viral immobilization
David E. Scheim, PhD
"Abstract
Background. More than 3,300 COVID-19 patients treated at southeast France’s main COVID-19 treatment hospital with hydroxychloroquine (HCQ) and azithromycin (AZ) had a death rate one-sixth the world average. But the unusual pharmacology of HCQ presents a key limitation. Optimal tissue levels can only be accrued with 5-10 days of oral dosage. Thus, HCQ has performed well for early and mixed-stage COVID-19 patients but has exhibited marginal utility in advanced stage cases.
Proposed combination treatment of nebulized HCQ and oral azithromycin. Drug delivery of HCQ through inhalation of nebulized microdroplets will achieve, in hours, lung tissue concentrations equivalent to those accrued over days of oral dosage. Nebulizers are simple, inexpensive and widely available drug delivery devices, and minimal risks of local lung toxicities are indicated for such HCQ drug delivery. Furthermore, HCQ is effective in blunting the damaging effects of pro-inflammatory cytokines in the lungs. The combination treatment of nebulized HCQ along with oral AZ and possibly also ivermectin and zinc could provide a rapid reversal of the progression of COVID-19 both in the respiratory tract and in other body tissues."
my note:I expect nebulization of such small amounts of HCQ, as is needed in this application, overcomes virtually all the adverse event considerations concerning HCQ - even the concerns of HCQ use by those with G6PD and without incurring long QT risk in the vulnerable subset of people with HCQ associated risk for long QT. . G6PD link https://my.clevelandclinic.org/health/diseases/22556-g6pd-glucose-6-phosphate-dehydrogenase-deficiency note: Professor Didier Raoult was screening for G6PD and all wore wrist positioned monitors for long QT in his oral HCQ trials with thousands of patients.
Note: I bought the Philips Respironics InnoSpire Elegance compressor nebulizer system which is the 100% duty cycle version of the 50% duty cycle jet nebulizer system that Scheim used.
Dr. Zelenko, bless his wonderful soul, put out a video that got me started on quercetin and zinc. He explained zinc's anti-viral effects, provided it has a zinc ionophore to get past the cell membrane. HCQ and IVM were his original ionophores of choice (but we all know what happened there). Then he found quercetin is also a zinc ionophore, which is cool, because neither zinc nor quercetin require a prescription.
The video was in 2021. I've been taking the combo daily, ever since. Since then I've never had covid, nor any other cold or flu for that matter -- at least none that "took". Sometimes I think I have one coming on, but then it just passes before any real symptoms start. I'm sorry to say that no one else around me cares to give it a try, so they all keep getting sick.
So it's great to know of these additional benefits, and also that you're still working on amassing this monumental and important body of work, Mr. Walter M. Chesnut. I do believe you will go down in medical history, some day.
I have used quercitin and zinc since almost the beginning with great results, one of each in the morning and repeat in the evening every time I feel anything coming on. along with gargle and nasal spray. I havn't been sick / symptomatic with anything for more than a few hours for 4 yrs now
I had covid at the beginning of April 2020, my wife had it around the last week of March about 10 days before me. We took the early treatment protocol by Dr. Vladimir Zelenco. I saved the protocol: For low risk patients he said the following: 1. Rest, oral fluids. 2 OTC Quercetin 500mg 2 a day for 7 days with vitamin C 1000mg or OTC Epigallocatechin-gallate (EGCG) 400mg once a day for 7 days. 3. Elemental Zinc 50mg once a day for 7 days. 4. close followup with doctor.
This low risk protocol was all we needed and we were fine in about 10 days from onset (I was in my 60s, my wife in her 70s).
For higher risk people - older and/or with comorbidities he added Hydroxychloroquine 200mg 2X a day, and Azithromycin 500mg 1X a day for 5 days, or Doxycycline 100mg 2x a day for 7 days.
He also added additional treatment options: 1. Ivermectin 6mg 2x a day for 1 day Budesonide 1mg/2cc solution via nebulizer 2X a day for 7days 3. Dexamethasone 6mg 1x a day 4. blood thinners (i.e. Lovenox) 5. Home O2 6. Home IV fluids. He always admonished: Keep patients out of the hospital.
So we can see that Quercetin has been recommended almost since the beginning of the outbreak of covid.
I don't know if quercetin was a factor but I recovered much faster from my second bout with COVID (last week when I was taking quercetin) than I did from the first time in October 2022 when I wasn't taking quercetin. The first time I had a high temperature and had symptoms for a week (after taking the second booster only a couple months before). This time I had a much lower temp that lasted only a day.
Yes! I found Quercetin powerfully helpful in my recovery from longhaul Covid back in 2021. Quercetin is on of my top four favorite anti-amyloids. I agree with your thoughtful assessment. A thousand thanks for sharing this news so enthusiastically! I’ve been encouraging everyone I know to please take Quercetin.
I’m going through my third covid and, this time, I was faster and took IVM, zinc and Quercetin, from the first moment, together with vitamin D+K and 1mg melatonin, per kilo weight. That’s 50mg per day. And it’s going much better than the other two times. 🤗
I remember the late Dr. Zelenko recommending quercetin and zinc.
I have been taking quercetin for a couple of years and have not had the flu since 2019 December 10.
Same here, Monica. The first year I was on HCQ, then went on quercetin and stayed on it to this day. In combination with Vitamin C, D, K and zinc, I have not had so much as a sniffle.
Quercetin is a nice little gun to shoot the Zinc into cells for protection. Using it for years, now, for everybody coming to our house.
You ask the rhetorical "Quercetin" question - Were we denied knowledge of a potential lifesaver?
First the historic Zelenko letter "March 23, 2020" "To all medical professionals around the world:" https://docs.google.com/document/d/1SesxgaPnpT6OfCYuaFSwXzDK4cDKMbivoALprcVFj48/mobilebasic?usp=gmail - then
Dr Zelenko was shocked when it rapidity became clear that pandemic stopping early outpatient treatment was being sabotaged and suppressed via a long planned premeditated plan (along with suppression and sabotage of real covid prevention and real treatment for more severe stages of covid). He detailed the components and actors involved in this plan and researched and quickly came up with Quercetin as a 2ed place substitute to replace the zinc ionophore activity of the verboten / banned hydroxychloroquine in his initial covid early treatment protocol. Other Quercetin benefits and properties became known
Thanks to Dr Zelenko, Quercetin and zinc were the first purchases I made for my covid early treatment kit in 2020. I read up and found Quercetin can be hard to absorb and is rapidly eliminated with a sharp 8 hour bell shaped absorption and elimination curve which suggested to me 3 times a day dosing and I found out absorption can be increased "at home"
TO INCREASE ABSORPTION of quercetin and hard to absorb "herbs". "In Ayurvedic medicine you take remedies together with ghee and honey - fat and sugar." (Elizabeth)
From some reading I am thinking that some? basic simple process of coating with a sugar and then a fat? or a fat then a sugar? or all at once? would substantially increase absorption of many harder to absorb herbs and the like.
"While searching to find how to increase absorption of quercetin I found two patents. The first is an Indena SpA patent concerning "Quercefit"- "Quercetin Phytosome" In their earlier application documents ( only the final 2020 patent seems easily available now) they made an interesting revelation that a simple mechanical mixture of quercetin and maltodextrin or fructose (or other sugar) and lecithin (they use sunflower) in the range of 1-1-1 or any number of ratios increased absorption by 10 times while their lysosomal/phytosome product where they dissolve all in 190 proof ethanol which, at that time, they said increased absorption by 20 times. Now in the final document they claim that that their full process increases absorption by 50 times and they make no mention of the efficacy of the simple mechanical mixture but they do put a graph at the very beginning of the document which shows the low absorption of quercetin, the higher absorption of the :"physical mixture" (mechanical mixture) and the highest absorption of their "solid dispersion" which is their alcohol dissolved and dried "phytosome product Quercefit. That graph is best seen in the pdf US20200.... They say the use of the "sugar" is important.
A mortar and pestle is the obvious choice. I first used the back of a tablespoon against a plate to grind together the quercetin and the maltodextrin (sugar) then the lecithin.
I have since dissolved the "sugar" (nutricost organic maltodextrin "TapiOK" brand) in a bit of water then mixed in the harder to absorb "herb" then mixed in the Now brand sunflower lecithin then added olive oil. I wonder would it be better to dry the maltodextrin herb lecithin mix then add olive oil? Dissolving the maltodextrin does seem more effective way to "attach" the "sugar", and lecithin does attach to both water and fat and may, then, help present to a fat receptive absorption site in the body as does the maltodextrin absorb easily into the body as per its use by elite long distance runners (some like straight maltodextrin and some like 3 parts maltodextrin and 1 part fructose in water +++ for fuel and hydration during the run)
the other patent US8440... helps inform the usefulness of taking quercetin with B3 and C. https://patents.google.com/patent/US8440704B2/en
"Additional and related Surprising observations include that a combination of quercetin, vitamin B3. and vitamin C maintains quercetin levels in plasma up to five times those of quercetin alone or a combination of quercetin..." " In one aspect, the invention features a composition containing quercetin, vitamin B3, and vitamin C, in which a weight ratio between quercetin, vitamin B3, and vitamin C is 1:0.02-1:0.2-2.5.
https://patents.google.com/patent/US20200206186A1/en?oq=US20200206186A1
https://patentimages.storage.googleapis.com/ab/aa/e9/41f67fcf738609/US20200206186A1.pdf
nebulized HCQ post follows as a reply
Cut to the chase - If chosen Hydroxychloroquine administration for most treatment of covid IS BEST DONE VIA NEBULIZATION for exceptionally rapid effect bringing high levels of HCQ to the target areas with very little systemic absorption hence with very little to no systemic side effects. HCQ pills can also be taken if systemic distribution is also sought.
Dr. Zelenko's last HCQ gift to us, shortly before his passing, was clinically demonstrated nebulization of HCQ for the treatment of people sick with covid.
David E. Scheim, PhD did the gumshoe work working out the details showing doses , amount absorbed , lung tissue concentrations which show that 1 or 2 or so many HCQ pills can be simply converted to HCQ nebulization solution, at home, then nebulized to rapidly achieve the the same lung tissue concentrations as many more pills taken over numbers of days. .
Zelenko's "Nebu HCQ" c19hcq.org/zelenko.html
"Nebulized Hydroxychloroquine for COVID-19 Treatment: 80x Improvement in Breathing" Vladimir Zelenko M.D
Nebulized hydroxychloroquine as 150 mg HCQ (amount of hcq in one 200 mg pill) in 6 ml (25 mg/ml) of isotonic sterile solution within the first five (5) days of COVID-19 symptoms (" Nebu HCQ ") has resulted in immediate improvement (<1 hour after use) in breathing in COVID-19 infected patients. Nebu HCQ served as a rescue medication with an 80x improvement in time and efficiency when compared to HCQ tablet (400-600 mg per day) combination therapy or Ivermectin combination therapy. No adverse events were reported outside of a bitter taste that quickly subsided. Average time of clinical improvement of pulmonary compromise precipitated by Covid 19 Covid-19 is primarily spread through the respiratory system and may result in significant pulmonary complications. Left untreated, a subset of patients will progress to acute respiratory distress syndrome (ARDS) and/or pulmonary infarcts. Oral HCQ and Ivermectin combination therapies have proven to be effective prehospital treatments of Covid-19 and its associated complications. However, treatment with oral HCQ may take an average of 80 hours to achieve significant clinical improvement as well as 3-7 days to achieve optimal alveolar concentration of medication. [3] Nebu HCQ administered as microdroplets directly to the lungs achieves optimal alveolar concentration in approximately one (1) hour and is associated with faster clinical improvement, reduction in pulmonary complications and a reduction in medical costs. The clinical data presented in this paper was generated through the routine practice of medicine and is considered "Real World Evidence" according to the 21st Century Cures Act. [4] Innovation Dr. Zelenko notes that ACE2 Technology LLC ("ACE2") developed Nebu HCQ and that Dr.... ... ...
Nebu HCQ Whitepaper_Scheim.docx https://docs.google.com/document/u/0/d/e/2PACX-1vR_ZkSoL1bJI_Hj75SKoqtjsnGUYC_xCQkIwHvHSoz3y45CBhn8w7BSlsboE1avPw/pub?urp=gmail_link&pli=1
Nebulized hydroxychloroquine plus oral azithromycin for COVID-19 treatment: from days to hours for optimal lung tissue concentrations and viral immobilization
David E. Scheim, PhD
"Abstract
Background. More than 3,300 COVID-19 patients treated at southeast France’s main COVID-19 treatment hospital with hydroxychloroquine (HCQ) and azithromycin (AZ) had a death rate one-sixth the world average. But the unusual pharmacology of HCQ presents a key limitation. Optimal tissue levels can only be accrued with 5-10 days of oral dosage. Thus, HCQ has performed well for early and mixed-stage COVID-19 patients but has exhibited marginal utility in advanced stage cases.
Proposed combination treatment of nebulized HCQ and oral azithromycin. Drug delivery of HCQ through inhalation of nebulized microdroplets will achieve, in hours, lung tissue concentrations equivalent to those accrued over days of oral dosage. Nebulizers are simple, inexpensive and widely available drug delivery devices, and minimal risks of local lung toxicities are indicated for such HCQ drug delivery. Furthermore, HCQ is effective in blunting the damaging effects of pro-inflammatory cytokines in the lungs. The combination treatment of nebulized HCQ along with oral AZ and possibly also ivermectin and zinc could provide a rapid reversal of the progression of COVID-19 both in the respiratory tract and in other body tissues."
This paper has blood plasma HCQ levels from nebulized HCQ "Nebulised Isotonic Hydroxychloroquine Aerosols for Potential Treatment of COVID-19" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399722/
my note:I expect nebulization of such small amounts of HCQ, as is needed in this application, overcomes virtually all the adverse event considerations concerning HCQ - even the concerns of HCQ use by those with G6PD and without incurring long QT risk in the vulnerable subset of people with HCQ associated risk for long QT. . G6PD link https://my.clevelandclinic.org/health/diseases/22556-g6pd-glucose-6-phosphate-dehydrogenase-deficiency note: Professor Didier Raoult was screening for G6PD and all wore wrist positioned monitors for long QT in his oral HCQ trials with thousands of patients.
Note: I bought the Philips Respironics InnoSpire Elegance compressor nebulizer system which is the 100% duty cycle version of the 50% duty cycle jet nebulizer system that Scheim used.
my.clevelandclinic.org
What Is G6PD Deficiency?
Dr. Zelenko, bless his wonderful soul, put out a video that got me started on quercetin and zinc. He explained zinc's anti-viral effects, provided it has a zinc ionophore to get past the cell membrane. HCQ and IVM were his original ionophores of choice (but we all know what happened there). Then he found quercetin is also a zinc ionophore, which is cool, because neither zinc nor quercetin require a prescription.
The video was in 2021. I've been taking the combo daily, ever since. Since then I've never had covid, nor any other cold or flu for that matter -- at least none that "took". Sometimes I think I have one coming on, but then it just passes before any real symptoms start. I'm sorry to say that no one else around me cares to give it a try, so they all keep getting sick.
So it's great to know of these additional benefits, and also that you're still working on amassing this monumental and important body of work, Mr. Walter M. Chesnut. I do believe you will go down in medical history, some day.
Why save lives? The Aim was population control.
There’s been a lot of talk of DMSO again… I’d be interested to see if any of these therapeutics worked. Better combine with DMSO.
Walter, what dose is recommended?
Yes, also interested in what dosing seems appropriate.
Depends...I've been taking Quercetin Zinc for three years now...
I have used quercitin and zinc since almost the beginning with great results, one of each in the morning and repeat in the evening every time I feel anything coming on. along with gargle and nasal spray. I havn't been sick / symptomatic with anything for more than a few hours for 4 yrs now
Quercetin thins your blood. If you are on blood thinners be careful.
I had covid at the beginning of April 2020, my wife had it around the last week of March about 10 days before me. We took the early treatment protocol by Dr. Vladimir Zelenco. I saved the protocol: For low risk patients he said the following: 1. Rest, oral fluids. 2 OTC Quercetin 500mg 2 a day for 7 days with vitamin C 1000mg or OTC Epigallocatechin-gallate (EGCG) 400mg once a day for 7 days. 3. Elemental Zinc 50mg once a day for 7 days. 4. close followup with doctor.
This low risk protocol was all we needed and we were fine in about 10 days from onset (I was in my 60s, my wife in her 70s).
For higher risk people - older and/or with comorbidities he added Hydroxychloroquine 200mg 2X a day, and Azithromycin 500mg 1X a day for 5 days, or Doxycycline 100mg 2x a day for 7 days.
He also added additional treatment options: 1. Ivermectin 6mg 2x a day for 1 day Budesonide 1mg/2cc solution via nebulizer 2X a day for 7days 3. Dexamethasone 6mg 1x a day 4. blood thinners (i.e. Lovenox) 5. Home O2 6. Home IV fluids. He always admonished: Keep patients out of the hospital.
So we can see that Quercetin has been recommended almost since the beginning of the outbreak of covid.
You are correct, Dr. Zelenko said EGCG (also over the counter) will do the job too.
Taking soy lecithin helps the gastric absorption of quercetin.
Quercetin is a zinc ionophore (as is hydroxychloroquine).
Intracellular zinc inhibits coronavirus production.
When I got Delta at the end of 2021, I took ivermectin, zinc, quercetin and lecithin and felt essentially normal in 3 days.
Unfortunately, I stopped after 5 days of treatment, rebounded, and was just in purgatory for another 10 days or so, despite resuming treatment.
I don't know if quercetin was a factor but I recovered much faster from my second bout with COVID (last week when I was taking quercetin) than I did from the first time in October 2022 when I wasn't taking quercetin. The first time I had a high temperature and had symptoms for a week (after taking the second booster only a couple months before). This time I had a much lower temp that lasted only a day.
Yes! I found Quercetin powerfully helpful in my recovery from longhaul Covid back in 2021. Quercetin is on of my top four favorite anti-amyloids. I agree with your thoughtful assessment. A thousand thanks for sharing this news so enthusiastically! I’ve been encouraging everyone I know to please take Quercetin.