58 Comments
Nov 5, 2022Liked by Walter M Chesnut

I'm looking forward to Friday for more than Malone's "Friday Funnies" LOL. I've been using melatonin for a long time so no problem there. It's been on the protocols over at flccc.net so I wonder if this is the pathway (or one of) that it works? Great catch Walt.

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good one! i watch him to see whats coming next ... he is talking about some constitutional amendments and redrawing of maps in the US ... sort of revolution in the making, a tell sign of all these guys (and there are some A rated types, good ones) is when they start talking about coming Civil war whatever that means.

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Civil war is not the way.

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Nov 5, 2022·edited Nov 6, 2022

exactly. walter types are a gem if we are lucky ...

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Nov 5, 2022Liked by Walter M Chesnut

Thank you. After another day of vascular surgery mishaps I’ll gladly take some melatonin tonight. God speed.

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Nov 5, 2022Liked by Walter M Chesnut

Melatonin helps to uncouple the mitochondria . Take a closer look at the task of UCP1.

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Uncouple... could you explain a little more?

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https://wmcresearch.substack.com/p/ketogenic-diets-deplete-epinephrine/comment/10215700

1. Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease - https://www.sciencedirect.com/science/article/abs/pii/S0091302212000295 - "...epidemiological associations have been made between low vitamin D and psychiatric disorders not typically associated with abnormalities in brain development such as depression and Alzheimer’s disease. Once again the preclinical findings revealing that vitamin D can regulate catecholamine levels and protect against specific Alzheimer-like pathology increase the plausibility of this link..."

2. Vitamin D Supplementation Improves Cardiovascular Response to Head Up Tilt in Adolescents Suffering from Syncope - https://www.ahajournals.org/doi/10.1161/hyp.72.suppl_1.P396 - "...Compared to baseline, vitamin D supplementation reduced the HR elevation post HUT and reduced NE/Epi baseline levels..."

3. Effects of bioflavonoids on catecholamine biosynthetic activity in the adrenal gland: In vitro studies using partially purified tyrosine hydroxylase and chromaffin cell cultures - https://pubmed.ncbi.nlm.nih.gov/20504598/ - "...The findings presented here suggest that quercetin may inhibit catecholamine biosynthesis..."

4. Zinc controls cell pores to regulate storage and release of catecholamine - https://cen.acs.org/articles/95/i13/Zinc-controls-cell-pores-regulate.html - "...They found that cultured adrenal cells treated with zinc store less catecholamine than untreated cells. Even though the treated cells store less, they actually release the same amount of catecholamine as the untreated cells because they’re releasing nearly all of what they have taken in. That release also occurs much more slowly than the release from untreated cells..."

5. Vitamin C prevents stress-induced damage on the heart caused by the death of cardiomyocytes, through down-regulation of the excessive production of catecholamine, TNF-α, and ROS production in Gulo(−/−)Vit C-Insufficient mice - https://www.sciencedirect.com/science/article/abs/pii/S0891584913003675

6. Curcumin suppresses gelatinase B mediated norepinephrine induced stress in H9c2 cardiomyocytes - https://pubmed.ncbi.nlm.nih.gov/24116115/

7. Neuromodulatory effect of curcumin on catecholamine systems and inflammatory cytokines in ovariectomized female rats - https://pubmed.ncbi.nlm.nih.gov/33098686/

8. (–)-Epigallocatechin-3-O-gallate (EGCG) attenuates the hemodynamics stimulated by caffeine through decrease of catecholamines release - https://link.springer.com/article/10.1007/s12272-016-0757-1

9. Melatonin regulates catecholamine biosynthesis by modulating bone morphogenetic protein and glucocorticoid actions - https://www.sciencedirect.com/science/article/abs/pii/S0960076016301728

10. Sympathetic Activity Increases With Obesity in Hypertensive Patients - https://www.ahajournals.org/doi/10.1161/hyp.70.suppl_1.114 - "...Increase in BMI is associated with increasing dopamine, catecholamines and metanephrines indicative of progressive SANS activation..."

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look at Berberine too. Very effective at lowering blood glucose, like keto diets.

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Yes!

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Magnesium salts seem to reduce catecholamine induced arythmia according to this

https://pubmed.ncbi.nlm.nih.gov/1665982/

And most people are Magnesium deficient

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Thank you Walter. Melatonin has been on my radar for a while now. Even coffee is a source via phytomelatonin, certainly elevates it's importance for further study.

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That is the best news I have heard today!

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I take it as part of the FLCCC protocol whenever I've been exposed to someone who's got COVID or been recently jabbed. So far, so good. It doesn't help me sleep, though.

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I take 10mg time release melatonin at night. Much more than is recommended. I take magnesium l-threonate and NAC with it. I usually sleep very well, as long as I have no more than 2 cups of tea in the morning. Most of the FLCCC protocol you can take every day, like the vitamins and quercetin.

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I do all all those things (except a different variant of magnesium, so I will look into that; I drink coffee, but not after 2pm) but nothing helps. These days I spend as much on supplements as food, no exaggerating.

(In all fairness, I should give some context for my insomnia: My dad has stage 4 cancer, my brother recently had his baby twins jabbed with the C19 shot, everyone I love has been jabbed at least twice so I'm bracing myself for losing them all within the next few years, the economy is in the dumpster, we're on the verge of WW 3, etc. Cute animal videos help calm me down, as well as long walks and journalling, but sleep eludes me.)

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ok,ms C, this ol mechanic's take is- use mg transdermally...you will never reach a therapeutic dose orally because it can't be absorbed ...esp since your digestion/immune system is tanking under all the family/global stuff...you might give mg oil a shot...even if you don't notice a change, keep rubbing it in

& rub some coconut oil over it... the mg oil Really helps ...800 different processes in the body! cheers

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I remember getting magnesium cream years ago, thanks for reminding me! Another option I'd forgotten about is Epsom salts for baths or soaking feet.

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Epsom salt bath is a great idea. Alternatively do you have any mineral hot springs near your house...

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No hot springs nearby, unfortunately. That would be a wonderful way to get magnesium and unwind.

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I take four melatonin (10mg each) which helps a ton. You're not going to lose them all. No way. I keep telling myself they can't all get sick or pass away. No way. Think about it... some of the lots had to have been transported improperly which means the active ingredients wouldn't be active (as they didn't stay cold enough). This explains why some of my friends are so sick post-jab and some have had multiple shots and never have even a sore arm.

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Thanks, Frances, I pray that you're right. I'm so glad to hear that some of your friends are doing okay. I also have a handful who seem to be fine so far, though some have had C19. Another thing that gives me hope is that vaccines in general aren't as effective if someone is overweight, so I'm actually grateful that some of my loved ones are carrying extra pounds.

With the exception of my parents, everyone I know is still lining up for boosters. They don't question the official narrative at all, which baffles me. The government where I am (BC, Canada) is pushing the jabs and talking about reintroducing mask mandates, which they wholeheartedly approve of even though the government admits death rates are steeply down.

I'm only tasking 10mg of Melatonin each night, so I will try upping the dosage.

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I'm sorry Claudia. A lot of us are right there with you!

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Claudia, look up the work of Huberman Labs on youtube. Dr Huberman did a longish interview with a sleep expert.

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Thanks for the tip, Frances, I'll do that.

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Claudia, Dr Huberman's suggestions are very good re getting exposed to the morning sun light or alternative light if living in cold climate, also having subdued light in the home in evenings; but, I don't think he recommends melatonin, which I've had to ignore.

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Yeah, I'd have to ignore the part about Melatonin as well since it's part of the FLCCC protocol. That's okay, because one thing I've been reminded of over and over again during the last few years: Don't let perfect be the enemy of the good!

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When I started taking 2 drops of high quality nano cbd at bedtime I started sleeping so much more soundly. Produced and sold by Dr. Stephen Cherniske @ www.TheHealthySkeptics.com

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Thanks, I'll look into this. There are lots of local stores that sell CBC oil, thank goodness (I'm in Canada, so it's best to get it within the country).

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😢🌺🌺🌺

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Have you seen this? You can buy it online. The video shows it destroy a cancer tumor in 20mins.

https://twitter.com/ANT159694954/status/1580619752661078016?s=20&t=dkMYRgEN7mEV16KrPYUvCg

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Melatonin 10 mg has been used safely in the treatment of cluster headache.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012937/

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I take much more and can not notice anything negative. On the contrary, better than before COVID. We most likely just need to combine the right things. Very good also against Long covid.

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Dr Frank Shallenberger uses high dose melatonin for patients requiring it based on the research of Prof. Russel Reiter, PhD. Pdf online as well as youtube info.

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I get a paradoxical effect - I sleep less well.

I abandoned it in favor of other things, but wonder if I should just take it in the morning!

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you probably have nothing to lose by trying it that way

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Nov 5, 2022·edited Nov 5, 2022

Walter... This makes a lot of sense to me. Melatonin has strong anti-inflammatory effects. Your research posts have really triggered me... Though I am an Ophthalmologist (cataracts, etc., x40 years), I veered into cannabis medicine in 2012 and have now seen thousands of patients in two states. Cannabidiol (CBD) and other variants (CBN, CBG, THC, etc.) will work similarly , I think. I did a quick search and found many papers on this topic, but need your research skills to flesh it out! I encourage all of my patients to take quality CBD as a supplement - anti-inflammatory, neuro-protective, anti-cancer, anti-Alzheiner's, helps regulate endocrine function and mood. In the US, CBD products with less that 0.3% THC are unregulated and legal in all 50 states, so can be ordered online. The biggest problem is the lack of regulation - half the CBD in the market is probably bogus. Add this to your research pile to sort through for dealing with catecholamines.

Part of the Plandemic plan, IMO, is to promote high levels of fear and anxiety through the population as this not only enhances compliance, but effectiveness of the bioweapon. Nothing drives a herd more than FEAR. PORN. 24/7/365!

Paper example: https://pubmed.ncbi.nlm.nih.gov/7391971/

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Just an anecdotal thing to report. My son has insomnia (like my whole family) and his friend suggested some hemp derived Delta 8 vape product to help him sleep. He got it at a store legally and tried it one night. He ended up calling 911 in the middle of the night, his body's reaction to it was so severe. Three weeks later he developed some new cardio issue. We still don't know if the Delta 8 could have caused it, but one of the crews on the ambulances we've had to call several times told us they've recently run more calls for Delta 8 reactions than they do for people's adverse reactions to pot. I agree... nobody's making sure these products contain what they claim to contain and are 'safe.' (I've actually grown to hate the word safe since this covid thing began.)

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When I started taking 2 drops of high quality nano cbd at bedtime I started sleeping so much more soundly. Produced and sold by Dr. Stephen Cherniske @ www.TheHealthySkeptics.com

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Yes... Though some people are actually stimulated by CBD, so one needs to generally not take it right before bed as it may delay sleep in some individuals. Compounds with melatonin or CBN can help with sleep for sure...

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Big Pharma? Big (dark) Chocolate! (lol)

Metabolic Effects of Dark Chocolate Consumption on Energy, Gut Microbiota, and Stress-Related Metabolism in Free-Living Subjects - https://pubs.acs.org/doi/abs/10.1021/pr900607v - "...Dark chocolate reduced the urinary excretion of the stress hormone cortisol and catecholamines and partially normalized stress-related differences in energy metabolism..."

Dark Chocolate Takes Bite Out of Stress - https://www.webmd.com/balance/stress-management/news/20091113/dark-chocolate-takes-bite-out-of-stress - ("...conducted by researchers at the Nestle Research Center...")

Heart Health Benefits of Dark Chocolate - https://intermountainhealthcare.org/blogs/topics/heart/2015/02/heart-health-benefits-of-dark-chocolate/ - "...Dark chocolate has been shown to reduce the levels of cortisol and epinephrine..."

Effects of dark chocolate consumption on the prothrombotic response to acute psychosocial stress in healthy men - https://www.thieme-connect.com/products/ejournals/abstract/10.1160/th14-05-0450 - "...our findings indicate that a single consumption of flavonoid- rich dark chocolate blunted the acute prothrombotic response to psychosocial stress, thereby perhaps mitigating the risk of acute coronary syndromes triggered by emotional stress..."

7 Foods That Are High in Magnesium (via Cleveland Clinic) - https://health.clevelandclinic.org/foods-that-are-high-in-magnesium/ - "Dark chocolate (70-85% cocoa): 1 oz. = 64 milligrams of magnesium (16% RDA)"

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Another excellent, informative and highly informed post from Walter. My ex was an airline Captain flying long haul - he took it every day and swore by its abilities to assist with “time zone changes and their effects upon his mind and body” l have not so far tried it .. am on many other supplements, l often wonder what the effects are of taking them all together too - does one affect another, such as in “pharma” making it less stable or giving side effects? Anyway, off to buy some Melatonin Walter and again a huge thank you for your much anticipated and appreciated articles! Substack wouldn’t be the same without you! Wishing you a good weekend!

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Herb-herb and drug-herb interaction analysis is a huge unmet need.

Some are known (like don't take magnesium within two hours of medication as it can affect absorption), but most are not.

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Terrific!

Doris Loh is an esteemed, really prominent ascorbic acid and melatonin researcher. I just posted your article on her Facebook page!

https://www.facebook.com/groups/1406779789714470

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Then you can deal with the topic of light next Friday. Take a closer look at the Nobel Prize for Chemistry 2015 and the Nobel Prize for Medicine 2009. There is a mistake in the one for medicine. Find it

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It's a pity that melatonin in Canada and Australia is considered a medicine and not a dietary supplement as in the USA. Dr. prescription required for compounding chemist/pharmacist.

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Which could mean Walter is on the right track. There is legislation pending in the US brought forward by Democratic Senator Dick Durbin to regulate all supplements.

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I love this post! Melatonin feels good for me. I have problems with GABA, though.

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Hi and thank you for responding. It was a “mix” of supplements that my naturopath suggested to me .. However, l have had my own concerns about this and believe you may be right. I know that K2 is important, so what would you suggest? I am grateful for any suggestions you may have. I am dealing (or attempting to deal with) Multiple Chemical Sensitivities, Multiple Food Allergies, EMR Sensitivities and have Mast Cell Activation Syndrome. Life is quite “challenging” but l do try to keep my somewhat crazy sense of humour .. most days! I was doused in Glyphosates about 10 years ago whilst out walking my dogs in a low country lane. A farmer was spraying his fields and gave little thought to the possibility that someone may be walking along the lane - so swing arm of spraying machine came over my head - killed one of my dogs outright and almost me .. following several weeks in hospital and goodnsss only knows what they pumped into me .. l came home to find that slowly l became more and more allergic to … everything .. it is a “hot political topic” as so many people, the current estimate being 1 in 3, are developing auto immune conditions. I was not vax’d and will not take the flu Vax either as “they” are in the process of combining the two as you may know .. So .. my GP will only give me the 1000yd stare when l endeavour to “open up the conversation” on G and allergies .. which is why l sought a Naturopath. There are only 3 Consultant’s working in Britain who are prepared to work with these conditions - they are private but there is a two year wait. Thank you again for drawing this to my attention - any suggestions are gratefully received.

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Can you further enlighten me? I am am interested in the effects of taking supplements and their effects upon each other - l take Quercetin, Vit D3, Glutathione, Zinc, Iodine, Activated Charcoal with Vit K2, Vitamin B12, low dose Aspirin and Zeolite .. your thoughts, after picking yourself up from the carpet?

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Why the charcoal with k2? Wouldn’t that just block the k2 from being absorbed?

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Quercetin has multiple drug interactions. https://www.webmd.com/vitamins/ai/ingredientmono-294/Quercetin

Glutathione is not well absorbed, which is why many of us take N-acetyl cysteine, its precursor, instead.

Other than that, I don't know a source for checking multi-herb interactions.

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