I'm looking forward to Friday for more than Malone's "Friday Funnies" LOL. I've been using melatonin for a long time so no problem there. It's been on the protocols over at flccc.net so I wonder if this is the pathway (or one of) that it works? Great catch Walt.
1. Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease - https://www.sciencedirect.com/science/article/abs/pii/S0091302212000295 - "...epidemiological associations have been made between low vitamin D and psychiatric disorders not typically associated with abnormalities in brain development such as depression and Alzheimer’s disease. Once again the preclinical findings revealing that vitamin D can regulate catecholamine levels and protect against specific Alzheimer-like pathology increase the plausibility of this link..."
2. Vitamin D Supplementation Improves Cardiovascular Response to Head Up Tilt in Adolescents Suffering from Syncope - https://www.ahajournals.org/doi/10.1161/hyp.72.suppl_1.P396 - "...Compared to baseline, vitamin D supplementation reduced the HR elevation post HUT and reduced NE/Epi baseline levels..."
3. Effects of bioflavonoids on catecholamine biosynthetic activity in the adrenal gland: In vitro studies using partially purified tyrosine hydroxylase and chromaffin cell cultures - https://pubmed.ncbi.nlm.nih.gov/20504598/ - "...The findings presented here suggest that quercetin may inhibit catecholamine biosynthesis..."
4. Zinc controls cell pores to regulate storage and release of catecholamine - https://cen.acs.org/articles/95/i13/Zinc-controls-cell-pores-regulate.html - "...They found that cultured adrenal cells treated with zinc store less catecholamine than untreated cells. Even though the treated cells store less, they actually release the same amount of catecholamine as the untreated cells because they’re releasing nearly all of what they have taken in. That release also occurs much more slowly than the release from untreated cells..."
5. Vitamin C prevents stress-induced damage on the heart caused by the death of cardiomyocytes, through down-regulation of the excessive production of catecholamine, TNF-α, and ROS production in Gulo(−/−)Vit C-Insufficient mice - https://www.sciencedirect.com/science/article/abs/pii/S0891584913003675
10. Sympathetic Activity Increases With Obesity in Hypertensive Patients - https://www.ahajournals.org/doi/10.1161/hyp.70.suppl_1.114 - "...Increase in BMI is associated with increasing dopamine, catecholamines and metanephrines indicative of progressive SANS activation..."
Thank you Walter. Melatonin has been on my radar for a while now. Even coffee is a source via phytomelatonin, certainly elevates it's importance for further study.
I take it as part of the FLCCC protocol whenever I've been exposed to someone who's got COVID or been recently jabbed. So far, so good. It doesn't help me sleep, though.
Walter... This makes a lot of sense to me. Melatonin has strong anti-inflammatory effects. Your research posts have really triggered me... Though I am an Ophthalmologist (cataracts, etc., x40 years), I veered into cannabis medicine in 2012 and have now seen thousands of patients in two states. Cannabidiol (CBD) and other variants (CBN, CBG, THC, etc.) will work similarly , I think. I did a quick search and found many papers on this topic, but need your research skills to flesh it out! I encourage all of my patients to take quality CBD as a supplement - anti-inflammatory, neuro-protective, anti-cancer, anti-Alzheiner's, helps regulate endocrine function and mood. In the US, CBD products with less that 0.3% THC are unregulated and legal in all 50 states, so can be ordered online. The biggest problem is the lack of regulation - half the CBD in the market is probably bogus. Add this to your research pile to sort through for dealing with catecholamines.
Part of the Plandemic plan, IMO, is to promote high levels of fear and anxiety through the population as this not only enhances compliance, but effectiveness of the bioweapon. Nothing drives a herd more than FEAR. PORN. 24/7/365!
Metabolic Effects of Dark Chocolate Consumption on Energy, Gut Microbiota, and Stress-Related Metabolism in Free-Living Subjects - https://pubs.acs.org/doi/abs/10.1021/pr900607v - "...Dark chocolate reduced the urinary excretion of the stress hormone cortisol and catecholamines and partially normalized stress-related differences in energy metabolism..."
Effects of dark chocolate consumption on the prothrombotic response to acute psychosocial stress in healthy men - https://www.thieme-connect.com/products/ejournals/abstract/10.1160/th14-05-0450 - "...our findings indicate that a single consumption of flavonoid- rich dark chocolate blunted the acute prothrombotic response to psychosocial stress, thereby perhaps mitigating the risk of acute coronary syndromes triggered by emotional stress..."
Another excellent, informative and highly informed post from Walter. My ex was an airline Captain flying long haul - he took it every day and swore by its abilities to assist with “time zone changes and their effects upon his mind and body” l have not so far tried it .. am on many other supplements, l often wonder what the effects are of taking them all together too - does one affect another, such as in “pharma” making it less stable or giving side effects? Anyway, off to buy some Melatonin Walter and again a huge thank you for your much anticipated and appreciated articles! Substack wouldn’t be the same without you! Wishing you a good weekend!
Then you can deal with the topic of light next Friday. Take a closer look at the Nobel Prize for Chemistry 2015 and the Nobel Prize for Medicine 2009. There is a mistake in the one for medicine. Find it
It's a pity that melatonin in Canada and Australia is considered a medicine and not a dietary supplement as in the USA. Dr. prescription required for compounding chemist/pharmacist.
Hi and thank you for responding. It was a “mix” of supplements that my naturopath suggested to me .. However, l have had my own concerns about this and believe you may be right. I know that K2 is important, so what would you suggest? I am grateful for any suggestions you may have. I am dealing (or attempting to deal with) Multiple Chemical Sensitivities, Multiple Food Allergies, EMR Sensitivities and have Mast Cell Activation Syndrome. Life is quite “challenging” but l do try to keep my somewhat crazy sense of humour .. most days! I was doused in Glyphosates about 10 years ago whilst out walking my dogs in a low country lane. A farmer was spraying his fields and gave little thought to the possibility that someone may be walking along the lane - so swing arm of spraying machine came over my head - killed one of my dogs outright and almost me .. following several weeks in hospital and goodnsss only knows what they pumped into me .. l came home to find that slowly l became more and more allergic to … everything .. it is a “hot political topic” as so many people, the current estimate being 1 in 3, are developing auto immune conditions. I was not vax’d and will not take the flu Vax either as “they” are in the process of combining the two as you may know .. So .. my GP will only give me the 1000yd stare when l endeavour to “open up the conversation” on G and allergies .. which is why l sought a Naturopath. There are only 3 Consultant’s working in Britain who are prepared to work with these conditions - they are private but there is a two year wait. Thank you again for drawing this to my attention - any suggestions are gratefully received.
Can you further enlighten me? I am am interested in the effects of taking supplements and their effects upon each other - l take Quercetin, Vit D3, Glutathione, Zinc, Iodine, Activated Charcoal with Vit K2, Vitamin B12, low dose Aspirin and Zeolite .. your thoughts, after picking yourself up from the carpet?
I'm looking forward to Friday for more than Malone's "Friday Funnies" LOL. I've been using melatonin for a long time so no problem there. It's been on the protocols over at flccc.net so I wonder if this is the pathway (or one of) that it works? Great catch Walt.
Thank you. After another day of vascular surgery mishaps I’ll gladly take some melatonin tonight. God speed.
Melatonin helps to uncouple the mitochondria . Take a closer look at the task of UCP1.
https://wmcresearch.substack.com/p/ketogenic-diets-deplete-epinephrine/comment/10215700
1. Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease - https://www.sciencedirect.com/science/article/abs/pii/S0091302212000295 - "...epidemiological associations have been made between low vitamin D and psychiatric disorders not typically associated with abnormalities in brain development such as depression and Alzheimer’s disease. Once again the preclinical findings revealing that vitamin D can regulate catecholamine levels and protect against specific Alzheimer-like pathology increase the plausibility of this link..."
2. Vitamin D Supplementation Improves Cardiovascular Response to Head Up Tilt in Adolescents Suffering from Syncope - https://www.ahajournals.org/doi/10.1161/hyp.72.suppl_1.P396 - "...Compared to baseline, vitamin D supplementation reduced the HR elevation post HUT and reduced NE/Epi baseline levels..."
3. Effects of bioflavonoids on catecholamine biosynthetic activity in the adrenal gland: In vitro studies using partially purified tyrosine hydroxylase and chromaffin cell cultures - https://pubmed.ncbi.nlm.nih.gov/20504598/ - "...The findings presented here suggest that quercetin may inhibit catecholamine biosynthesis..."
4. Zinc controls cell pores to regulate storage and release of catecholamine - https://cen.acs.org/articles/95/i13/Zinc-controls-cell-pores-regulate.html - "...They found that cultured adrenal cells treated with zinc store less catecholamine than untreated cells. Even though the treated cells store less, they actually release the same amount of catecholamine as the untreated cells because they’re releasing nearly all of what they have taken in. That release also occurs much more slowly than the release from untreated cells..."
5. Vitamin C prevents stress-induced damage on the heart caused by the death of cardiomyocytes, through down-regulation of the excessive production of catecholamine, TNF-α, and ROS production in Gulo(−/−)Vit C-Insufficient mice - https://www.sciencedirect.com/science/article/abs/pii/S0891584913003675
6. Curcumin suppresses gelatinase B mediated norepinephrine induced stress in H9c2 cardiomyocytes - https://pubmed.ncbi.nlm.nih.gov/24116115/
7. Neuromodulatory effect of curcumin on catecholamine systems and inflammatory cytokines in ovariectomized female rats - https://pubmed.ncbi.nlm.nih.gov/33098686/
8. (–)-Epigallocatechin-3-O-gallate (EGCG) attenuates the hemodynamics stimulated by caffeine through decrease of catecholamines release - https://link.springer.com/article/10.1007/s12272-016-0757-1
9. Melatonin regulates catecholamine biosynthesis by modulating bone morphogenetic protein and glucocorticoid actions - https://www.sciencedirect.com/science/article/abs/pii/S0960076016301728
10. Sympathetic Activity Increases With Obesity in Hypertensive Patients - https://www.ahajournals.org/doi/10.1161/hyp.70.suppl_1.114 - "...Increase in BMI is associated with increasing dopamine, catecholamines and metanephrines indicative of progressive SANS activation..."
Magnesium salts seem to reduce catecholamine induced arythmia according to this
https://pubmed.ncbi.nlm.nih.gov/1665982/
And most people are Magnesium deficient
Thank you Walter. Melatonin has been on my radar for a while now. Even coffee is a source via phytomelatonin, certainly elevates it's importance for further study.
I take it as part of the FLCCC protocol whenever I've been exposed to someone who's got COVID or been recently jabbed. So far, so good. It doesn't help me sleep, though.
Walter... This makes a lot of sense to me. Melatonin has strong anti-inflammatory effects. Your research posts have really triggered me... Though I am an Ophthalmologist (cataracts, etc., x40 years), I veered into cannabis medicine in 2012 and have now seen thousands of patients in two states. Cannabidiol (CBD) and other variants (CBN, CBG, THC, etc.) will work similarly , I think. I did a quick search and found many papers on this topic, but need your research skills to flesh it out! I encourage all of my patients to take quality CBD as a supplement - anti-inflammatory, neuro-protective, anti-cancer, anti-Alzheiner's, helps regulate endocrine function and mood. In the US, CBD products with less that 0.3% THC are unregulated and legal in all 50 states, so can be ordered online. The biggest problem is the lack of regulation - half the CBD in the market is probably bogus. Add this to your research pile to sort through for dealing with catecholamines.
Part of the Plandemic plan, IMO, is to promote high levels of fear and anxiety through the population as this not only enhances compliance, but effectiveness of the bioweapon. Nothing drives a herd more than FEAR. PORN. 24/7/365!
Paper example: https://pubmed.ncbi.nlm.nih.gov/7391971/
Big Pharma? Big (dark) Chocolate! (lol)
Metabolic Effects of Dark Chocolate Consumption on Energy, Gut Microbiota, and Stress-Related Metabolism in Free-Living Subjects - https://pubs.acs.org/doi/abs/10.1021/pr900607v - "...Dark chocolate reduced the urinary excretion of the stress hormone cortisol and catecholamines and partially normalized stress-related differences in energy metabolism..."
Dark Chocolate Takes Bite Out of Stress - https://www.webmd.com/balance/stress-management/news/20091113/dark-chocolate-takes-bite-out-of-stress - ("...conducted by researchers at the Nestle Research Center...")
Heart Health Benefits of Dark Chocolate - https://intermountainhealthcare.org/blogs/topics/heart/2015/02/heart-health-benefits-of-dark-chocolate/ - "...Dark chocolate has been shown to reduce the levels of cortisol and epinephrine..."
Effects of dark chocolate consumption on the prothrombotic response to acute psychosocial stress in healthy men - https://www.thieme-connect.com/products/ejournals/abstract/10.1160/th14-05-0450 - "...our findings indicate that a single consumption of flavonoid- rich dark chocolate blunted the acute prothrombotic response to psychosocial stress, thereby perhaps mitigating the risk of acute coronary syndromes triggered by emotional stress..."
7 Foods That Are High in Magnesium (via Cleveland Clinic) - https://health.clevelandclinic.org/foods-that-are-high-in-magnesium/ - "Dark chocolate (70-85% cocoa): 1 oz. = 64 milligrams of magnesium (16% RDA)"
Another excellent, informative and highly informed post from Walter. My ex was an airline Captain flying long haul - he took it every day and swore by its abilities to assist with “time zone changes and their effects upon his mind and body” l have not so far tried it .. am on many other supplements, l often wonder what the effects are of taking them all together too - does one affect another, such as in “pharma” making it less stable or giving side effects? Anyway, off to buy some Melatonin Walter and again a huge thank you for your much anticipated and appreciated articles! Substack wouldn’t be the same without you! Wishing you a good weekend!
Terrific!
Doris Loh is an esteemed, really prominent ascorbic acid and melatonin researcher. I just posted your article on her Facebook page!
https://www.facebook.com/groups/1406779789714470
Then you can deal with the topic of light next Friday. Take a closer look at the Nobel Prize for Chemistry 2015 and the Nobel Prize for Medicine 2009. There is a mistake in the one for medicine. Find it
It's a pity that melatonin in Canada and Australia is considered a medicine and not a dietary supplement as in the USA. Dr. prescription required for compounding chemist/pharmacist.
I love this post! Melatonin feels good for me. I have problems with GABA, though.
Hi and thank you for responding. It was a “mix” of supplements that my naturopath suggested to me .. However, l have had my own concerns about this and believe you may be right. I know that K2 is important, so what would you suggest? I am grateful for any suggestions you may have. I am dealing (or attempting to deal with) Multiple Chemical Sensitivities, Multiple Food Allergies, EMR Sensitivities and have Mast Cell Activation Syndrome. Life is quite “challenging” but l do try to keep my somewhat crazy sense of humour .. most days! I was doused in Glyphosates about 10 years ago whilst out walking my dogs in a low country lane. A farmer was spraying his fields and gave little thought to the possibility that someone may be walking along the lane - so swing arm of spraying machine came over my head - killed one of my dogs outright and almost me .. following several weeks in hospital and goodnsss only knows what they pumped into me .. l came home to find that slowly l became more and more allergic to … everything .. it is a “hot political topic” as so many people, the current estimate being 1 in 3, are developing auto immune conditions. I was not vax’d and will not take the flu Vax either as “they” are in the process of combining the two as you may know .. So .. my GP will only give me the 1000yd stare when l endeavour to “open up the conversation” on G and allergies .. which is why l sought a Naturopath. There are only 3 Consultant’s working in Britain who are prepared to work with these conditions - they are private but there is a two year wait. Thank you again for drawing this to my attention - any suggestions are gratefully received.
Can you further enlighten me? I am am interested in the effects of taking supplements and their effects upon each other - l take Quercetin, Vit D3, Glutathione, Zinc, Iodine, Activated Charcoal with Vit K2, Vitamin B12, low dose Aspirin and Zeolite .. your thoughts, after picking yourself up from the carpet?