Friday Hope: Melatonin Supresses Catecholamine Synthesis

Melatonin may be an effective therapeutic in reducing SPED and COVID catecholamine storms.

I would like to bring to everyone’s attention a very good paper which demonstrates how Melatonin reduces the synthesis of catecholamines. As endothelial cells are able to synthesize catecholamines, Melatonin may prove to be an effective therapeutic in supressing the observed catecholamine storms in COVID and SPED.

Melatonin treatment significantly reduced the mRNA expression of catecholamine synthases, including the rate-limiting enzyme tyrosine hydroxylase (Th), 3,4-dihydroxyphenylalanine decarboxylase and dopamine-β-hydroxylase expressed in PC12 cells.

Melatonin regulates catecholamine biosynthesis by modulating bone morphogenetic protein and glucocorticoid actions
https://www.sciencedirect.com/science/article/abs/pii/S0960076016301728#