I take ACE inhibitors for hypertension. Is this likely to enhance my chances of a favourable outcome if I become infected with the spike protein? I have not had any Covid "vaccinations".
I take ACE inhibitors for hypertension. Is this likely to enhance my chances of a favourable outcome if I become infected with the spike protein? I have not had any Covid "vaccinations".
Michael, from the abstract of the paper by Ouk et al. (2021) linked by Walter: "ARB use was associated with greater preservation of memory and attention/psychomotor processing speed, particularly compared to ACE-Is that do not cross the blood-brain- barrier." ARB is the ACE2 receptor blocker and ACE-I is the ACE2 enzyme inhibitor. I was forced to take ARB (Losartin potassium, 50 mg/day) for about 15 years as my BP was 225/125. From what I could learn then, ARBs are preferable to ACE-Is. Amazingly, my BP is now 130/80 so I stopped. I was taking Losartin when I had quite severe Covid in August 2020. I wondered the same thing at the time. To my knowledge nobody has studied the effect of ARBs on Covid infection, but my experience shows that you may get severely ill from the viral infection while on an ARB. If only I had Ivermectin at the time I would have been cleared in a day or two, and would not be suffering the long-term consequences that I am dealing with at present. Of course, if Ivermectin had been readily available in 2020 then there would have been no pandemic, which was the reason for restricting it.
How would that pair with the articles on cerebral vascular function and physical endurance? They seem to be saying that a deficiency of ACE2 is negative so would that not mean an inhibitor is the same as being deficient?
I donтАЩt think weтАЩre anywhere near an answer to this. Ace inhibitors and blockers probably result in an up regulation of ACE-2 receptors so this is not an easy question to answer.
Yes... because there were studies some yrs ago (can you believe we've been in this for yrs??? I'm afraid I'll be dead before this nonsense is over!)... and they seemed to observe that those on ACE2 inhibitors were faring much better.
I take ACE inhibitors for hypertension. Is this likely to enhance my chances of a favourable outcome if I become infected with the spike protein? I have not had any Covid "vaccinations".
Michael, from the abstract of the paper by Ouk et al. (2021) linked by Walter: "ARB use was associated with greater preservation of memory and attention/psychomotor processing speed, particularly compared to ACE-Is that do not cross the blood-brain- barrier." ARB is the ACE2 receptor blocker and ACE-I is the ACE2 enzyme inhibitor. I was forced to take ARB (Losartin potassium, 50 mg/day) for about 15 years as my BP was 225/125. From what I could learn then, ARBs are preferable to ACE-Is. Amazingly, my BP is now 130/80 so I stopped. I was taking Losartin when I had quite severe Covid in August 2020. I wondered the same thing at the time. To my knowledge nobody has studied the effect of ARBs on Covid infection, but my experience shows that you may get severely ill from the viral infection while on an ARB. If only I had Ivermectin at the time I would have been cleared in a day or two, and would not be suffering the long-term consequences that I am dealing with at present. Of course, if Ivermectin had been readily available in 2020 then there would have been no pandemic, which was the reason for restricting it.
How would that pair with the articles on cerebral vascular function and physical endurance? They seem to be saying that a deficiency of ACE2 is negative so would that not mean an inhibitor is the same as being deficient?
Good point. Hopefully, somebody with expertise in this field will be able to provide some clarification.
I donтАЩt think weтАЩre anywhere near an answer to this. Ace inhibitors and blockers probably result in an up regulation of ACE-2 receptors so this is not an easy question to answer.
Yes... because there were studies some yrs ago (can you believe we've been in this for yrs??? I'm afraid I'll be dead before this nonsense is over!)... and they seemed to observe that those on ACE2 inhibitors were faring much better.
I wondered this in the very early days of COVID. IтАЩd like to hear from Walter on this.