One study references the use of chlorpheniramine nasal spray "under developement" for use as a nasal spray. The source of the spray in the study referenced in this WMC Research substack was not readily available from my skim of the study but if asked the author may well tell you.
As with easy to make antiviral oral and nasal sprays such as 12% xylitol in plain filtered boiled sterile water or 0.5% or 1% povidone-iodine in alkalized normal or higher saline and antiviral flush/wash for oral/nasal/eye use such as 1% regular Johnson's baby shampoo in alkalized normal "NeilMed" formula saline, - perhaps 'intranasal chlorpheniramine' could be made at home. (as can hydroxychloroquine in saline for nebulization - near instant high active levels where needed with very little systemic absorption thus no side effects.)
From Wickedpedia, the free encyclopedia (chlorpheniramine) Solubility in water 0.55 g/100 mL, liquid mg/mL (20 °C) and from a quick look around the chlorpheniramine pills contain 4 mg of chlorpheniramine
both 0.4% iCPM solution and 1% iCPM solution was used in the referenced study "Mitigating the risks of post-acute sequelae of SARS-CoV-2 infection (PASC) with intranasal chlorpheniramine: perspectives from the ACCROS studies" 0.4% and 0.5% seem to be commonly researched with no problems noted.
for figuring purposes 1 mg or 1/4 pill with, if coated, the coating rubbed/washed off first = 0.5% of what? weight of saline to add it to to get a ~0.5% solution? Looks like 200 mg of saline to me then filtered or syringe sterile filtered and put in a a metered spray pump type nasal spray bottle such as the "Snout" brand I purchased at Amazon in mid 2020 and which have worked very well. But somehow putting 1 pill i.e. 4mg of chlorpheniramine into 800 mg of water seems ? like less than 1 gram of water is very little water ??? best to ask or find a study where the preparation of the spray is spelled out in the study or supplimentary data
available over the counter Astepro azelastine nasal spray is also useful as a antiviral antihistamine for sars-cov2 and other virus.
There was broad use of Antihistamines in treatment protocols for covid from the beginning.
"Antihistamines and azithromycin as a treatment for COVID-19 on primary health care – A retrospective observational study in elderly patients" showed a reduction of an average of a 28% death rate in nursing homes in Spain to "0" early in 2020. from my note to the author "I read in your study that you used dexchlorpheniramine, cetirizine or loratadine and specifically that you used dexchlorpheniramine as the antihistamine of choice, at that time, in the treatment protocol for your most severe cases."
Dr. Shankara Chetty also used a first generation antihistamine drug with anticholinergic and sedative actions to treat his patients in the severe allergic/inflammatory clumping/microclotting loe blood oxygen stage of covid-19. His drug choice has been to first use promethazine for its effect and then switch to a levocetirizine and montelukast
Dr Chetty used type 1 antihistamines ( promethazine) also, as the first drug to treat people who seemingly recovered from covid then rapidly deteriorated starting around the 8th day from the start of symptoms and used the amount increase in oxygen concentration within 2 to 4 hours as a marker to determine starting dose of steroids then he increased steroids rapidly as needed until restoration of oxygen concentration began. When the second wave in S. Africa showed more gastrointestinal symptoms he added type 2 antihistamines "your cimetidine and famotidine"
Dr Darrel DeMello included cetirizine
Dr. Richard Urso included cyproheptadine in his covid treatment
3) https://www.youtube.com/watch?v=Wetdq9vX__c "Dr. Farid Jalali Discusses COVID Management" deep platelet / serotonin science here, he further explains the reasons for clotting and use of treatments adding fluvoxamine if started day one and the use of the antihistamine cyproheptadine if starting in the severe later stage covid.
From "Treatment of the Serotonin Syndrome with Cyproheptadine" "She then was given 4 mg of cyproheptadine orally. Within 30 minutes her symptoms subsided. About 1 hour later the symptoms began to worsen again; she was given a second 4-mg dose, and within 30 minutes her symptoms had resolved completely. Three hours after receiving the initial dose of cyproheptadine, urinary retention developed, which resolved three hours later. The patient's movement and urinary symptoms did not recur, and no new symptoms developed.
Azelastine inhibits viropexis of SARS-CoV-2 spike pseudovirus by binding to SARS-CoV-2 entry receptor ACE2
Given that the olfactory pathway provides such an effective conduit for entry of the Spike into the body (and the attendant H1 affinity, etc) is it reasonable to consider/propose this to be a principle means by which many lost their sense of smell and it's delayed return as a key sensory function?
Trying to digest this.... I'm still wondering why over time the body doesn't degrade the spike no matter where it is located. The unvaxxed shouldn't be seeing a continual burden of spike, should they?
Any idea why systemic (oral) wouldn't work like an intranasal? I may have to experiment on myself and see what happens but pills always have additives I may not want.
If the spike is continually being produced in the body due to the alleged mRNA instructions that turn cells into little spike factories (if that is in fact true, not everyone buys into that idea) then the supply of circulating spike is continually being replenished so there is that aspect? A smart combination of supplements is, imho, the best strategy for mitigating things. And as such they do not contain a host of potentially harmful additives or concerning substances. I agree we have to be willing to be a living experiment and monitor our function and adjust accordingly.
That ought essentially to be correct, I believe so anyway. The biggest nagging issue in my mind, however, is if an unvaxxed individual had intimate contact with someone who had been jabbed (whether knowingly or not), especially one who had taken two or more injections. Not speaking of the general notion re "shedding" (far less likely) here but of the exchange of bodily fluids which might introduce the replication/production phenomenon into the system of the unjabbed partner. In any event someone who rolled up their sleeve is far more likely to become a manufacturing operation, as far as I know? (or think I do :o)
Please, can you tell me where Chlorpheniramine can be obtained ... and the dosage? This could be huge for me! I received Pfizer EN6200 & ER8734 (among the Most Toxic batches). Initially, the consequences were devastating. Now, I take a full regiment, using your recommendations and those from Peter McC, AFLD, etc. It has dramatically slowed, inhibited, neutralized ... the SPIKE Damage. However, I have significant eye issues, horrible sinus issues, the worse headaches ever, etc ... and I believe they are all Neurological in origin. BLESS YOU SIR!
Fascinating. Thank you for your hard work 💜!
How does one obtain 'intranasal chlorpheniramine'? Is it available in any over the counter nasal treatment?
Peter A. McCullough, MD, MPH interview with Dr. Gustavo Ferrer, FCCP - ClorRelief Nasal Spray inventor
ClorRelief Nasal Spray with Chlorpheniramine said by inventor to be available OTC in the US in January 33:33 and at 34:29 into the video here https://petermcculloughmd.substack.com/p/prevention-and-treatment-of-the-common?utm_source=podcast-email&publication_id=1119676&post_id=152364240&utm_campaign=email-play-on-substack&utm_content=watch_now_button&r=xjgqk&triedRedirect=true&utm_medium=email
One study references the use of chlorpheniramine nasal spray "under developement" for use as a nasal spray. The source of the spray in the study referenced in this WMC Research substack was not readily available from my skim of the study but if asked the author may well tell you.
As with easy to make antiviral oral and nasal sprays such as 12% xylitol in plain filtered boiled sterile water or 0.5% or 1% povidone-iodine in alkalized normal or higher saline and antiviral flush/wash for oral/nasal/eye use such as 1% regular Johnson's baby shampoo in alkalized normal "NeilMed" formula saline, - perhaps 'intranasal chlorpheniramine' could be made at home. (as can hydroxychloroquine in saline for nebulization - near instant high active levels where needed with very little systemic absorption thus no side effects.)
From Wickedpedia, the free encyclopedia (chlorpheniramine) Solubility in water 0.55 g/100 mL, liquid mg/mL (20 °C) and from a quick look around the chlorpheniramine pills contain 4 mg of chlorpheniramine
both 0.4% iCPM solution and 1% iCPM solution was used in the referenced study "Mitigating the risks of post-acute sequelae of SARS-CoV-2 infection (PASC) with intranasal chlorpheniramine: perspectives from the ACCROS studies" 0.4% and 0.5% seem to be commonly researched with no problems noted.
for figuring purposes 1 mg or 1/4 pill with, if coated, the coating rubbed/washed off first = 0.5% of what? weight of saline to add it to to get a ~0.5% solution? Looks like 200 mg of saline to me then filtered or syringe sterile filtered and put in a a metered spray pump type nasal spray bottle such as the "Snout" brand I purchased at Amazon in mid 2020 and which have worked very well. But somehow putting 1 pill i.e. 4mg of chlorpheniramine into 800 mg of water seems ? like less than 1 gram of water is very little water ??? best to ask or find a study where the preparation of the spray is spelled out in the study or supplimentary data
available over the counter Astepro azelastine nasal spray is also useful as a antiviral antihistamine for sars-cov2 and other virus.
There was broad use of Antihistamines in treatment protocols for covid from the beginning.
"Antihistamines and azithromycin as a treatment for COVID-19 on primary health care – A retrospective observational study in elderly patients" showed a reduction of an average of a 28% death rate in nursing homes in Spain to "0" early in 2020. from my note to the author "I read in your study that you used dexchlorpheniramine, cetirizine or loratadine and specifically that you used dexchlorpheniramine as the antihistamine of choice, at that time, in the treatment protocol for your most severe cases."
Dr. Shankara Chetty also used a first generation antihistamine drug with anticholinergic and sedative actions to treat his patients in the severe allergic/inflammatory clumping/microclotting loe blood oxygen stage of covid-19. His drug choice has been to first use promethazine for its effect and then switch to a levocetirizine and montelukast
Dr Chetty used type 1 antihistamines ( promethazine) also, as the first drug to treat people who seemingly recovered from covid then rapidly deteriorated starting around the 8th day from the start of symptoms and used the amount increase in oxygen concentration within 2 to 4 hours as a marker to determine starting dose of steroids then he increased steroids rapidly as needed until restoration of oxygen concentration began. When the second wave in S. Africa showed more gastrointestinal symptoms he added type 2 antihistamines "your cimetidine and famotidine"
Dr Darrel DeMello included cetirizine
Dr. Richard Urso included cyproheptadine in his covid treatment
3) https://www.youtube.com/watch?v=Wetdq9vX__c "Dr. Farid Jalali Discusses COVID Management" deep platelet / serotonin science here, he further explains the reasons for clotting and use of treatments adding fluvoxamine if started day one and the use of the antihistamine cyproheptadine if starting in the severe later stage covid.
From "Treatment of the Serotonin Syndrome with Cyproheptadine" "She then was given 4 mg of cyproheptadine orally. Within 30 minutes her symptoms subsided. About 1 hour later the symptoms began to worsen again; she was given a second 4-mg dose, and within 30 minutes her symptoms had resolved completely. Three hours after receiving the initial dose of cyproheptadine, urinary retention developed, which resolved three hours later. The patient's movement and urinary symptoms did not recur, and no new symptoms developed.
Azelastine inhibits viropexis of SARS-CoV-2 spike pseudovirus by binding to SARS-CoV-2 entry receptor ACE2
"Repurposing potential of 1st generation H1-specific antihistamines as anti-filovirus therapeutics" https://pubmed.ncbi.nlm.nih.gov/29981374/
and on and on
I see that Amazon has a chlorpheniramine throat spray. Could it be sprayed into the nose effectively (and safely)? If I get Covid again, I may try it.
"This research was funded by Dr. Ferrer Biopharma."
enough said
Simply brilliant work Walter, many thanks.
Meanwhile, the House of Representatives just released a report praising the results of the C-19 Vax. What a dystopian twilight zone!
And thank you, Walter (Soldier)!
Given that the olfactory pathway provides such an effective conduit for entry of the Spike into the body (and the attendant H1 affinity, etc) is it reasonable to consider/propose this to be a principle means by which many lost their sense of smell and it's delayed return as a key sensory function?
Trying to digest this.... I'm still wondering why over time the body doesn't degrade the spike no matter where it is located. The unvaxxed shouldn't be seeing a continual burden of spike, should they?
Any idea why systemic (oral) wouldn't work like an intranasal? I may have to experiment on myself and see what happens but pills always have additives I may not want.
If the spike is continually being produced in the body due to the alleged mRNA instructions that turn cells into little spike factories (if that is in fact true, not everyone buys into that idea) then the supply of circulating spike is continually being replenished so there is that aspect? A smart combination of supplements is, imho, the best strategy for mitigating things. And as such they do not contain a host of potentially harmful additives or concerning substances. I agree we have to be willing to be a living experiment and monitor our function and adjust accordingly.
But if you’re unvaxxed there shouldn’t be factories…. no?
That ought essentially to be correct, I believe so anyway. The biggest nagging issue in my mind, however, is if an unvaxxed individual had intimate contact with someone who had been jabbed (whether knowingly or not), especially one who had taken two or more injections. Not speaking of the general notion re "shedding" (far less likely) here but of the exchange of bodily fluids which might introduce the replication/production phenomenon into the system of the unjabbed partner. In any event someone who rolled up their sleeve is far more likely to become a manufacturing operation, as far as I know? (or think I do :o)
Thank you.
Please, can you tell me where Chlorpheniramine can be obtained ... and the dosage? This could be huge for me! I received Pfizer EN6200 & ER8734 (among the Most Toxic batches). Initially, the consequences were devastating. Now, I take a full regiment, using your recommendations and those from Peter McC, AFLD, etc. It has dramatically slowed, inhibited, neutralized ... the SPIKE Damage. However, I have significant eye issues, horrible sinus issues, the worse headaches ever, etc ... and I believe they are all Neurological in origin. BLESS YOU SIR!