The Spike Protein Binds to CD4 T Cells: Impairment and Possible Depletion

This is almost certainly a key factor in the surge of turbo cancers.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects CD4+ T cells in vitro and in vivo. 

Peripheral blood CD3+CD4+ and CD3+CD8+ were exposed to mock control or SARS-CoV-2 (CoV-2) (Multiplicity of Infection (MOI) = 1) for 1 hr under continuous agitation. (A) Viral load was assessed by RT-qPCR 24 hr after infection. (B) Cells were washed, cultured for 24 hr, fixed with 4% paraformaldehyde (PFA), and stained with the RdRp probe for in situ hybridization or anti-sCoV-2 for immunofluorescence. Cells were analyzed by confocal microscopy. (C, C1–C5) Representative transmission electron microscopy (EM) micrographs showing viral particles (asterisks) inside lymphocytes 2 hr after infection. (D) Viral load was determined by qPCR 2 hr, 6 hr, 12 hr, 24 hr, and 48 hr after infection. (E) Vero cells were incubated with the supernatant of mock control or CoV-2-infected CD4+T cells under continuous agitation for 1 hr. The viral load in Vero cells was measured after 72 hr using plaque assay. PFU, plaque-forming unit. (F) Viral load was measured by RT-qPCR in peripheral blood CD4+ and CD8+ T cells from healthy controls (HC) and COVID-19 patients. (G) CoV-2 RNA detection in CD4+ T cells from bronchoalveolar lavage fluid (BALF) single-cell RNA sequencing data revealing the presence of CoV-2 RNA. Data represents mean ± SEM of at least two independent experiments performed in triplicate or duplicate (f). ***p<0.001; ND, not detected. 

It has now become an all too familiar trope: The prevalence of turbo cancers has increased dramatically, yet doctors are at a loss to explain. I believe the explanation is right in front of us. The Spike Protein of SARS-CoV-2 binds to CD4 (JUST LIKE HIV!) and impairs their function – possibly even destroying them.  

Here, we show that SARS-CoV-2 infects human CD4+ T helper cells, but not CD8+ T cells, and is present in blood and bronchoalveolar lavage T helper cells of severe COVID-19 patients. We demonstrated that SARS-CoV-2 spike glycoprotein (S) directly binds to the CD4 molecule, which in turn mediates the entry of SARS- CoV-2 in T helper cells. This leads to impaired CD4 T cell function and may cause cell death. 

SARS-CoV-2 uses CD4 to infect T helper lymphocytes 
https://elifesciences.org/articles/84790#content 

Why is this important? Because CD4 cells are CRITICAL for surveilling the body and rooting out cancer cells for destruction. If cancer establishes itself, CD4 cells assist in antitumoral immunity. 

CD4+ T cells play a critical role in cancer surveillance. In addition to their classical helper function in assisting CD8+ T-cell priming in lymph nodes 1, 2, CD4+ T cells mediate antitumoral immunity from within the tumour microenvironment (TME). In murine models, CD4+ T cells promote antitumoral immunity within the TME by recruiting and activating other immune effectors, such as CD8+ T cells, macrophages and natural killer (NK) cells, or by directly acting on stromal cells (reviewed in [3]). In addition, cancer-specific CD4+ T cells can express cytotoxic programmes, similar to those reported for CD8+ T cells, and have been shown to lyse cancer cells in vitro 4, 5. Clinical data, albeit limited, support a direct antitumoral role of CD4+ T cells. 

The multifaceted roles of CD4+ T cells and MHC class II in cancer surveillance 
https://www.sciencedirect.com/science/article/abs/pii/S095279152300064X 

It is not a difficult mental exercise to understand the significance of this. Indeed, I am bewildered that doctors haven’t been shouting this observation from the rooftops: If you impair and/or deplete CD4 T Cells, you are taking away a major cancer gatekeeper. And it depends on what stage your body is dealing with cancer. If you are prone, it may be more likely to establish itself. If malignancy is new, it may vehemently accelerate its progress. If you are in remission – it may prevent your body from KEEPING IT IN REMISSION! 

Yet another reason why the Spike Protein must be avoided at all costs. I will continue to seek understanding and solutions. 

I hope all enjoyed a pleasant (yet sweltering, here in VT) weekend.