WMC Research

Share this post

SEVERE COVID AND LONG COVID AS RAPID AND INDOLENT VARIANTS OF SYSTEMIC FIBRINOGEN AMYLOIDOSIS

wmcresearch.substack.com

SEVERE COVID AND LONG COVID AS RAPID AND INDOLENT VARIANTS OF SYSTEMIC FIBRINOGEN AMYLOIDOSIS

Infection/transfection with Spike Protein of SARS-CoV-2 replaces liver as amyloid source

Walter M Chesnut
Jun 2, 2022
90
52
Share this post

SEVERE COVID AND LONG COVID AS RAPID AND INDOLENT VARIANTS OF SYSTEMIC FIBRINOGEN AMYLOIDOSIS

wmcresearch.substack.com

Refining previously discussed pathogenic mechanisms of SARS-CoV-2.

In 2010 a very important article was published in the journal Blood:

Fibrinogen amyloidosis: the clot thickens!

The article states that:

Fibrinogen amyloidosis (AFib), discovered more than 15 years ago, is amyloid deposition occurring due to the presence of a variant of fibrinogen, which is produced exclusively by the liver.

It also reveals that:

They conclude that AFib is not solely nephropathic, but is a more systemic disease with a diverse and complex phenotype… Stangou et al suggest that direct amyloid deposition in vascular walls may be the first step in a disease process that leads to IMPARIED ENDOTHELIAL FUNCTION, and that nephrotic syndrome with hyperlipidemia and hypertension may then facilitate atheroma formation.

https://ashpublications.org/blood/article/115/15/2985/26865/Fibrinogen-amyloidosis-the-clot-thickens

What is important here is that whereas the liver creates an aberrant, misfolded, undegraded amyloid fibril producing protein which is deposited in Fibrinogen Amyloidosis, THE EXACT SAME EFFECT IS GENERATED BY THE SPIKE PROTEIN OF SARS-CoV-2 DUE TO ITS INTERACTION WITH NEUTROPHIL ELASTASE.

As professor Per Hammarstrom discovered:

When the spike protein is cut up, it produces the exact piece of protein which, according to the researchers’ analysis, is most likely to produce amyloid. This enzyme is released in large quantities from one type of white blood cells, neutrophils, which are released early on during infections such as COVID-19. When the researchers mixed pure spike protein with this enzyme, called neutrophil elastase, unusual fibrils were produced.

We have never seen such perfect, but scary, fibrils as these ones from the amyloid-producing SARS-CoV-2 spike protein and pieces thereof. The fibrils starting from the full-sized spike protein branched out like limbs on a body. Amyloids don’t usually branch out like that. We believe that it is due to the characteristics of the spike protein.

It is due to this property that it perfectly mimics Fibrinogen Amyloidosis. In the words of Sofie Nystrom: “Our experiment shows that if fibrin is formed in the presence of spike amyloid, the plasmin can not totally remove the fibrin clots.” And there you have the exact same effect as the misfolded fibrinogen protein in Fibrinogen Amyloidosis.

Is the combination of Fibrinogen, the Spike Protein of SARS-CoV-2 and Neutrophil Elastase the basis for the pathology of Severe COVID and Long COVID?

https://liu.se/en/news-item/mojlig-mekanism-bakom-gatfulla-symtom-vid-covid-19-upptackt

https://www.medicalnewstoday.com/articles/misfolded-spike-protein-could-explain-complicated-covid-19-symptoms#SARS-CoV-2-and-fibrils

52
Share this post

SEVERE COVID AND LONG COVID AS RAPID AND INDOLENT VARIANTS OF SYSTEMIC FIBRINOGEN AMYLOIDOSIS

wmcresearch.substack.com
52 Comments
Dr Ah Kahn Syed
Writes Arkmedic's blog
Jun 3, 2022Liked by Walter M Chesnut

I don't think it affects covid infection but would really account for the clots seen in the vaccinated, who produce spike much longer and at much higher levels - depending on the rate of production from the mRNA signal which has a huge biological variability.

Expand full comment
Reply
2 replies
Skyhawk999
Jun 4, 2022Liked by Walter M Chesnut

Had to post this straight away. Wife's friend works in a neuro depot UK. Not awake. Chatting in general, I mentioned about amyloidosis, her reply, we are seeing a huge increase in cases

You are spot on Sir Walter

Expand full comment
Reply
2 replies by Walter M Chesnut and others
50 more comments…
TopNewCommunity

No posts

Ready for more?

© 2023 Walter M Chesnut
Privacy ∙ Terms ∙ Collection notice
Start WritingGet the app
Substack is the home for great writing