I'm no medical expert, but have been suspecting that the harms from catching Covid and from injecting spike proteins (and the whole lot in the "vaccines") speeds up the aging process. Sadly, as time goes by, I'm convinced it is the case, and I take it that your view is the same. Would you please elaborate a bit more on the MCC950? Thanks.

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Mr Chestnut I just found your Substack a few days ago and have learned so much. You see, I have been suffering from “Long Covid” for 18 long months. I am absolutely certain I suffer from Cachexia (65 lb unintentional weight loss in 18 months) after having Covid in Dec 2020. My primary care physicians can’t find anything unusual and MRI and CT Scan didn’t show anything alarming. Bloodwork seems decent as well. I don’t know who to turn to. The doctors just seem oblivious to the effects of Long Covid. I don’t know what type of specialist I should go see. Do you have any idea what kind of physician (specialist) I should seek help from? I’m down to 116 lbs now and feel I am literally wasting away. I can’t add any weight and I am very confused and frightened. Thank you kindly for any suggestions. God Bless you and your research on this debilitating condition.

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Any chance "MCC950" has a food source?

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There has been a lot of discussion in the weirder parts of the web regarding Nicotinic Acid and Melatonin for COVID19 long haul treatment. One the main proponent's being the very peculiar Dr. Dmitry Kats.

Still, not wishing to dismiss the message because of the messenger, every article I read of Walters leads me to check against Niacin and Melatonin.

Here again I find that Nicotinic acid inhibits NLRP3 inflammasome activation via SIRT1 in vascular endothelial cells (Vitamin B3 flush), and Melatonin also inhibits NLRP3 activity.

If I was going to slow kill a few billion people with a virus that I and my family were going to catch, I would want the cure to be very simple with a supply that could be stored for the long term. But whatever the truth of it, Niacin and Melatonin require serious consideration.

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Walter, you were born for such a time as this. Your stacks read like mystery novellas (which have half the words are in a foreign language). There is Google translate for Portuguese...there needs to be one for Walterese.

It’s all good. I am learning!

You research constantly. Did you see my comment with links so you can have professional librarians (all have at least a masters) search world class resources for you for free? You obviously have mastered the search engine but a little help never hurts. Also, they have paid the fees so they can access every journal.

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Jul 3, 2022·edited Jul 3, 2022

Beta-hydroxy butyrate is an NLP3 inflammasome inhibitor. Butyrate is produced by gut microbes in response to intermittent fasting and prebiotic fibre

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You’re an amazing human being Walter 🙏

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Quickly found these potential NLRP3 activation inhibitors, other than the MCC950 research salt:

0) ginger (more specifically it's phytochemicals, esp. 6-shogaol)


1) Quercetin


2) Omega-3 fatty acids (fish oil, esp. DHA)




3) DHEA (NB! "DHEA induces abnormal autophagy and exacerbates pyroptosis in Nig-treated inflammatory macrophages via GPER activation.")



4) Chlorella


5) Ursolic Acid (from Rosemary leaves)


6) Curcumin


7) Resveratrol (in conjunction with Omega-3 Fatty acids)


8) Vitamin B2 (riboflavin)


9) Vinpocetine


10) Procyanidin B2 (specific apple extract)


11) Methylsulfonylmethane (MSM)


12) Sulforaphane (broccoli sprouts, seeds, as a supplement)


13) Astaxanthin


14) Melatonin


15) Silybin (from Milk Thistle)


16) Olive leaf extract


17) Raspberry polyphenols


18) Fucoidan


19) Luteolin


20) Nicotinamide riboside (NAD+)


21) Erianin (extract of Dendrobium chrysotoxum Lindl. )


22) Oridonin ( Rabdosia rubescens aka Donglingcao in TCM)


23) Fluoxetine (!)


24) Emodin ( from rhubarb, buckthorn, and Japanese knotweed)


25) Vitamin D3


26) Echinatin (extract from Dracaena draco, Glycyrrhiza echinata)


27) β-hydroxybutyrate (i.e. in BHB products, MCT oil, Caprylic Acid, or via a ketogenic diet)





Also, be careful with (i.e. consider NOT using)...

Statins (blood lipid lowering cholesterol medications)


"Statin activation of p38 upstream of IL-1β led to priming of this NLRP3 inflammasome effector in macrophages"

Caveat Emptor! This is just a quick list of HITS, not proven. FWIW.

This looks like a job for SIRT1-activators in general.

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Unadulterated adoration for all things/thoughts Walter

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Anti-NLRP3 Inflammasome Natural Compounds: An Update - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912743/

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IV arginine could downregulate NLRP3 inflammasome:


And maybe caffeine too:


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I guess...the elite did take a saline shot and booster afterall!!!!

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Love you but please explain this to me like I’m a child

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Walter - why not reduce the NLRP3- inflammasome and oxidative stress naturally with Vitamin D?


MCC950 has been looked at in mice for Covid - and on paper it looks promising - however, I would suggest caution because it acts by reducing DRP1 and therefore mitochondrial fission - this is an important quality control mechanism for the mitochondria and any dysregulation is likely to have adverse consequences eg pro-tumour effects, as well as beneficial effects.



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Found this article

Targeting the NLRP3 Inflammasome With Inhibitor MCC950 Prevents Aortic Aneurysms and Dissections in Mice

Lots of this happening lately. The Depeche Mode band member of the the most recent to die from it

Brilliant Walter

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This information is wonderful, and offers such hope! Apparently, MCC950 was previously also known as CRID3 sodium salt. I've found one place where it is available for sale, at rather exorbitant prices: https://www.tocris.com/products/crid3-sodium-salt_5479

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