MORE EVIDENCE PROVING MY EARLY HYPOTHESES CORRECT - HOW MANY LIVES COULD HAVE BEEN SAVED?
I Wish More People Would Listen to Me
Early on, I saw that β-hydroxybutyrate could be a strong therapeutic against COVID. Of course, my suggestion for trials went unheeded. At the highest levels.
And yesterday I was proven correct.
Here we report impaired production of BHB in humans with SARS-CoV-2-induced but not influenza-induced acute respiratory distress syndrome (ARDS). CD4+ T cell function is impaired in COVID-19 and BHB promotes both survival and production of Interferon-γ from CD4+ T cells. Using metabolic tracing analysis, we uncovered that BHB provides an alternative carbon source to fuel oxidative phosphorylation (OXPHOS) and the production of bioenergetic amino acids and glutathione, which is important for maintaining the redox balance. T cells from patients with SARS-CoV-2-induced ARDS were exhausted and skewed towards glycolysis, but can be metabolically reprogrammed by BHB to perform OXPHOS, thereby increasing their functionality.
Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19
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