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There are besides two more reasons, why the mitochondria suffer:
1. The N1-methyl-Ψ
2. "Enzymatically synthesized mRNA preparations contain double-stranded RNA (dsRNA) contaminants as aberrant products of the IVT reaction. […] Recognition of IVT mRNA contaminated with dsRNA results in robust type I interferon produc…
There are besides two more reasons, why the mitochondria suffer:
1. The N1-methyl-Ψ
https://drbine-substack-com.translate.goog/p/haben-wir-es-teilweise-vielleicht?_x_tr_sl=de&_x_tr_tl=en&_x_tr_hl=de&_x_tr_pto=wapp
2. "Enzymatically synthesized mRNA preparations contain double-stranded RNA (dsRNA) contaminants as aberrant products of the IVT reaction. […] Recognition of IVT mRNA contaminated with dsRNA results in robust type I interferon production, […] leading to the inhibition of translation and the degradation of cellular mRNA and ribosomal RNA, respectively."
https://drbine-substack-com.translate.goog/p/die-kurios-verquere-gedankenwelt?_x_tr_sl=de&_x_tr_tl=en&_x_tr_hl=de&_x_tr_pto=wapp
Pardi N, Hogan MJ, Porter FW, Weissman D. mRNA vaccines - a new era in vaccinology. Nat Rev Drug Discov. 2018 Apr;17(4):261-279. doi: 10.1038/nrd.2017.243. Epub 2018 Jan 12. PMID: 29326426; PMCID: PMC5906799. https://www.nature.com/articles/nrd.2017.243