I am going to be honest..this "Does repeated exposure to the Spike Protein, either via infection or vaccination induce and/or accelerate these processes?" is scary AF.
That concern rests entirely on the validity of this sentence:
"I reference again the Swedish paper above, to illustrate that not only is this mechanism how the Spike Protein induces Amyloidosis, but also how it PROPAGATES ITSELF WITHOUT THE PRESENCE OF THE VIRUS."
Without this, the spike is a toxin, nasty but something that can be dealt with in most cases via the body's detoxification systems. However if it can self-propagate then all bets are off.
I'm just not seeing it, extraordinary claims take extraordinary evidence as they say. It's an interesting theory but don't prions do their damage by inducing other (i.e. different) proteins to misfold? How can a spike protein create more spikes? I see how it can foul up other proteins (which is really bad of course) but how does it propagate itself?
Reminiscent of a theory of ME/CFS called "Hit-and-Run", where no virus is found, but chronic panoply of symptoms persist. Perhaps a similar scenario as in your theory Walter.
Are you talking Epstein Barr virus?? I’ve thought the whole time this was based on inciting EBV, the name alone, because this whole thing is a play on words. Most of this article is way above my understanding, but about 95% of all humans have Epstein Barr it would make sense that would be a target.
We have " Long.Covid assesment centre in Adelaide Australia. It seems to me they should be really reading Walter's articles and reaching out for collaboration. When I called an acquaintance who works there, i was told it is not how they operate.
Also, the University of Tasmania Dementia Reserach Centre. There are so many "research " pockets around the world looking at amyloid but no effective treatment. As far as expression of genes for dementia the advice is to reduce inflamation ( fasting, HIIT excercise, low carb/keto, gut microbiome optimization). The way I understand what has been highlighted in this latest article by Walter lifestyle changes wont make much of a difference ( it was designed as bioweapon) . Below are the details for Long Covid Center recently opened in Adelaide focusing on understanding Long Covid.
Sorry all for this rant I feel compeled to help somehow but frustrated by my own incompetence.
Long COVID Assessment Clinic | Royal Adelaide Hospital
Please consider doing a compilation post, just on a high level summarizing the following:
1. Major pathogenic biochemical pathways and resulting pathological processes of the Wuhan strain spike protein (and derivates of thereof). No low level biochem pathways. Just : amyloidosis, fibrinosis, cancerous growth, etc.
2. Primary symptomology for detection prolonged / aggrevating circulation/replication of the spike protein in the body of a patient (i.e. list of symptoms to watch out for).
3. Primary laboratory / testing biomarkers for detection and measuring the severity / progression of pathological processes (from 1.), i.e. IL-6, IL-6, TNF-a, d-dimer, etc.
4. Known and possible interventions (medical, lifestyle, other) for stopping and/or reversing the pathological processes (e.g. amyloidosis, fibrosis, cancer) caused by the spike protein.
We can't wait for the research field to catch up on this, it moves at a glacial pace. There are millions of people out there needing help now. The milk has already spilled, can't put it back into bottle.
I'm trying (as per your links) study now the efficacy of the following as potential remedial interventions:
I would also explore old remedies that were renowned from history in various cultures. Hyssop, Schisandra, Black (Cumin) Seed Oil, etc. Hoping to find something easy to grow/accessible/affordable. The people's medicine.
Walter, I really miss seeing your posts on Twitter. I really enjoyed the break from science and seeing your dinner and wine selection. Are you posting on another platform like you did on Twitter?
Are long COVID patients getting wasting-away syndromes, whether or not cancer related? I haven’t heard much about long COVID other than it being a continuation of COVID symptoms, or what are almost surely vaccine injuries.
I’m assuming that the amyloid structures ultimately can cause prion diseases? Sorry to be asking such basic questions in a stack that is pretty technical.
I'm one of the first "Original Gangster" (OG) recovered covid long-haulers, who first came down with what we now call longcovid or PASC back in early 2020. It took me tons of research and dedication to adopt several simultaneous strategies to clear myself of relapses and symptoms, and I posted a video of the highlights of my recovery (including symptoms, reasoning, a bit of discussion about amyloid issues and some success strategies) on YouTube here:
To answer your questions: Yes, some (but not all) longhaulers are having trouble with wasting away, and having trouble maintaining weight. Others like myself have the opposite problem and ended up gaining weight we're having trouble losing. Many of us got covid early on, in 2020, prior to any of the vaccines. Some of us chose not to get any vaccines because we feel we've had enough spike proteins, and others got the jabs. Those of us who love reading thoughtful scientific articles, such the excellent work of Walter M Chesnut, are understandably wary of getting the vaccines.
Thanks for this answer and video link Cynthia. I’m glad you were able to knock it out using the various supplements and lifestyle changes that you chronicle. It does seem that those who have vaccine injuries have had less success, though though there have some who claim results. Dr. Aryiana Love, who has done great research on the bioweapon shots, has a protocol. Dr. Korry is treating vax victims but it costs about $1600. Surely worth it if it works.
Your explanation of Amyloidosis was clear and enlightening. I’m hopefully better able to follow the articles on this Stack. 
Yes, it seems that more spike protein toxins are released from receiving covid vaccines and booster shots than from natural covid infections--so it makes sense that it's rougher to fully recover from long-lasting, long-term negative effects for those who've been vaccinated. I'm hoping we can find simple, affordable, accessible spike protein detox procedures for everyone in the world; it's surely needed now.
@Cynthia, would love for you to look into whether Olive Leaf (extract) is useful for long haulers. I imagine therapeutic doses would need to be several grams a day. Dr. Levy has interesting research on a component of OLE restoring our ability to make endogenous vitamin C, which is a game changer if true.
Thank you, Ali! Yes, I am seeing one longhauler improve tremendously with a combination of Olive Leaf extract and HBOT (hyperbaric oxygen therapy). Not sure which one is making the bigger difference, but together, it's pulling one person out of longcovid, which is a blessing to witness.
I've also heard good things about HBOT! Great combo. OLE is very accessible, you can get 2lbs for <$40 on Amazon. Seems to synergize well with dietary EVOO and Lemons, and is supplemented well with olive leaf tea. I'm particularly interested in whatever solutions can be found that are most affordable/accessible/comprehensive. So many people are taking million supplements, but I think higher doses of fewer things might be more elegant.
I know there is a study regarding Long COVID at UCSD but I’m not sure how to get information about results or the program. I would assume these studies are happening all over. I also heard that one doctor at ucsd said COVID is definitely lab leak.
"Long COVID" was starting to be mentioned by mid-2020, before the jabs started to be rolled out. So definitely not jab-specific (though this does not rule out a jab-induced version).
❤Walter ❤ You are so lovingly intelligent, insightful and focused. I am speechless (scared). If anyone has any plan how to start facilitating answers to Walter's questions above please speak out.
Walter 's questions:
How do we mitigate the presence and potential self-propagating abilities of the Spike Protein?
Does repeated exposure to the Spike Protein, either via infection or vaccination induce and/or accelerate these processes?
How to ensure the world medical and research communities address and investigate these conclusions?
Brilliant work Sir. You are on the money with this and have been since the start. I had a mild 2 day infection, think it was covid as my facial and trigeminal nerves were electric. I began a course of lumbrokinase, NAC, quercetin and curcumin as a hopeful solution. Fingers crossed.
This makes perfect sense as to why all restrictions have been removed, let them mix, let them have multiple reinfections. Fatigue is a major issue with people, nausea in the mornings and the I don’t feel right but can’t put my finger on it. The way Ivermectin was rubbished, I’m hoping this impairs the spike. Thanks again Sir for your work and dedication
Flu type, shivering, but the facial pain made it different. Sweated unbelievably with no temp. Loss of taste for 1 day. Overall, 2 days unwell. Unjabbed. Was out running after a further 2 days albeit a slower time.
This is precisely the worse case scenario I feared could happen. . . as a result of making our body's cells create the spike protein. . . While the immune system is suppressed by the vaccines, some of all that spike injected may not be cleared by the immune system, and together with the new spike proteins produced by our own bodies, could continue to be produced for an extended period theoretically. . . This could happen equally; in those who catch the virus, and those vaccinated. Though, I read that the amount injected is far greater and goes straight into circulation, so could cause more problems.
Many thanks Walter. I can't help but wonder what will happen to people having the 'Novavax' jabs, being injected with an artificially generated spike protein directly (rather than instructing the body to self generate the spike through mRNA) .... will this spike protein also persist in the body despite what the manufacturer will no doubt claim? (Ps. Novavax is developing a Covid spike protein/regular flu combination 'vaccine' - the mind boggles)
I found this paper... well, informative and I was both impressed and pissed at what this group found in the spike mimics work they did. They identified a bunch of proteins (Timothy grass sequence too) and what they do. Just reading those and thinking of the other things we know...
The crafting involved in the virus continues to take my breath.
I understand the term oldest old refers to mid 80s and 90+ year-old people. I wond if W is saying that the effects of the spike produce characteristics of being very old, and it's being called long covid.
"The coronavirus SARS-CoV-2 is the cause of the ongoing pandemic of COVID-19. Given the absence of effective treatments against SARS-CoV-2, there is an urgent need for a molecular understanding of how the virus influences the machineries of the host cell. The SARS-CoV-2 generates 16 Non-Structural Proteins (NSPs) through proteolytic cleavage of a large precursor protein. In the present study, we focused our attention on the SARS-CoV-2 protein NSP2, whose role in the viral pathogenicity is poorly understood. Recent proteomic studies shed light on the capacity of NSP2 to bind the 4EHP-GIGYF2 complex, a key factor involved in microRNA-mediated silencing of gene expression in human cells. In order to gain a better understanding of the function of NSP2, we attempted to identify the molecular basis of its interaction with 4EHP-GIGYF2. Our data demonstrate that NSP2 physically associates with the endogenous 4EHP-GIGYF2 complex in the cytoplasm. Using co-immunoprecipitation and in vitro interaction assays, we identified both 4EHP and a central segment in GIGYF2 as binding sites for NSP2. We also provide functional evidence that NSP2 impairs the function of GIGYF2 in mediating mRNA silencing using reporter-based assays, thus leading to a reduced activity of microRNAs. Altogether, these data reveal the profound impact of NSP2 on the post-transcriptional silencing of gene expression in human cells, pointing out 4EHP-GIGYF2 targeting as a possible strategy of SARS-CoV-2 to take over the silencing machinery and to suppress host defenses."
I am going to be honest..this "Does repeated exposure to the Spike Protein, either via infection or vaccination induce and/or accelerate these processes?" is scary AF.
Yes. I am scared, too.
That concern rests entirely on the validity of this sentence:
"I reference again the Swedish paper above, to illustrate that not only is this mechanism how the Spike Protein induces Amyloidosis, but also how it PROPAGATES ITSELF WITHOUT THE PRESENCE OF THE VIRUS."
Without this, the spike is a toxin, nasty but something that can be dealt with in most cases via the body's detoxification systems. However if it can self-propagate then all bets are off.
I'm just not seeing it, extraordinary claims take extraordinary evidence as they say. It's an interesting theory but don't prions do their damage by inducing other (i.e. different) proteins to misfold? How can a spike protein create more spikes? I see how it can foul up other proteins (which is really bad of course) but how does it propagate itself?
Don't forget exposure to the vaccinated 'shedding' too. *shudder*
Transmission of the spike protein is a real concern for me, too.
I am Substacking the paper on the human amyloid proteins binding S1 today... in between all the other crap. Well done again my friend.
Jessica- please read my story in the comments on this post. This article exactly describes my situation. Thank you for EVERYTHING you do!
Reminiscent of a theory of ME/CFS called "Hit-and-Run", where no virus is found, but chronic panoply of symptoms persist. Perhaps a similar scenario as in your theory Walter.
That’s an interesting thread of thought!
Does EBV, an actual concomitant cause for long covid and ME/CFS, create this same scenario?
Are you talking Epstein Barr virus?? I’ve thought the whole time this was based on inciting EBV, the name alone, because this whole thing is a play on words. Most of this article is way above my understanding, but about 95% of all humans have Epstein Barr it would make sense that would be a target.
Epstein Barr Virus I meant, yes. Chronic EBV and reactivation of dormant EBV in a context of compromised immunity.
We have " Long.Covid assesment centre in Adelaide Australia. It seems to me they should be really reading Walter's articles and reaching out for collaboration. When I called an acquaintance who works there, i was told it is not how they operate.
Also, the University of Tasmania Dementia Reserach Centre. There are so many "research " pockets around the world looking at amyloid but no effective treatment. As far as expression of genes for dementia the advice is to reduce inflamation ( fasting, HIIT excercise, low carb/keto, gut microbiome optimization). The way I understand what has been highlighted in this latest article by Walter lifestyle changes wont make much of a difference ( it was designed as bioweapon) . Below are the details for Long Covid Center recently opened in Adelaide focusing on understanding Long Covid.
Sorry all for this rant I feel compeled to help somehow but frustrated by my own incompetence.
Long COVID Assessment Clinic | Royal Adelaide Hospital
https://www.rah.sa.gov.au/patients-and-visitors/conditions-services-and-clinics/medical-conditions/long-covid
Please consider doing a compilation post, just on a high level summarizing the following:
1. Major pathogenic biochemical pathways and resulting pathological processes of the Wuhan strain spike protein (and derivates of thereof). No low level biochem pathways. Just : amyloidosis, fibrinosis, cancerous growth, etc.
2. Primary symptomology for detection prolonged / aggrevating circulation/replication of the spike protein in the body of a patient (i.e. list of symptoms to watch out for).
3. Primary laboratory / testing biomarkers for detection and measuring the severity / progression of pathological processes (from 1.), i.e. IL-6, IL-6, TNF-a, d-dimer, etc.
4. Known and possible interventions (medical, lifestyle, other) for stopping and/or reversing the pathological processes (e.g. amyloidosis, fibrosis, cancer) caused by the spike protein.
We can't wait for the research field to catch up on this, it moves at a glacial pace. There are millions of people out there needing help now. The milk has already spilled, can't put it back into bottle.
I'm trying (as per your links) study now the efficacy of the following as potential remedial interventions:
I. EGCG and beta-carotene
https://doi.org/10.1002/mnfr.202000632
II. Betulinic Acid (from Chaga mushroom)
https://doi.org/10.1111/micc.12503
III. Baicalin / Baicalein (from Scutellaria baicalensis Georgi)
https://pubmed.ncbi.nlm.nih.gov/33579328/
IV. Spermidine (from wheatgerm oil, natto beans and cheddar)
https://doi.org/10.1007/s00508-020-01758-y
V. Enzymes (nattokinase, serrapeptase, lumbrokinase, streptokinase, bromelain)
https://pubmed.ncbi.nlm.nih.gov/34983344/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8194080/
https://pubmed.ncbi.nlm.nih.gov/32484078/
Or if removing amyloid plagues and/or fibrils is the wrong approach, please suggest a potential avenue to research.
Thank you for all your hard work! ❤️
Also look into Olive Leaf (extract, hydroxytyrosol, oleuropein). I've seen studies on its effects on IL-B, IL-6, TNF-a, etc. Also was used by HIV/AIDS patients to restore CD4/8 ratios. (Recommend this Book: https://archive.org/details/isbn_9781575662268/page/120/mode/2up?q=CD4)
https://www.mdpi.com/2076-3921/11/4/629
I would also explore old remedies that were renowned from history in various cultures. Hyssop, Schisandra, Black (Cumin) Seed Oil, etc. Hoping to find something easy to grow/accessible/affordable. The people's medicine.
Excellent list, thanks!
Walter, I really miss seeing your posts on Twitter. I really enjoyed the break from science and seeing your dinner and wine selection. Are you posting on another platform like you did on Twitter?
Are long COVID patients getting wasting-away syndromes, whether or not cancer related? I haven’t heard much about long COVID other than it being a continuation of COVID symptoms, or what are almost surely vaccine injuries.
I’m assuming that the amyloid structures ultimately can cause prion diseases? Sorry to be asking such basic questions in a stack that is pretty technical.
Thanks for this article.
I'm one of the first "Original Gangster" (OG) recovered covid long-haulers, who first came down with what we now call longcovid or PASC back in early 2020. It took me tons of research and dedication to adopt several simultaneous strategies to clear myself of relapses and symptoms, and I posted a video of the highlights of my recovery (including symptoms, reasoning, a bit of discussion about amyloid issues and some success strategies) on YouTube here:
What does China know that they're not saying?
And my recovery from longhaul covid
https://youtu.be/feqoj_5aRJk
To answer your questions: Yes, some (but not all) longhaulers are having trouble with wasting away, and having trouble maintaining weight. Others like myself have the opposite problem and ended up gaining weight we're having trouble losing. Many of us got covid early on, in 2020, prior to any of the vaccines. Some of us chose not to get any vaccines because we feel we've had enough spike proteins, and others got the jabs. Those of us who love reading thoughtful scientific articles, such the excellent work of Walter M Chesnut, are understandably wary of getting the vaccines.
Thanks for this answer and video link Cynthia. I’m glad you were able to knock it out using the various supplements and lifestyle changes that you chronicle. It does seem that those who have vaccine injuries have had less success, though though there have some who claim results. Dr. Aryiana Love, who has done great research on the bioweapon shots, has a protocol. Dr. Korry is treating vax victims but it costs about $1600. Surely worth it if it works.
Your explanation of Amyloidosis was clear and enlightening. I’m hopefully better able to follow the articles on this Stack. 
Yes, it seems that more spike protein toxins are released from receiving covid vaccines and booster shots than from natural covid infections--so it makes sense that it's rougher to fully recover from long-lasting, long-term negative effects for those who've been vaccinated. I'm hoping we can find simple, affordable, accessible spike protein detox procedures for everyone in the world; it's surely needed now.
@Cynthia, would love for you to look into whether Olive Leaf (extract) is useful for long haulers. I imagine therapeutic doses would need to be several grams a day. Dr. Levy has interesting research on a component of OLE restoring our ability to make endogenous vitamin C, which is a game changer if true.
Olive Leaf (extract, hydroxytyrosol, oleuropein). I've seen studies on its effects on IL-B, IL-6, TNF-a, etc. Also was used by HIV/AIDS patients to restore CD4/8 ratios. (Recommend this Book: https://archive.org/details/isbn_9781575662268/page/120/mode/2up?q=CD4)
Also might help with amyloidosis.
https://www.mdpi.com/2076-3921/11/4/629
Thank you, Ali! Yes, I am seeing one longhauler improve tremendously with a combination of Olive Leaf extract and HBOT (hyperbaric oxygen therapy). Not sure which one is making the bigger difference, but together, it's pulling one person out of longcovid, which is a blessing to witness.
I've also heard good things about HBOT! Great combo. OLE is very accessible, you can get 2lbs for <$40 on Amazon. Seems to synergize well with dietary EVOO and Lemons, and is supplemented well with olive leaf tea. I'm particularly interested in whatever solutions can be found that are most affordable/accessible/comprehensive. So many people are taking million supplements, but I think higher doses of fewer things might be more elegant.
DMSO is another one that might be interesting.
I know there is a study regarding Long COVID at UCSD but I’m not sure how to get information about results or the program. I would assume these studies are happening all over. I also heard that one doctor at ucsd said COVID is definitely lab leak.
"Long COVID" was starting to be mentioned by mid-2020, before the jabs started to be rolled out. So definitely not jab-specific (though this does not rule out a jab-induced version).
Yes I am a perfect example of Cachexia- please read my story in the comments.
✋I’ve lost a lot of weight (mostly muscle) and feel like I’m wasting away. LC. No vax.
Same! I’ve lost 65 lbs unintentionally in 18 months. Please see my story in comments. I hope you recover.
❤Walter ❤ You are so lovingly intelligent, insightful and focused. I am speechless (scared). If anyone has any plan how to start facilitating answers to Walter's questions above please speak out.
Walter 's questions:
How do we mitigate the presence and potential self-propagating abilities of the Spike Protein?
Does repeated exposure to the Spike Protein, either via infection or vaccination induce and/or accelerate these processes?
How to ensure the world medical and research communities address and investigate these conclusions?
Brilliant work Sir. You are on the money with this and have been since the start. I had a mild 2 day infection, think it was covid as my facial and trigeminal nerves were electric. I began a course of lumbrokinase, NAC, quercetin and curcumin as a hopeful solution. Fingers crossed.
This makes perfect sense as to why all restrictions have been removed, let them mix, let them have multiple reinfections. Fatigue is a major issue with people, nausea in the mornings and the I don’t feel right but can’t put my finger on it. The way Ivermectin was rubbished, I’m hoping this impairs the spike. Thanks again Sir for your work and dedication
Interesting. Were those your only symptoms? I have had something similar. Facial type pain and all my teeth (molars) hurting.
Flu type, shivering, but the facial pain made it different. Sweated unbelievably with no temp. Loss of taste for 1 day. Overall, 2 days unwell. Unjabbed. Was out running after a further 2 days albeit a slower time.
How do u mitigate the spike protein? HCQ? IVM?
Here's place to start:
https://worldcouncilforhealth.org/resources/spike-protein-detox-guide/
Also look at the FLCCC pages.
This is precisely the worse case scenario I feared could happen. . . as a result of making our body's cells create the spike protein. . . While the immune system is suppressed by the vaccines, some of all that spike injected may not be cleared by the immune system, and together with the new spike proteins produced by our own bodies, could continue to be produced for an extended period theoretically. . . This could happen equally; in those who catch the virus, and those vaccinated. Though, I read that the amount injected is far greater and goes straight into circulation, so could cause more problems.
Walter, I wrote a post citing you.
https://2ndsmartestguyintheworld.substack.com/p/bombshell-irrefutable-proof-of-premeditated
I defer to you as the expert.
Many thanks Walter. I can't help but wonder what will happen to people having the 'Novavax' jabs, being injected with an artificially generated spike protein directly (rather than instructing the body to self generate the spike through mRNA) .... will this spike protein also persist in the body despite what the manufacturer will no doubt claim? (Ps. Novavax is developing a Covid spike protein/regular flu combination 'vaccine' - the mind boggles)
Excellent essay again, Walter.
I found this paper... well, informative and I was both impressed and pissed at what this group found in the spike mimics work they did. They identified a bunch of proteins (Timothy grass sequence too) and what they do. Just reading those and thinking of the other things we know...
The crafting involved in the virus continues to take my breath.
Potential autoimmunity resulting from molecular mimicry between SARS-CoV-2 Spike and human proteins https://www.biorxiv.org/content/10.1101/2021.08.10.455737v3
What does "oldest old" mean?
I understand the term oldest old refers to mid 80s and 90+ year-old people. I wond if W is saying that the effects of the spike produce characteristics of being very old, and it's being called long covid.
Understood. Thanks!
Walter, what's your thoughts on this one? https://www.thailandmedical.news/news/breaking-hypothesis-that-majority-exposed-to-sars-cov-2-will-have-shortened-lifespans-validated-by-study-showing-nsp2-impairs-human-4ehp-gigyf2-comple
Hmmm... https://www.biorxiv.org/content/10.1101/2022.01.25.477753v1
"The coronavirus SARS-CoV-2 is the cause of the ongoing pandemic of COVID-19. Given the absence of effective treatments against SARS-CoV-2, there is an urgent need for a molecular understanding of how the virus influences the machineries of the host cell. The SARS-CoV-2 generates 16 Non-Structural Proteins (NSPs) through proteolytic cleavage of a large precursor protein. In the present study, we focused our attention on the SARS-CoV-2 protein NSP2, whose role in the viral pathogenicity is poorly understood. Recent proteomic studies shed light on the capacity of NSP2 to bind the 4EHP-GIGYF2 complex, a key factor involved in microRNA-mediated silencing of gene expression in human cells. In order to gain a better understanding of the function of NSP2, we attempted to identify the molecular basis of its interaction with 4EHP-GIGYF2. Our data demonstrate that NSP2 physically associates with the endogenous 4EHP-GIGYF2 complex in the cytoplasm. Using co-immunoprecipitation and in vitro interaction assays, we identified both 4EHP and a central segment in GIGYF2 as binding sites for NSP2. We also provide functional evidence that NSP2 impairs the function of GIGYF2 in mediating mRNA silencing using reporter-based assays, thus leading to a reduced activity of microRNAs. Altogether, these data reveal the profound impact of NSP2 on the post-transcriptional silencing of gene expression in human cells, pointing out 4EHP-GIGYF2 targeting as a possible strategy of SARS-CoV-2 to take over the silencing machinery and to suppress host defenses."