FURTHER UNIFICATION OF SPIKE PROTEIN MICROVASCULAR DISEASE AND TAUOPATHY: TLR-2

Mimicking radiation damage via NF-kB activation via TLR-2

I believe I can now fully explain why Tauopathies are occurring in association with SARS-CoV-2 and its Spike Protein. Radiation PERMANENTLY alters NF-kB expression and reprograms endothelial cells resulting in vascular disease. The very same activation also increases the effects of ALL risk factors associated with Alzheimer’s Disease.

Of course, SARS-CoV-2 is NOT radiation. However the Spike Protein MIMICKS THE EFFECTS OF RADIATION EXACTLY including activation of NF-kB via TLR-2.

This also explains why the elderly are far more at risk of IMMEDIATE severe disease and death. Young mice have virtually NO NF-kB levels in their Hypothalamus!

Now, the major concern is that, if the Spike Protein’s activation of NF-kB is PERMANENT, as it appears to be with Radiation exposure, are all those infected/transfected on an ACCELERATED path to the microvasculature and neurodegeneration of the oldest old?

Additionally, are the effects CUMULATIVE? Or, INCREMENTAL? Is it like starting a lawnmower? Eventually a pull of the string is going to start the engine?

There is so much to investigate here. I am certain this is the correct path.

I have also listed some therapeutics which I believe should be investigated as well.

If you wish to dive further into this explanation, please read the referenced papers. They are all excellent.

Thank you all for your support and encouragement. I will keep working.

The Response of the Microvascular System to Radiation: A Review
https://www.tandfonline.com/doi/abs/10.3109/07357908909039849

Association of small vessel disease with tau pathology
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8858293/

Understanding Radiation-Induced Vascular Disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807611/

SARS-CoV-2 spike promotes inflammation and apoptosis through autophagy by ROS-suppressed PI3K/AKT/mTOR signaling
https://pubmed.ncbi.nlm.nih.gov/34461258/

SARS-CoV-2 and pathological matrix remodeling mediators
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8294315/

SARS-CoV-2 Spike Protein 1 Activates Microvascular Endothelial Cells and Complement System Leading to Platelet Aggregation
https://www.frontiersin.org/articles/10.3389/fimmu.2022.827146/full

SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathway
https://elifesciences.org/articles/68563

Nitric Oxide: The Missing Factor in COVID-19 Severity?
https://www.mdpi.com/2076-3271/10/1/3/htm

Nuclear Factor-Kappa B and Alzheimer Disease, Unifying Genetic and Environmental Risk Factors from Cell to Humans
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732234/