Friday Hope: Resveratrol Revisited: Protecting DNA and a SARS-CoV-2 Antiviral/Spike Protein Injury Therapeutic
Mimics the effects of caloric restriction and is less toxic than chloroquine as an antiviral.
Natural compounds that enhance the effects of radio and chemotherapy by affecting DNA repair mechanisms in cancer cells. DNA damaging agents used in cancer treatment induce a diverse spectrum of toxic lesions. These injuries are recognized by a variety of DNA repair pathways that are specific to the injury but are complementary in some respects. Natural compounds enhance the effects of these toxic agents by preventing proper DNA repair and inducing cell death. DNA repair pathways involved are: base-excision repair (BER), nucleotide-excision repair (NER), alkyltransferases (ATs), mismatch repair (MMR), non-homologous end joining (NHEJ), homologous recombination (HR), endonuclease mediated repair (ENDO), Fanconi anaemia repair (FA), DNA dioxygenases (O2G), and RecQ-mediated repair (RecQ). The size of the boxes represents the relative contribution of each repair mechanism in each type of damage caused by a type of treatment.
Resveratrol continues to impress. It is a nutraceutical which has, deservedly, garnered a lot of attention recently due to its wide range of hypothesized and proven beneficial effects in treating human disease.
Resveratrol is a nutraceutical with several therapeutic effects. It has been shown to mimic effects of caloric restriction, exert anti-inflammatory and anti-oxidative effects, and affect the initiation and progression of many diseases through several mechanisms.
Please note that these effects have independently been proven to contribute to beneficial outcomes in SARS-CoV-2/Spike Protein disease. Therefore, it is immensely logical to conclude that any therapeutic which enhances these outcomes would be desirable.
Given the DNA damage that the Spike Protein has been shown to cause, the ability of Resveratrol to activate SIRT1 is significant as a prophylactic and therapeutic for Spike Protein injury. It also shows great benefit via regulating cellular senescence, endothelial functions and circadian rhythms. Again, all dysregulated by the Spike Protein.
Resveratrol is an activator of SIRT1, one of the mammalian forms of the sirtuin family of proteins.7 SIRT1 deacetylates histones and nonhistone proteins including transcription factors. The SIRT1-regulated pathway affects metabolism, stress resistance, cell survival, cellular senescence, inflammation-immune function, endothelial functions, and circadian rhythms. Resveratrol has been shown to activate SIRT1 and therefore is predicted to benefit diseases affected by abnormal metabolic control, inflammation, and cell cycle defects.
The therapeutic potential of resveratrol: a review of clinical trials
https://www.nature.com/articles/s41698-017-0038-6
Apart from its ability to be effective vs the Spike Protein and SARS-CoV-2, Resveratrol is also effective in a wide range of human diseases.
Clinical benefits of resveratrol
Resveratrol has been shown to directly benefit outcomes related to SARS-CoV-2 infection.
Recently a randomized double-blind placebo-controlled proof-of-concept trial of resveratrol demonstrated that the resveratrol group had a lower incidence of hospitalization, COVID-related emergency room visits, and pneumonia compared to the placebo group of outpatients with mild COVID-19.
The potential role of resveratrol as supportive antiviral in treating conditions such as COVID-19 – A formulator’s perspective
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8884665/
As readers of my Substack know, it is apparent that the Spike Protein mimics the damage caused to DNA by radiation. This is yet another instance where Resveratrol may prove extremely useful.
As an anti-cancer compound, low-dose resveratrol accelerates non-mutagenic repair of DNA damage in mouse embryonic stem cells exposed to ionizing radiation. Similarly, resveratrol in mouse embryonic fibroblasts was shown to help maintain genomic stability after chemical and ionizing radiation damage by allowing greater repair efficiency of double-strand breaks and less replicative stress.
Natural Compounds That Target DNA Repair Pathways and Their Therapeutic Potential to Counteract Cancer Cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710985/
I urge clinicians and research institutions to trial Resveratrol as a therapeutic and prophylactic for SARS-CoV-2 infection, Long COVID and Spike Protein injury. The above is an article of medical research and is not medical advice. As with all medications and supplements, check with your Primary Care Provider before using any medicines or supplements.
I wish you all a joyous late-summer weekend. Thank you for your continued financial support. It allows me to work towards a more complete understanding of SARS-CoV-2, its Spike Protein, and most importantly, therapeutics to treat those infected, injured and suffering from Long COVID.
One of my sons is a genetic engineer with a Fortune 100 company. Years ago he told me resveratrol was a scam. But lately he has been saying, "there might be something to it". I should add that I know WAY more than him about all aspects of the covid vax even though I don't have a medical degree. I should though after the last 3 years.
It looks like its functions overlap a good bit with berberine.
Pity we cannot get funding to do a head-to-head trial of the two.