The most well known researcher in cellular anti-aging is probably David Sinclair (author of Lifespan) and he is pretty open about his drug/supplement stack:
He takes Resveratrol — 1000 mg per day (in the morning, taken with yogurt or olive oil).
He explains in his book that it needs some fat with it, so he usually mixes the powder into a tablespoon of yoghurt.
Note that his regimen also includes metformin (another drug Walter has highlighted), which is great for improving metabolic health / insulin sensitivity. That's a prescription drug in most places though, so you can switch that out for Berberine (500mg, twice a day) for an over-the-counter, natural supplement that functions similarly.
Living in the wine country, show me a wine that does not contain sulfites and taste and colour adjuvants? There goes the resveratrol sulfites will kill the benefits, a direct assault on the microbiome and who can afford a wine without these?....20, 30$ and more and even then.
I can’t easily find what dosage thatwas used in some of the studies you cited. Would you mind sharing this information? Just doing some googling it looks like a therapeutic dose might have to be much higher than a typical supplement somewhere in the range of 2 mg or more?
We believe resveratrol is present in the formulation we have along with quercetin, Apeginin and Luteolin. This is an ongoing development so please sign up to follow. https://www.archaealife.com
From the study "Resveratrol has been shown to upregulate ACE2. A deficiency of ACE2 caused by SARS is associated with lung injury. The upregulation of ACE2 by resveratrol might provide protective effects in COVID-19". my note: might? depending on the timing of resveratrol treatment? in what population? Yes, resveratrol is in my "old person" covid kit.
Despite what the establishment, maintain the treatment status quo, faked up, misreported studies supporting the continuation of blood pressure drugs that cause a great up-regulation of ACE2, these studies actually do show a substantial increased risk from covid especially in the elderly attributable to the greatly increased number of ACE2 for the viral binding. Thus the timing of the up-regulation of ACE2 may be important especially in the elderly, possibily indicating "not so much for prevention", yes, asap for early treatment, who knows?
With the "development" of both increasingly infective and virulent variants maxing out, to date, with gamma P1? Then the 2 year development of omicron with its "developed" much higher infectivity with "developed" ability to bind to many many cell surface receptors and gain cell entry and lower, at least initial, virulence, though still causing problems for the multi-vaxed and multi-infected immune system -
who knows? the relative effect of resveratrol up-regulation of ACE2, especially when compared to the up-regulation of ACE2 caused by blood pressure drugs, now that omicron is circulating. Yes, I am still taking some lisinopril and practice, so far at least, effective prevention.
In these studies, what was considered a low dose in terms of like mg for your average say 60, 80 or 100kg adult? How does usually below 10 μM and 25 μM translate in terms of say if we were to supplement in mg per day?
Red, red wine.
Yeah, I like my resveratrol liquid-style! 🍷 (though I do take caps too)
grapes, too? or is there something in the fermenting process/
Hi Walter -- How would people know what dose to take?
The most well known researcher in cellular anti-aging is probably David Sinclair (author of Lifespan) and he is pretty open about his drug/supplement stack:
https://us.foryouth.co/news/which-supplements-does-longevity-expert-dr-david-sinclair-take?
He takes Resveratrol — 1000 mg per day (in the morning, taken with yogurt or olive oil).
He explains in his book that it needs some fat with it, so he usually mixes the powder into a tablespoon of yoghurt.
Note that his regimen also includes metformin (another drug Walter has highlighted), which is great for improving metabolic health / insulin sensitivity. That's a prescription drug in most places though, so you can switch that out for Berberine (500mg, twice a day) for an over-the-counter, natural supplement that functions similarly.
Thank you!
How much is a low dose of resveratrol?
dosage recommendations run pretty wide. I take a 200mg once daily. FLCCC I think recommends 400-500mg in their Covid/flu prevention protocol.
I think it’s 100 mg
David Sinclair (famous aging researcher / writer) takes 1000 mg per day, in the mornings.
He mixes into a spoon of yoghurt or a bit of olive oil, as it needs the fats to be taken up optimally.
His supplement stack is here: https://us.foryouth.co/news/which-supplements-does-longevity-expert-dr-david-sinclair-take?
Next question how much resveratrol in a 5oz glass of wine? 1mg
Living in the wine country, show me a wine that does not contain sulfites and taste and colour adjuvants? There goes the resveratrol sulfites will kill the benefits, a direct assault on the microbiome and who can afford a wine without these?....20, 30$ and more and even then.
Party pooper. J/k. :)
Lol
the answer is to only purchase the better quality as often as able, and do without until you can
There’s no guarantee that the better quality is free from fraude, and talking about biological wines most are comparable to dishwater, not puke proof
I can’t easily find what dosage thatwas used in some of the studies you cited. Would you mind sharing this information? Just doing some googling it looks like a therapeutic dose might have to be much higher than a typical supplement somewhere in the range of 2 mg or more?
We believe resveratrol is present in the formulation we have along with quercetin, Apeginin and Luteolin. This is an ongoing development so please sign up to follow. https://www.archaealife.com
At what dose?
1000mg a day, in the morning. It needs a little fat with it for optimal uptake, so have it with a spoon of full fat yoghurt, or olive oil.
Will a bottle of red per night be overkill? Seriously, though, excellent article and I shall be investing in Resveratrol.
Polygonum Cuspidatum Containing Resveratrol
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665013/
https://neurohacker.com/formulation/polygonum-cuspidatum-root-extract-95-resveratrol
https://www.rolv.no/urtemedisin/medisinplanter/reyn_jap.htm
Pass the wine, please.
From your typing fingers to God’s “ear” Walter!
Lingonberries grow abundantly around our house. We pick them in the fall, freeze them and eat them year round. They are high in resveratrol.
From the study "Resveratrol has been shown to upregulate ACE2. A deficiency of ACE2 caused by SARS is associated with lung injury. The upregulation of ACE2 by resveratrol might provide protective effects in COVID-19". my note: might? depending on the timing of resveratrol treatment? in what population? Yes, resveratrol is in my "old person" covid kit.
Despite what the establishment, maintain the treatment status quo, faked up, misreported studies supporting the continuation of blood pressure drugs that cause a great up-regulation of ACE2, these studies actually do show a substantial increased risk from covid especially in the elderly attributable to the greatly increased number of ACE2 for the viral binding. Thus the timing of the up-regulation of ACE2 may be important especially in the elderly, possibily indicating "not so much for prevention", yes, asap for early treatment, who knows?
With the "development" of both increasingly infective and virulent variants maxing out, to date, with gamma P1? Then the 2 year development of omicron with its "developed" much higher infectivity with "developed" ability to bind to many many cell surface receptors and gain cell entry and lower, at least initial, virulence, though still causing problems for the multi-vaxed and multi-infected immune system -
who knows? the relative effect of resveratrol up-regulation of ACE2, especially when compared to the up-regulation of ACE2 caused by blood pressure drugs, now that omicron is circulating. Yes, I am still taking some lisinopril and practice, so far at least, effective prevention.
In these studies, what was considered a low dose in terms of like mg for your average say 60, 80 or 100kg adult? How does usually below 10 μM and 25 μM translate in terms of say if we were to supplement in mg per day?
A glass of red wine with your evening meal?