Due to type 2 diabetes my husband had to go Metformin years ago. The first few weeks were very uncomfortable for his stomach. I gave him yogurt and peppermint (Altoids). (Has to be real peppermint.) One he got through this adjustment stage he has been fine. Some of the new diabetes drugs side effects look very scary to us. We're staying with Metformin.
Wow. But could it be the presence of diabetes at fault? That is, if a non-diabetic took Metformin, would this act in a prophylactic way against the bio weapon?
I have it every day after I am done eating for the day, I allow myself a 3 to 5 hr feeding window, for the rest I am fasting. I noticed that I am in ketosis faster in the morning instead of early afternoon. It practically doubles the ketosis or the time where I live of my fats, it's a nicer feeling more diffuse, smoother on the digestive tract system. I am a 55 year old athlete, use it as an enhancement, I do not suffer from anything out of the ordinary.
This might sound bizarre, but when Russia, in the beginning of the special military operation and countered one of the bio labs, they were going through I guess with a GoPro and he was the soldier was looking at the paperwork, and it was written in English and one of the pieces of paper that he picked up and looked at was about metformin which my mother-in-law takes anyway one of the ingredients stated in that paper was rocket fuel.
Have you also considered berberine? To be honest, I am losing some wait right now and was up in the air about metformin or Berberine. I'm still up in the air after reading this.
Based on the provided search results, here's a comprehensive analysis:
Magnesium Malate:
Magnesium malate has been shown to improve energy production in mitochondria by enhancing ATP generation (as mentioned in the "The Powerful Anti-Aging and Longevity Benefits of Magnesium Malate" snippet).
Based on the provided search results, here’s a comprehensive analysis:
Magnesium Malate:
Magnesium malate has been shown to improve energy production in mitochondria by enhancing ATP generation (as mentioned in the “The Powerful Anti-Aging and Longevity Benefits of Magnesium Malate” snippet).
Magnesium is essential for mitochondrial function and can potentially delay the onset of mitochondrial dysfunction associated with aging (as highlighted in the “The Pivotal Role of Magnesium in Healthy Aging: A Comprehensive Review” snippet).
Magnesium is involved in epigenetic processes, such as DNA methylation, which can influence gene expression and potentially delay the onset of aging-related diseases (as mentioned in the “The Pivotal Role of Magnesium in Healthy Aging: A Comprehensive Review” snippet).
N-Acetylcysteine (NAC):
NAC has been shown to have antioxidant and anti-inflammatory properties, which may help mitigate oxidative stress and inflammation associated with aging (not directly addressed in the provided search results, but relevant to the broader context of aging).
Combination of Magnesium Malate and NAC:
While there is no direct evidence specifically combining magnesium malate and NAC to mitigate epigenetic drift and mitochondrial dysfunction in aging or senescent cells, the individual benefits of each compound can be considered:
Magnesium malate’s impact on mitochondrial function and energy production may help alleviate mitochondrial dysfunction, a hallmark of aging.
NAC’s antioxidant and anti-inflammatory properties may help reduce oxidative stress and inflammation, which can contribute to epigenetic drift and cellular senescence.
The combination of these two compounds may have a synergistic effect, potentially enhancing their individual benefits and mitigating epigenetic drift and mitochondrial dysfunction in aging or senescent cells.
In conclusion, while the evidence is indirect, the combination of magnesium malate and NAC may have a beneficial effect on mitigating epigenetic drift and mitochondrial dysfunction in aging or senescent cells. However, further research is needed to specifically investigate this combination and its effects on these cellular processes.
Genetics
How can microdialysis benefit drug development
Study: Magnesium and the Hallmarks of Aging. Image Credit: monticello / Shutterstock.com
I've heard it causes insane gastrointestinal issues. Lots of people stop taking it for this reason.
Due to type 2 diabetes my husband had to go Metformin years ago. The first few weeks were very uncomfortable for his stomach. I gave him yogurt and peppermint (Altoids). (Has to be real peppermint.) One he got through this adjustment stage he has been fine. Some of the new diabetes drugs side effects look very scary to us. We're staying with Metformin.
not in my experience...
which of course doesnt mean much.
but my patients who got sickest were ALL on metformin. and many developed LC
Wow. But could it be the presence of diabetes at fault? That is, if a non-diabetic took Metformin, would this act in a prophylactic way against the bio weapon?
Maybe so.
Berberine is a close analog, according to Moriarty, another substacker I follow.
I have it every day after I am done eating for the day, I allow myself a 3 to 5 hr feeding window, for the rest I am fasting. I noticed that I am in ketosis faster in the morning instead of early afternoon. It practically doubles the ketosis or the time where I live of my fats, it's a nicer feeling more diffuse, smoother on the digestive tract system. I am a 55 year old athlete, use it as an enhancement, I do not suffer from anything out of the ordinary.
My 77-year-old mother-in-law in a house full of teenagers coming and going never got sick. She was on metformin
This might sound bizarre, but when Russia, in the beginning of the special military operation and countered one of the bio labs, they were going through I guess with a GoPro and he was the soldier was looking at the paperwork, and it was written in English and one of the pieces of paper that he picked up and looked at was about metformin which my mother-in-law takes anyway one of the ingredients stated in that paper was rocket fuel.
Have you also considered berberine? To be honest, I am losing some wait right now and was up in the air about metformin or Berberine. I'm still up in the air after reading this.
Based on the provided search results, here's a comprehensive analysis:
Magnesium Malate:
Magnesium malate has been shown to improve energy production in mitochondria by enhancing ATP generation (as mentioned in the "The Powerful Anti-Aging and Longevity Benefits of Magnesium Malate" snippet).
Magnesium is essential for mitochondrial function and can potentially delay the onset of mitochondrial… https://search.brave.com/search?q=Can+the+combination+of+magnesium+malate+and+NAC+mitigate+epigenetic+drift+and+mitochondrial+dysfunction+in+aging+or+senescent+cells%3F&summary=%7B%22query%22%3A%22Can+the+combination+of+magnesium+malate+and+NAC+enhance+epigenetic+modifications+or+mitochondrial+function+in+specific+cellular+contexts%3F%22%2C%22country%22%3A%22us%22%2C%22language%22%3A%22en%22%2C%22safesearch%22%3A%22moderate%22%2C%22results_hash%22%3A%223b5f86bf052c526846e1374870ddb10adbd4fd72328ceea05a260fd4cf55c2ab%22%2C%22context%22%3A%7B%22query%22%3A%22How+do+the+different+metabolic+pathways+of+magnesium+malate+and+NAC+%28one+largely+non-metabolized%2C+the+other+metabolized+to+cysteine%29+influence+their+potential+interactions+and+clinical+effects%3F%22%2C%22country%22%3A%22us%22%2C%22language%22%3A%22en%22%2C%22safesearch%22%3A%22moderate%22%2C%22results_hash%22%3A%22c667b3af7646f292c86169460d8a69a694ccd1d5101b5a7e3cde386b653f283d%22%2C%22context%22%3A%7B%22query%22%3A%22How+do+the+pharmacokinetic+profiles+of+magnesium+malate+and+NAC+influence+their+interaction%2C+and+could+this+impact+efficacy+or+toxicity%3F%22%2C%22country%22%3A%22us%22%2C%22language%22%3A%22en%22%2C%22safesearch%22%3A%22moderate%22%2C%22results_hash%22%3A%22ad8daec6dc405fd78e1d431e9976dc050418f764df16a0489e2a6af9129a273a%22%2C%22context%22%3A%7B%22query%22%3A%22synergistic+and+antaganistic+interactions+between+magnesium+malate+and+nac%22%2C%22country%22%3A%22us%22%2C%22language%22%3A%22en%22%2C%22safesearch%22%3A%22moderate%22%2C%22results_hash%22%3A%220111bba2dd39f3fd4fd3369935c1eaf332dcf3d10b128c840c10d0a35de3f14a%22%7D%7D%7D%7D&source=llmFollowup&summary_og=afd369ac4720e2483a0d32
Magnesium-NAC's Epigenetic Mitigation
Based on the provided search results, here’s a comprehensive analysis:
Magnesium Malate:
Magnesium malate has been shown to improve energy production in mitochondria by enhancing ATP generation (as mentioned in the “The Powerful Anti-Aging and Longevity Benefits of Magnesium Malate” snippet).
Magnesium is essential for mitochondrial function and can potentially delay the onset of mitochondrial dysfunction associated with aging (as highlighted in the “The Pivotal Role of Magnesium in Healthy Aging: A Comprehensive Review” snippet).
Magnesium is involved in epigenetic processes, such as DNA methylation, which can influence gene expression and potentially delay the onset of aging-related diseases (as mentioned in the “The Pivotal Role of Magnesium in Healthy Aging: A Comprehensive Review” snippet).
N-Acetylcysteine (NAC):
NAC has been shown to have antioxidant and anti-inflammatory properties, which may help mitigate oxidative stress and inflammation associated with aging (not directly addressed in the provided search results, but relevant to the broader context of aging).
Combination of Magnesium Malate and NAC:
While there is no direct evidence specifically combining magnesium malate and NAC to mitigate epigenetic drift and mitochondrial dysfunction in aging or senescent cells, the individual benefits of each compound can be considered:
Magnesium malate’s impact on mitochondrial function and energy production may help alleviate mitochondrial dysfunction, a hallmark of aging.
NAC’s antioxidant and anti-inflammatory properties may help reduce oxidative stress and inflammation, which can contribute to epigenetic drift and cellular senescence.
The combination of these two compounds may have a synergistic effect, potentially enhancing their individual benefits and mitigating epigenetic drift and mitochondrial dysfunction in aging or senescent cells.
In conclusion, while the evidence is indirect, the combination of magnesium malate and NAC may have a beneficial effect on mitigating epigenetic drift and mitochondrial dysfunction in aging or senescent cells. However, further research is needed to specifically investigate this combination and its effects on these cellular processes.
Genetics
How can microdialysis benefit drug development
Study: Magnesium and the Hallmarks of Aging. Image Credit: monticello / Shutterstock.com
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ncbi.nlm.nih.gov
The Involvement of Mg2+ in Regulation of Cellular and Mitochondrial Functions - PMC
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novoslabs.com
The Powerful Anti-Aging and Longevity Benefits of Magnesium Malate
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medriva.com
The Pivotal
Do aspirin next!