Those with Major Depressive Disorder Already Have a Compromised Endothelium. Escitalopram Mitigates the Damaged Endothelium – Particularly the Microvasculature.
Walter... Excellent find. Do you think fluvoxamine is similar in effect on microvasc and endothelium?
Yes, it has. I have been writing this for over two years.
Methylene Blue has helped me so much with my long Covid issues. It’s the first supplement (if you want to call it that) that I’ve really noticed a big difference with. The brain fog/dizziness is gone. My energy level jumped way up. I still have tinnitus unfortunately, but I can deal with that.
I’d be curious to see the correlation… I wonder if people with anxiety disorders disproportionately went to the murder factories -er… hospitals, when they got COVID symptoms, while all the people I would call normal, just lived life as normal and took chicken soup for it…
Chondroitin sulfate protects vascular endothelial cells from toxicities of extracellular histones
Would you hazard a guess as to possible use / utility of SNRI-type antidepressants in treating Long Covid?
Lexapro or SPED, Lexapro or SPED, Lexapro or SPED, .... I'm thinking!
Not a big fan of SSRIs.
I cannot imagine taking a psychotropic with God knows how many life altering side effects.
Look at this from the other point of view.
Consider SAD (Seasonal Affective Disorder) which has been characterised (and treated) as a pineal response to inadequate sunlight. Another hypothesis (and therapy) for SAD and depression has been Vitamin D supplementation.
There are many studies of the correlation between Vit. D levels and Covid severity. Dr. Ryan Cole has stated that Vit. D levels above 50 ng/ml are protective.
So, I now look at the correlation between Major Depressive Disorder, endothelial dysfunction, and antidepressant therapy as a marker for Vit. D deficiency.
For some decades I reminded patients that they existed on the "health" of their arterial linings- particularly diabetics, smokers, and those with established coronary artery or vascular disease. Latterly I also suggested that those who manifested SAD use the lights, but also occasionally suggested Vit. D supplementation. Over the past three years I have become very much more aware of the requirement to also assess Vit. D levels, but have not been in clinic.
One of the interesting observations is that endothelial dysfunction is a protean symptom complex. Any vulnerable tissue can be affected and give its typical diagnostic cluster. This is one of the (perhaps intentional) reasons that the spike protein pathology has not been obvious- there are so many manifestations that each one is "only a little bit above normal" that the overall disaster can be dismissed until the total damage is presented.
Thank you for your work on this subject.