Friday Hope: CoQ10: Antiarrhythmic Properties May Help Athletes, Performers and Pilots

Studies indicate CoQ10 reduces the risk of arrhythmic events and may help those affected by COVID/Spike Protein exposure and pathology.

Group A of subjects 9 without complications, group B of 11 with hypertension, and group C of 7 with DM.

Given the emerging evidence that mitochondrial dysfunction, specifically electron transport chain dysfunction, may play a role in the surge of observed sudden cardiac deaths in athletes, performers and pilots, a preventive and therapeutic agent would be of great use. I propose the supplementation of CoQ10 as a possible therapeutic to fill this need.

First, let us review what CoQ10 is and what it does.

Coenzyme Q-10 (CoQ-10 or Ubiquinone) is a naturally occurring quinone that is found in most aerobic organisms from bacteria to mammals. It was first identified in 1940, and isolated from the mitochondria of the beef heart, in 1957. Coenzyme Q10 is also known as Coenzyme Q, CoQ, CoQ10, Ubiquinone, Ubiquinone-Q10, Ubidecarenone, or Vitamin Q10. The various types of Coenzyme Q can be distinguished by the number of isoprenoid side-chains they have. The most common Coenzyme Q in human mitochondria is CoQ10. The 10 refers to the number of isoprene repeats. CoQ10 is ubiquitous in human tissues, although its level is variable. The level of CoQ10 is the highest in organs with high rates of metabolism such as the heart, kidney, and liver (114, 66.5, and 54.9g/g tissue, respectively), where it functions as an energy transfer molecule. The primary biochemical action of CoQ10 is as a cofactor in the electron-transport chain, in the series of redox reactions that are involved in the synthesis of adenosine triphosphate. As most cellular functions are dependent on an adequate supply of Adenosine triphosphate (ATP), CoQ10 is essential for the health of virtually all human tissues and organs.

Antioxidants, such as CoQ10, can neutralize free radicals and may reduce or even help prevent some of the damage they cause. CoQ10 improves energy, augments the immune system, and acts as an antioxidant. The potential use of coenzyme Q10 supplements alone or in combination with other drug therapies and nutritional supplements may help prevent or treat some of the following conditions: cardiovascular diseases, high blood pressure, cancer, periodontal diseases, mitochondrial disorders, radiation injury, obesity, diabetes, Parkinson's disease, acquired immune deficiency syndrome (AIDS), gastric ulcers, allergy, migraine headaches, kidney failure, muscular dystrophy, and aging. CoQ10 plays a significant role in boosting the immune system and physical performance, as tissues and cells involved with immune function are highly energy-dependent and therefore require an adequate supply of CoQ10 for optimal function.

Coenzyme Q10: The essential nutrient
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178961/

Immediately we can see how CoQ10 would be very beneficial to those suffering from COVID, Long COVID and Spike Protein pathologies. Please review the bolded conditions above that it helps to prevent and treat.

There is another benefit that it has which is of critical important given the surge in Sudden Cardiac Deaths, especially in the young, healthy and active. In particular, athletes, performers and pilots have been seen dropping of “heart attacks” of late. Don’t let the term “heart attack” confuse you. Most people think of the elderly individual who has clogged arteries succumbing to a complete blockage resulting in the classic “heart attack.” However, it is far more likely that young, healthy and active individuals are far more likely to have a heart rhythm abnormality, known as an arrhythmia, be the cause of their Sudden Death due to a “heart attack.”

As has been demonstrated in a previous post, the Spike Protein damages the Mitochondria, which impairs the Electron Transport Chain. This is a biological process within the Mitochondria that generates ATP, or cellular energy. A disruption in this process can cause fatal arrythmias.

In summary, we found that RAS activation resulted in mitochondrial injury, mitochondrial ROS production, reduction in Cx43, and increased arrhythmic risk. These changes were ameliorated by a mitochondria-targeted antioxidant but not agents targeted to other sources of cardiac oxidation or a general antioxidant. These results establish that ROS can be arrhythmogenic and elucidate a possible mechanism, whereby ROS can cause arrhythmia.

Mitochondria Oxidative Stress, Connexin43 Remodeling, and Sudden Arrhythmic Death
https://www.ahajournals.org/doi/10.1161/CIRCEP.112.976787

A Japanese study, quoted in the initial graphic, demonstrated that, indeed CoQ10 significantly reduced Ventricular Premature Beats, a common arrythmia.

In this investigation the effect of CoQ10 on VPBs was considered beneficial in 6 (22%) of 27 patients ; 1 from group B with hypertension and 5 from group C with DM. Further, in 4 out of 6 patients, VPBs improved with respect to severity. Even in 2 patients from group C who failed to meet the criteria for drug effect evaluation, the frequency of VPBs was reduced by 50% or more. The mean reduction of VPBs frequency in the 5 responders plus these 2 patients was 85.7%. This was statistically significant as compared to the values obtained in the other two groups. These findings provide suggestive evidence that CoQ10 exhibits an effective antiarrhythmic action not merely on organic heart diseases but also on VPBs supervening on DM.

Antiarrhythmic Action of Coenzyme Q10
https://www.jstage.jst.go.jp/article/tjem1920/141/Suppl/141_Suppl_453/_pdf

Furthermore, CoQ10 has been shown to reduce the risk of arrythmias during recovery from heart surgery. Why do I believe this is significant? Because the Spike Protein damages the heart in ways similar to heart surgery and transplantation in that its function is reduced and it is damaged by free radicals.

Clinical research indicates that introducing CoQ10 prior to heart surgery, including bypass surgery and heart transplantation, can reduce damage caused by free radicals, strengthen heart function, and lower the incidence of irregular heart beat (arrhythmias) during the recovery phase. You should not take any supplements before surgery unless your provider approves.

Coenzyme Q10
https://www.mountsinai.org/health-library/supplement/coenzyme-q10#

While additional research is certainly needed, I believe there is enough evidence to show that CoQ10 supplementation may help individuals prone to Sudden Cardiac Death due to acute COVID infection and recovery, Long COVID and Spike Protein exposure.

The above is a work of medical research and is not medical advice. Always consult your Primary Care Provider before using any supplement or medication.

Thank you for your support and readership. I will continue to unravel the mechanisms of SARS-CoV-2 and its Spike Protein. I will also continue to seek treatments and methods of prevention. I wish everyone a safe, joyous and blessed weekend.