"The elderly KiSel-10 Study participants (age range: 70 – 88 years) were given 200 milligrams of Coenzyme Q10 (2 times 100 milligrams at different times) and 200 micrograms of organic selenium yeast or matching placebos daily for four years. One of the main results from the study was a significant reduction in cardiovascular mortality. In this sub-analysis, Professor Alehagen and his team of researchers found significantly lower levels of von Willebrand factor and plasminogen activator inhibitor-1 in the active treatment group as compared to the placebo group. They interpreted these outcomes as an indication that the intervention had improved endothelial function. The better endothelial function may be one of the mechanisms by which the combination of selenium and CoQ10 supplements results in significantly reduced cardiovascular mortality."
My former husband, a fighter pilot, then an airline pilot took Coenzyme Q10, Melatonin and Selenium ACE daily 40 years ago! He was fanatical about always having a supply!
Agree 100% Walter albeit in my humble (but readily admitted non-Ph.D) opinion ;) Those supplements that complement the intracellular ATP process so well aided by CoQ10 (some were lightly touched upon by a few of us yesterday, NR/NMN, PQQ, etc) would warrant consideration as well. Thanks once again for your excellent work...
I’ve taken CoQ10 for years since I’m on a statin. I have a ventricular arrhythmia (not dangerous, just annoying) that acts up periodically. I also have 40-60% blockage in my widow maker. Not sure this stuff works.
article - "Cough Suppressant Knocks Some Hearts Back into Rhythm" - study published in "nature cardiovascular research" "Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome"
this stops my "pvc" so far so good, 30 mg of dextromethorphan worked within a couple of hours, for the 3ed time in a row now, over the last few months, to stop skipped beats every 2 or 3 or 5 beats with very strong pulse and strong feeling of malaise that would have? by experience have continued longer and reoccurred over a number of days before quieting for a time then to repeat. .
I bought "equate" Mucus Relief DM from walmart for its 60 mg of dextromethorphan cough suppressant, (and guaifenesin expectorant within a timed release pill) WITHOUT RED DIE content and to stock my "covid" times kit. I use the kitchen micro plane, that I use to puree garlic for medicinal use, to grate 1/2 of the pill into a cup, add water, dissolve for a bit and drink. I only needed 1 dose to stop the skipped beats with very strong pulse and strong feeling of malaise in 2 hours or so. So I did not take any continuing daily doses. note: I bought the 14 pill bottle which provided 28 doses. This has worked for me to stop each episode and now into my second bottle GREATLY increase the time between episodes.
from the study "The results indicated that the dosing strategy for dextromethorphan used in the study achieved a stable increase in plasma dextromethorphan levels throughout the day (Extended Data Fig. 8a), with the plasma level of dextromethorphan in treated animals being comparable to dextromethorphan levels in human participants taking 30 mg dextromethorphan per day for 7 d"
my note: with the added "half life" of previous doses the sustained level in the blood over 7 day daily dosing is most likely higher than what is obtained from a single 30mg dose, depending on half life.
6? years ago something happened? (Now thinking it was "hidden" heart damage set off at the same time as a full body, 3 week long non itching rash that started near the end of a course of antibiotics taken for a tooth ache after finding out antibiotics can cause heart damage note; I was never given any explanation for what I was told were "pvc".). Long periods of daily skipped beats which prompted an internist visit then month long monitoring that recorded some of the occurrences I reported using the monitor, they did call to check if I was OK after a bad session of skipped beats then cardiologist but nothing was going on then all "ok" including a 0 buildup calcium score heart scan. then 1 urgent care visit with active "pvc" to get print out for cardiologist. PVCs? NO HELP RECEIVED
Better, self figured out, self care reduced frequency of occurrence over the years. So far so good for dextromethorphan hydrobromide.
SVT would really worry me. Seems like a cardiologist or even an internist would be able to answer your "wondering". Or at least caution if there is a established reason not to try it. According to wickedpedia "At doses 11 to 75 times the recommended therapeutic dose" for dextromethorphan tachycardia is a listed adverse event. All this tells me is do not take too much. Searching using duckduckgo with "dextromethorphan and svt" ect - little to nothing
I got no help with what I was told were PVC. I would feel really "off" then realize my heart was "skipping beats" and having palpitations. I did not accept that this was something that I should not be concerned about. The study was showing effect in QT syndrome nothing in my reading of the study stuck with me about using it for other heart rhythm problems. I tried it because with its over the counter status the risk was low and if it helped the benefit was high. What it would so with SVT I have no idea.
Essentially yes. Arrhythmia pertains to abnormal rythm and a premature ventricular contraction would qualify. I think most of us have them naturally from time to time.
Thankyou, Walter. Am going to pass this on to my vx injured friend.
"The elderly KiSel-10 Study participants (age range: 70 – 88 years) were given 200 milligrams of Coenzyme Q10 (2 times 100 milligrams at different times) and 200 micrograms of organic selenium yeast or matching placebos daily for four years. One of the main results from the study was a significant reduction in cardiovascular mortality. In this sub-analysis, Professor Alehagen and his team of researchers found significantly lower levels of von Willebrand factor and plasminogen activator inhibitor-1 in the active treatment group as compared to the placebo group. They interpreted these outcomes as an indication that the intervention had improved endothelial function. The better endothelial function may be one of the mechanisms by which the combination of selenium and CoQ10 supplements results in significantly reduced cardiovascular mortality."
I heard that ubiquinol metabolizes into COQ10 at maybe 10X the effectiveness. True? Not true? Walter?
Info here:
https://wmcresearch.substack.com/p/draining-the-batteries-the-spike/comments
My former husband, a fighter pilot, then an airline pilot took Coenzyme Q10, Melatonin and Selenium ACE daily 40 years ago! He was fanatical about always having a supply!
Thank you so much! I’ve been taking Ubiquinol--your article tells me I’m on the right track.
Interesting article. Thank you.
Agree 100% Walter albeit in my humble (but readily admitted non-Ph.D) opinion ;) Those supplements that complement the intracellular ATP process so well aided by CoQ10 (some were lightly touched upon by a few of us yesterday, NR/NMN, PQQ, etc) would warrant consideration as well. Thanks once again for your excellent work...
❤️😘Walter … have a great weekend.
My respect 🙏
Search "mitochondrial cocktail" to get suggested treatments.
I’ve taken CoQ10 for years since I’m on a statin. I have a ventricular arrhythmia (not dangerous, just annoying) that acts up periodically. I also have 40-60% blockage in my widow maker. Not sure this stuff works.
article - "Cough Suppressant Knocks Some Hearts Back into Rhythm" - study published in "nature cardiovascular research" "Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome"
this stops my "pvc" so far so good, 30 mg of dextromethorphan worked within a couple of hours, for the 3ed time in a row now, over the last few months, to stop skipped beats every 2 or 3 or 5 beats with very strong pulse and strong feeling of malaise that would have? by experience have continued longer and reoccurred over a number of days before quieting for a time then to repeat. .
I bought "equate" Mucus Relief DM from walmart for its 60 mg of dextromethorphan cough suppressant, (and guaifenesin expectorant within a timed release pill) WITHOUT RED DIE content and to stock my "covid" times kit. I use the kitchen micro plane, that I use to puree garlic for medicinal use, to grate 1/2 of the pill into a cup, add water, dissolve for a bit and drink. I only needed 1 dose to stop the skipped beats with very strong pulse and strong feeling of malaise in 2 hours or so. So I did not take any continuing daily doses. note: I bought the 14 pill bottle which provided 28 doses. This has worked for me to stop each episode and now into my second bottle GREATLY increase the time between episodes.
from the study "The results indicated that the dosing strategy for dextromethorphan used in the study achieved a stable increase in plasma dextromethorphan levels throughout the day (Extended Data Fig. 8a), with the plasma level of dextromethorphan in treated animals being comparable to dextromethorphan levels in human participants taking 30 mg dextromethorphan per day for 7 d"
my note: with the added "half life" of previous doses the sustained level in the blood over 7 day daily dosing is most likely higher than what is obtained from a single 30mg dose, depending on half life.
6? years ago something happened? (Now thinking it was "hidden" heart damage set off at the same time as a full body, 3 week long non itching rash that started near the end of a course of antibiotics taken for a tooth ache after finding out antibiotics can cause heart damage note; I was never given any explanation for what I was told were "pvc".). Long periods of daily skipped beats which prompted an internist visit then month long monitoring that recorded some of the occurrences I reported using the monitor, they did call to check if I was OK after a bad session of skipped beats then cardiologist but nothing was going on then all "ok" including a 0 buildup calcium score heart scan. then 1 urgent care visit with active "pvc" to get print out for cardiologist. PVCs? NO HELP RECEIVED
Better, self figured out, self care reduced frequency of occurrence over the years. So far so good for dextromethorphan hydrobromide.
Wow, thank you for sharing your independent research. My 28 year old son is having SVT and I’m wondering if this could help him.
SVT would really worry me. Seems like a cardiologist or even an internist would be able to answer your "wondering". Or at least caution if there is a established reason not to try it. According to wickedpedia "At doses 11 to 75 times the recommended therapeutic dose" for dextromethorphan tachycardia is a listed adverse event. All this tells me is do not take too much. Searching using duckduckgo with "dextromethorphan and svt" ect - little to nothing
I got no help with what I was told were PVC. I would feel really "off" then realize my heart was "skipping beats" and having palpitations. I did not accept that this was something that I should not be concerned about. The study was showing effect in QT syndrome nothing in my reading of the study stuck with me about using it for other heart rhythm problems. I tried it because with its over the counter status the risk was low and if it helped the benefit was high. What it would so with SVT I have no idea.
Essentially yes. Arrhythmia pertains to abnormal rythm and a premature ventricular contraction would qualify. I think most of us have them naturally from time to time.