Friday Hope: Back to Basics: Vitamin C and the Tumor Microenvironment: Especially in Combination with Fasting-Mimicking Diet
Friday Hope: Back to Basics: Vitamin C and the Tumor Microenvironment: Especially in Combination with Fasting-Mimicking Diet
Evidence to support why intravenous Vitamin C has been shown to be effective against SARS-CoV-2 and its Spike Protein.
Underlying mechanisms of Vitamin C targeting the specialized tumor microenvironments. The interplay between tumor cells and the TME promotes an aggressive phenotype in various ways, including immune tolerance, metabolic reprogramming, angiogenesis, and tumor innervation. Vitamin C (VitC) with multi-targeted effects may reverse the tumor-promoting microenvironments, displaying a wide range of anticancer activities.
Let me first pose a question: Is SARS-CoV-2 and its Spike Protein a chimeric virus and protein INTENDED to be used as an experimental model of oncogenesis?
One of the most important aspects of being a proficient chess player, is being able to change your strategy as the position on the board evolves during the course of a game. I believe research must be conducted in a similar fashion. This is why I am willing to let go of my Spike Protein Endothelial Disease (SPED) hypothesis as I see it becoming a Spike Protein Tumor Microenvironment Disease (SP-TED) hypothesis. The more we peel back the layers of this onion, the more evidence I see supporting this framework over just an Endothelial disease.
On this subject, I decided to research compounds which early on were found to be effective against COVID, and if they are also effective against the Tumor Microenvironment. If you read my previous post, you will see how Ivermectin is effective against the Tumor Microenvironment. Well, so is Vitamin C.
I ask all who have the time to please read this superb paper which details how Vitamin C is effective against the Tumor Microenvironment (TME). However, what completely blew me away, was that IN COMBINATION THERAPY Vitamin C appears to be even more effective. And, this is in combination with METFORMIN and FASTING MIMICKING DIETING! All of these have been found to be effective against COVID and the Spike Protein!
Regarding nutrition and metabolism, several studies have attempted to explore IVC with nutritional therapy in cancer patients. Fasting-mimicking diet and ketogenic diet postpone tumor progression by depleting glucose in TME and improving immunity. Di Tano et al. demonstrated that fasting-mimicking diet and VitC treatment exerted a synergistic effect on oxidative damage and chemotherapy-induced cytotoxicity in KRAS-mutant tumors. In another study, patients who received IVC after ketogenic therapy had increased levels of ketone bodies and reduced generalized inflammation compared to pretreatment. Despite the encouraging results, the safety of this calorie restriction strategy remains disputable, considering cancer patients often experience malnutrition and increased energy expenditure.
Repurposing Vitamin C for Cancer Treatment: Focus on Targeting the Tumor Microenvironment
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9179307/
While I find this encouraging, I am also deeply distressed. Are we dealing with something that was designed to induce cancer in an experimental setting? Again, is this why China was so draconian in trying to stop its spread. Although, even China has now realized that you cannot stop the spread of anything as transmissible as the Omicron and post-Omicron variants of SARS-CoV-2.
Let’s keep moving forward with open minds. Always seeking to understand what the evidence shows, and to only follow that evidence.
Your support and kindness are what keeps me going. Blessings to all in this Holiday Season.
And yet again thank you. We seem to be thinking down very similar lines, from a mildly different perspective though? Is your background in medicine or research? My first career I am a biochemist by trade, with expertise and cell biology as well as protein structure and function. i’m thinking you must be in the same neighborhood.
My early days of this Covid misadventure were how to mitigate the risk of the virus, and detoxify from spike protein. I knew I was going to be exposed, including from people excreting exosomes (I will state that, from an observational standpoint, knowing it is not backed by solid research.... Yet.), since I interact with so many people per week.
I was under the impression I was doing reasonably with that until I was diagnosed with breast cancer (“aggressive,” which more literally means fast growing) in July. i’m 49, absolutely no family history, never had an abnormal mammogram before. So I have to ask the question, did spike protein from a mild infection play a part in this? Or repeated exposure from folks who had just had the shots? if so, what does that mean for her to move forward?
And so I went exploring, as we brainiacs do, to find ways I could help my body. Your post yesterday about ivermectin hit home, from both the covered angle and the cancer angle. I agree the tumor microenvironment is a very important consideration - and that became an exploration for me, from a personal level.  I opted in for intravenous vitamin C prior to radiation, then I had another round of Intravenous vitamin C after I got Covid during radiation (lolz, yes of course that was fun)  and at this point I am considering intermittent fasting in January (already predominantly keto).
One thing I would love your take on is whether there may be a potential role of modified citrus pectin or  mushroom extract (Turkey tail, chaga) for the medicinal properties of their small molecules. as always, dose would be one unknown entity. But whether these may be helpful on a widespread basis, in theory.
I believe I have the same fear as you, that this little bioweapon has an underlying purpose that will rear its ugly head in time. Or perhaps it already has begun to.

Apologies for typos. Dictation.
Linus Pauling would be happy to see you writing about his favorite topic ! Please don’t abandon the endothelial sped theory. I believe there are many pathways and mechanisms involved with the spike protein as a consequence of the jab. Thanks for your work .