37 Comments

Walter - keep the research and analysis coming.

As for this stack, I’d suggest focusing more on lowering insulin resistance as a deeper root cause for fighting COVID or more likely just rebalancing the immune system to improve general overall health.

To lower insulin resistance:

1- Lower dietary carbohydrates

2- Consider Fasting regimens such as Intermittent Fasting/Time Restricted Feeding

3- Increase activity/exercise

4- Improved sleep quality and circadian cycles

Metformin can help but the lifestyle hacks above do it naturally.

I like to focus my substack blog on diet and lifestyle choices for improved health.

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Nov 26, 2022Liked by Walter M Chesnut

Thank you Walter. I hope you had a nice Thanksgiving. I am thankful for you and all your tireless work. Thank you.

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Nov 26, 2022Liked by Walter M Chesnut

Walter, when are you coming to Montreal, i have some interesting data we can discuss after a few games of blitz? :-)

"Artemisinin protects endothelial function and vasodilation from oxidative damage via activation of PI3K/Akt/eNOS pathway"

https://www.sciencedirect.com/science/article/abs/pii/S0531556521000450

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WALTER!!!!! 📢 GET BACK ON TWITTER NOW!!!

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Berberine comes to mind as a non-pharma option: https://pubmed.ncbi.nlm.nih.gov/36183284/ and https://pubmed.ncbi.nlm.nih.gov/19800084/

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Nov 26, 2022Liked by Walter M Chesnut

Fascinating.

One caveat: Metformin blocks B12 uptake and, IMO, this is one of the reasons so many Type II diabetics develop peripheral neuropathy. Of course, most of these folks are also on statins which have their own set of side effects (actually increase DMII about 38%)... Anyway, I advise patients who are on long term metformin to obtain monthly B12 injections - forever.

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I was going to review Galega officinalis as an antiviral but it drops your blood sugar too well!

Galega is the parent of Metformin. What else does it do? Aids lactation in goats!

Effects of Medications to Treat Diabetes on Milk Supply

Given the potential role of insulin resistance in low milk production, metformin has been proposed as a galactogogue. Metformin is a derivative of guanidine, one of the metabolically active compounds in Galega officinalis, or goat’s rue. Goat’s rue is so-named because it increases milk production in goats.

https://www.sciencedirect.com/topics/medicine-and-dentistry/galega-officinalis

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Interesting idea, but metformin has been touted as a wonder drug for many things over the time and not necessarily delivered, unfortunately. It was part an arm of the now discredited TOGETHER trial

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Nov 26, 2022Liked by Walter M Chesnut

Excellent news!

Thank you, Walter. Have a wonderful holiday.

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Thank you. A friend of mine started this med after being diagnosed with diabetes but stopped b/c it causes digestive issues not wanted by most unfortunately. Berberine could be a natural alternative?

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Metformin also seems to be effective to starve certain cancer pathways.

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This is very interesting since it is the only drug ever endorsed by Life Extension. It seems to have a benefit as to keeping cancers at bay as well. It would be interesting if it might undo clotting?

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If Metformin works, wouldn't Berberine work just as well? As a non pharma option?

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Has anyone heard of Berberine also having anti-cancer properties?

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Would berberine do the same?

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