Possible oncogenic effects of SARS-CoV-2 infection on different organs
Worldwide clinicians are witnessing a sustained, unprecedented spike in early onset cancers. However, it should be noted that this rise has been taking place since 1990. Furthermore, though cases of cancer have increased, mortality has slightly declined.
Global incidence of early-onset cancer increased by 79.1% and the number of early-onset cancer deaths increased by 27.7% between 1990 and 2019. Early-onset breast, tracheal, bronchus and lung, stomach and colorectal cancers showed the highest mortality and DALYs in 2019.
Our study showed that the global morbidity of early-onset cancer increased from 1990 to 2019, while mortality and DALYs slightly decreased. The rate of incidence, mortality and DALY varied widely across regions, countries and cancer types. The highest-burden regions and cancer types were high-middle and middle SDI regions and early-onset breast cancer, TBL cancer, CRC and stomach cancer, respectively. Dietary risk factors, alcohol use and tobacco consumption were the main risk factors for top early-onset cancers in 2019.
Global trends in incidence, death, burden and risk factors of early-onset cancer from 1990 to 2019
https://bmjoncology.bmj.com/content/2/1/e000049
This year, for the first time, over 2,000,000 cancer diagnoses are expected to be made in the USA.
Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths in the United States and compiles the most recent data on population-based cancer occurrence and outcomes using incidence data collected by central cancer registries (through 2020) and mortality data collected by the National Center for Health Statistics (through 2021). In 2024, 2,001,140 new cancer cases and 611,720 cancer deaths are projected to occur in the United States.
Cancer statistics, 2024
https://acsjournals.onlinelibrary.wiley.com/doi/10.3322/caac.21820
Into this milieu of rapidly increasing cancer diagnoses steps SARS-CoV-2. It may indeed be a contributing factor to this year’s projected record number of cases. And, it may foreshadow those numbers increasing more dramatically. It has become apparent that SARS-CoV-2 has multiple mechanisms to induce cancers – in multiple organs.
This is yet another example of how broadly SARS-CoV-2 can damage the body. Remember, HIV targets CD4 cells. Due to the ACE2 receptor, SARS-CoV-2 targets virtually every cell.
The major route of entry for the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) into human host cells is by means of the angiotensin-converting enzyme-2 (ACE2) transmembrane receptor. This zinc-containing carboxypeptidase and membrane-integral surface receptor is ubiquitous and widely expressed in multiple cell types.
Ubiquity of the SARS-CoV-2 receptor ACE2 and upregulation in limbic regions of Alzheimer's disease brain
https://pubmed.ncbi.nlm.nih.gov/34628788/
Viruses have been known to cause cancers. The first, and ostensibly the most famous, is Rous Sarcoma Virus. However, it induces only one type of cancer.
Peyton Rous wasn’t expecting a chicken to show up in his laboratory one day in 1909. But there she was, a barred Plymouth Rock hen with a bright red comb, clucking amidst the Bunsen burners.
The chicken’s owner, a poultry farmer from Long Island, had noticed a lump protruding from the bird’s right breast. Concerned that she might sicken other members of his flock, the farmer turned to Dr. Rous for help.
A pathologist at the Rockefeller Institute in New York City, Dr. Rous was known for having an interest in cancer. He took a biopsy of the lump and found it to be a sarcoma, a type of cancer that affects muscle or bone tissue. What he did next changed the course of cancer treatment.
Dr. Rous cut off a piece of the tumor, ground it up, and passed it through a filter to remove all cells. Then he injected this cell-free liquid into other chickens. Within a few weeks, they too developed tumors.
And then this discovery.
The rediscovery of Dr. Rous’s work in the 1960s led researchers to ask what it was about the virus that enabled it to cause cancer. From early experiments, they knew that every cell in the chicken tumor contained the Rous sarcoma virus.
How a Chicken Helped Solve the Mystery of Cancer
https://www.mskcc.org/news/how-chicken-helped-solve-mystery
The above provides us with two issues to deal with. What kind of cancer(s) may be induced, and are viral particles present in those cancers?
Whereas Rous Sarcoma Virus only induced Sarcomas, SARS-CoV-2 has the ability to induce cancer in multiple organs via multiple mechanisms. The ACE2 entry way (among others) is a major reason why so many organs may be affected. Please refer to the illustration at the beginning of the post.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has shown diverse life-threatening effects, most of which are considered short-term. In addition to its short-term effects, which has claimed many millions of lives since 2019, the long-term complications of this virus are still under investigation. Similar to many oncogenic viruses, it has been hypothesized that SARS-CoV-2 employs various strategies to cause cancer in different organs. These include leveraging the renin angiotensin system, altering tumor suppressing pathways by means of its nonstructural proteins, and triggering inflammatory cascades by enhancing cytokine production in the form of a “cytokine storm” paving the way for the emergence of cancer stem cells in target organs. Since infection with SARS-CoV-2 occurs in several organs either directly or indirectly, it is expected that cancer stem cells may develop in multiple organs.
Additionally, and a point I have made from the beginning, that of viral persistence, may exacerbate the oncogenic properties of SARS-CoV-2.
The long-term impact of COVID-19 on morbidity and mortality cannot be neglected. Experimental studies show that SARS-CoV-2 is able to induce re-infection/reactivation and persistent infection in the same manner as seen with other viral infections. One of the most worrying long-term effects of infection is the potential to induce malignant neoplasms, which will be a major health concern over the coming decades. SARS-CoV-2 infection affects many mechanisms that play a crucial role in cancer onset and progression including cell cycle regulation, the RAAS system and inflammation/proliferation signaling pathways.
It would be very beneficial if new tumors could be screened for SARS-CoV-2 viral particles or RNA. Clearly not every tumor would be caused by SARS-CoV-2, yet there may be a subset that has a SARS-CoV-2 viral fingerprint.
Thank you, as always, for your readership, dialog, and support.
I note careful non- mention of any gene therapy injections! All possible causes have not been investigated!
The huge rise in cancer and turbo cancer is because of the bioweapon jabs. Not a nonexistent “virus” that has never been isolated by anyone anywhere.