Is Spike Protein Endothelial Disease (SPED) Actually Part of a More Complex Process? Spike Protein “Metastasis?”

Just As Cancer Does, the Spike Protein Spreads to Create Tumor Microenvironments (TME), Which Can Induce Tumors

The biological processes affected by COVID-19. The graph shows numbers of biological processes identified in the COVID-19 network. An astounding number were found to be hallmarks of Cancer.

The nonmalignant cells in the TME often play a protumorigenic function at all phases of carcinogenesis by stimulating uncontrolled cell proliferation. The TME comprises different cellular components. The first is endothelial cells, which play a key role in tumor development and tumor cell protection from the immune system. The second major component is immune cells, such as granulocytes, lymphocytes, and macrophages. These cells are involved in various immune responses and activities, such as inflammatory reactions orchestrated by the tumor to promote survival. The most prominent immune cell type in the TME is the macrophage. Macrophages have diverse functions that are linked to cancer development and progression; they promote the escape of tumor cells into the circulatory system and can suppress antitumor immune mechanisms and responses. The final cell type in the TME is the fibroblast. Fibroblasts allow cancer cells to migrate from the primary tumor location into the bloodstream for systemic metastasis.

Tumor Microenvironment
https://www.mdpi.com/1648-9144/56/1/15

We know all too well how the Spike Protein affects the Endothelium, but what about the other major players in the Tumor Microenvironment? Let’s first look at Macrophages.

Innate immunity triggers responsible for viral control or hyperinflammation in COVID-19 are largely unknown. Here we show that the SARS-CoV-2 spike protein (S-protein) primes inflammasome formation and release of mature interleukin-1β (IL-1β) in macrophages derived from COVID-19 patients but not in macrophages from healthy SARS-CoV-2 naïve individuals.

Long-lived macrophage reprogramming drives spike protein-mediated inflammasome activation in COVID-19
https://www.embopress.org/doi/full/10.15252/emmm.202114150

Just as in a tumor, the Spike Protein primes macrophages to release mature interleukin-1β. Astounding!

Within a tumor, IL-1β is produced and secreted by various cell types, such as immune cells, fibroblasts, or cancer cells. The IL1B gene is induced after “priming” of the cells and a second signal is required to allow IL-1β maturation by inflammasome-activated caspase-1. IL-1β is then released and leads to transcription of target genes through its ligation with IL-1R1 on target cells.

Interleukin-1β and Cancer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408158/

With regard to the Fibroblasts, it is almost certain that the Spike Protein is activating them, as it binds to Integrins and activates TGF-β. There may also be more direct fibroblast activation which we have not yet discovered.

The SARS-CoV-2 spike protein contains an RGD integrin-binding domain close to the ACE2 binding region, which could potentially facilitate binding to RGD-binding integrins, which includes several TGF-β -activating integrins.

COVID-19 and pulmonary fibrosis: A potential role for lung epithelial cells and fibroblasts
https://onlinelibrary.wiley.com/doi/full/10.1111/imr.12977

And the above mechanism is how we reach the activated fibroblasts required for the TME.

Integrin–TGF-β crosstalk in fibrosis

Fibrosis results from an aberrant response to organ injury and is characterized by the proliferation of fibroblasts, their differentiation into myofibroblasts, and excessive ECM production and deposition; these processes are all mediated by TGF-β.

Integrin–TGF-β crosstalk in fibrosis, cancer and wound healing
https://www.embopress.org/doi/full/10.1038/embor.2009.276

Of course, if the infection is stopped in the respiratory or digestive tracts, the Spike Protein does not reach the bloodstream to spread to distal locations. If the Spike Protein is released directly into the bloodstream…

I am beginning to suspect that the Spike Protein’s SPED is a massively accelerated METATASTIC ENGINE which can induce TME throughout the body, priming it for tumorigenesis and the activation of latent tumors.