Friday Hope: Melatonin Supresses Catecholamine Synthesis
Melatonin may be an effective therapeutic in reducing SPED and COVID catecholamine storms.
I would like to bring to everyone’s attention a very good paper which demonstrates how Melatonin reduces the synthesis of catecholamines. As endothelial cells are able to synthesize catecholamines, Melatonin may prove to be an effective therapeutic in supressing the observed catecholamine storms in COVID and SPED.
Melatonin treatment significantly reduced the mRNA expression of catecholamine synthases, including the rate-limiting enzyme tyrosine hydroxylase (Th), 3,4-dihydroxyphenylalanine decarboxylase and dopamine-β-hydroxylase expressed in PC12 cells.
Melatonin regulates catecholamine biosynthesis by modulating bone morphogenetic protein and glucocorticoid actions
https://www.sciencedirect.com/science/article/abs/pii/S0960076016301728#
Friday Hope: Melatonin Supresses Catecholamine Synthesis
I'm looking forward to Friday for more than Malone's "Friday Funnies" LOL. I've been using melatonin for a long time so no problem there. It's been on the protocols over at flccc.net so I wonder if this is the pathway (or one of) that it works? Great catch Walt.
Thank you. After another day of vascular surgery mishaps I’ll gladly take some melatonin tonight. God speed.