Confirmation of My 2021 Hypothesis that the Spike Protein Induces Accelerated Aging

A paper published June 9th confirms the findings. This is an incredible danger of repeated exposure to the Spike Protein.

In November 2021, I published a post on X demonstrating how the Spike Protein of SARS-CoV-2 induces all nine Hallmarks of Aging as defined in the classic paper by Carlos López-Otín et al. I had formed the hypothesis in early 2021, by November enough had been published to prove it in theory. The paper published yesterday proves it in fact.

Here is my post from November 2021:

HALLMARKS OF AGING AND THE SPIKE
https://wmcresearch.org/hallmarks-of-aging-and-the-spike/

The findings published yesterday focus on two of the nine Hallmarks of Aging that the Spike Protein induces. Those are Epigenetic Alterations by Methylation and Telomere Attrition. Let’s first look at DNA methylation.

A study conducted by Mongelli et al. determined the Biological Age (bAge) of 117 individuals who had recovered from COVID-19 (referred to as post-COVID-19) and 144 healthy participants using pyrosequencing focusing on CpG islands that have previously been identified as reliable indicators of bAge developed by Beckaert et al. The results indicate an increase in bAge among the post-COVID-19 group with an acceleration of DeltaAge by approximately 5.25 years, beyond the normal range (26, 46).

The calculated EAA showed a significant DNAm age acceleration across different clocks including Horvath, Hannum, PhenoAge, and GrimAge clocks in severe COVID-19 patients (48). Similarly, non-severe COVID-19 cases exhibited significant DNAm age acceleration in the Horvath, Hannum, skin&blood, and GrimAge clocks. Further analysis of epigenetic age dynamic acceleration across each COVID-19 disease phase revealed an acceleration from the initial phase, which was partly reversed in later phase.

The impact of COVID-19 on “biological aging”
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1399676/full

As I wrote in November 2021, the Spike Protein induces this:

Viral Protein: Spike protein        
Host Machinery: ACE2R             
Epigenetic Change: Methylation at CpG site

An immune epigenetic insight to COVID-19 infection
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7958646/

The other aspect of biological aging that yesterday’s paper focused on is Telomere Shortening.

In a prospective study, telomere length in hospitalized COVID-19 patients revealed a significantly higher proportion of COVID-19 patients with shorter telomeres when compared to the control cohort. Telomere attrition was associated with a higher risk of critical disease, defined as admission to the intensive care unit (ICU) or death without ICU (59). In another study on COVID-19 survivors, significant telomere shortening was observed following absolute human telomere length measurement (26). A similar finding was reported by Sanchez-Vazquez et al. where telomeres in severe COVID-19 cases were observed to be shorter than those in patients with mild COVID-19 symptoms (53, 60).

The impact of COVID-19 on “biological aging”
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1399676/full

Once again, as I wrote in November 2021, the Spike Protein alone induces Telomere Shortening.

We predict that S2 spike RNA treated AEC2 will produce less telomerase activity in this peak of 24h. The reduction in the activity can be quantified with G-quadruplex-intercalating porphyrin telomerase inhibitor. Further, the telomerase activity can also be quantified with PCR based Telomere Repeat Amplification Protocol (TRAP).

Sars-Cov2 Spike and Telomerase RNA’s Compared to Arrive at an Explanation for Increased Ageing in Alveolar Cells in Severe COVID-19
https://www.walshmedicalmedia.com/open-access/sarscov2-spike-and-telomerase-rnas-compared-to-arrive-at-an-explanation-for-increased-ageing-in-alveolar-cells-in-severe.pdf

What concerns me is that the forest is not being seen – only the trees. Isn’t it clear? Repeated exposures to the Spike Protein will almost certainly continually induce these effects. Three exposures? Thank you very much for fifteen years of your life! Capisce?

If there is a silver lining in all of this, it is that since we understood the fundamentals correctly here, it is much more likely that the therapeutics we have been discussing are perhaps more likely to ameliorate these conditions. I will keep working. As always, Thank You. I cannot do this without your support.