It has been established that the Spike Protein of SARS-CoV-2 induces amyloidosis and fibrils. Yet, is the appearance of amyloids just one of the pathologies it can induce?
https://medicalxpress.com/news/2022-05-discovery-mechanism-mysterious-covid-symptoms.html
Let us consider the findings of fibrin blood clots in patients reporting to the emergency room and in the bodies of the deceased as discovered by embalmers:
Amyloid Beta INDUCES THE FORMATION OF ABNORMAL, DEGRADATION-RESISTANT BLOOD CLOTS. This is paramount in Alzheimer’s Disease (AD).
The association between Aβ and fibrinogen causes altered fibrin clotting, and this aberrant hemostasis could lead to compromised blood flow and increased inflammation, thereby contributing to cognitive decline in AD.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895773/
VARIATIONS ON A THEME
Of course, one could argue that Alzheimer’s itself is a VASCULAR DISEASE. This very same mechanism – infiltration of blood vessels with an amyloid protein and eventually the organs themselves – can be induced in every organ. It appears that this is occurring.
It makes sense that the endothelium would be the canary in this coalmine. It is the largest organ in the body and the “road” to all other organs.
https://www.ahajournals.org/doi/10.1161/01.str.0000014421.15948.67
What is most fascinating is that results from a study indicated that exogenous Aβ seeds from different Aβ pathologies induced Aβ deposition in the blood vessels rather than the brain parenchyma without being influenced by Aβ strain-specific information, which might be why CAA is a predominant feature of Aβ pathology in iatrogenic transmission cases.
https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-021-01252-0
Is that not, by definition, what the Spike Protein is? An Aβ seed from a different Aβ pathology? And is it not inducing “Aβ” deposition in the blood vessels?
In a study of Long COVID patients, the following was determined: There was evidence of mild organ impairment in the heart (32% of patients), lungs (33%), kidneys (12%), liver (10%), pancreas (17%), and spleen (6%). And, surprisingly: “Causality of the relationship between organ impairment and infection cannot be deduced, but may be addressed by longitudinal follow-up of individuals with organ impairment,” the authors said.
https://www.bmj.com/content/371/bmj.m4470
However, they are certainly wrong. We absolutely can deduce the causal relationship between organ impairment and infection: it is the amyloid infiltration of the Spike Protein into those organs.
THE DEAD REVEAL HOW THE LION STALKS ITS PREY
If we review autopsies of those who died from COVID-19, there was a finding that gave pause to the researchers. The authors mention the finding casually, yet they have no idea how significant it actually is.
“This post-mortem study showed several histopathological abnormalities in COVID-19 non-survivors; however, none of the findings was specific for direct viral injury, even though SARS-CoV-2 was detected in all examined organs using RT-PCR.”
And this is the point. Those who are not immediately killed by SARS-CoV-2 have, literally, the seeds of destruction sowed in their bodies.
https://ccforum.biomedcentral.com/articles/10.1186/s13054-020-03218-5
For those who have been following my work, this fits precisely with the accelerated aging I (and others) observed related to SARS-CoV-2 infection.
https://www.francesoir.fr/opinions-tribunes/le-sars-cov2-accelererait-lage-biologique
So, we come full circle. Please read this sentence and contemplate it well:
It is known that hypertension, atherosclerosis and amyloidosis can be viewed as accelerated aging.
https://www.frontiersin.org/articles/10.3389/fgene.2017.00126/full
Questions to be addressed:
Are the Spike Protein “amyloid seeds” distributed throughout the organs of the infected (and transfected) lying in wait, to be activated by “The heart-ache and the thousand natural shocks that flesh is heir to?” Greatly accelerating any affliction that we experience?
Does the presence of these Spike Proteins mean that Inflammaging is the result of SARS-CoV-2 infection, due to their ability, as a superantigen, to create excessive cytokines?
Are these effects cumulative? With each exposure to the Spike Protein?
Can the Spike Protein be eradicated from the body?
Can the damage done be ameliorated, or reversed?
There is much still to learn.
The cases of Covid long that I know of have been both vaccinated and contaminated so exposure to spike is perhaps and probably cumulative. I miss you on Twitter Walter
Thank you, dear Walter, for shining such a steady, bright light into these dark areas. These are such excellent questions and such a marvelous overview of where we now find ourselves, two years into this pandemic. There is a fascinating diagram/graphic on this "Elementary Immunology" text, in Chapter 33, Amyloidosis, that describes some "amyloidosis signs and symptoms" including: Heart Arrythemias; Heart Sudden Death; Thyroid Medullary Carcinoma; Stomach Undifferentiated Carcinoma; Spleen Spenomegaly; Pancreas Islet Tumor; Kidneys Renal Failure; Kidneys Nephrotic syndrome; GIT Constipation; GIT Diarrhea; and GIT Malabsorption. Here's a link to this information: https://labpedia.net/elementary-immunology/chapter-33-amyloidosis/
I am feeling much more optimistic about all this now than I was this time a year ago, since I am a recovered covid longhauler who now am about 11 months free from longhaul symptoms and relapses. In order to recover, I adopted healing strategies addressing a Niacin connection; an MCAS connection (minimizing histamine food), and also taking anti-inflammatory, anti-amyloid practices and supplements. I originally caught what must have been covid-19 the last week of January 2020, and by July 2021 was relapse and symptom free--after doing everything I could to get better in a dedicated 90 day program of minimum heat/stress/exertion to give my nonclassical monocytes a chance to regenerate free from any viral debris.
It seems to me that even in this past year of seemingly being recovered I've actually still been recovering--since although I was relapse and symptom free, each week and month I was noticing my vocabulary getting better, and my joints and ligaments seeming more solid (my ankles used to randomly collapse).
We are wise to not underestimate covid, and from what we're seeing in the Salk Institute spike protein study, all that's needed to cause serious issues is just the spike protein--and indeed, it seems to exert cumulative destructive effects.