A Prion Disease of the Body: The Spike Protein as Proteopathic Seed

The presence of vacuoles in tissue at autopsy is a most disturbing finding.

My research has gone back to its roots. I initially viewed the Spike Protein as an inducer of Prion disease. However, I was only focused on the Brain and was not seeing results that would indicate that Prion disease was a major element of Spike Protein pathology.

Yet, if you start to look at other organs, an extremely disturbing picture begins to emerge. We find the hallmark of Prion disease – vacuoles. And they are EVERYWHERE. In virtually EVERY organ – including the reproductive organs.

I believe we must now look at COVID as a PRION disease with an ACUTE phase and a CHRONIC phase. Very, very much like HIV.

First, let us look at the proteopathic properties of the Spike.

Protein aggregates associated with neurodegenerative diseases have the ability to transmit to unaffected cells, thereby templating their own aberrant conformation onto soluble homotypic proteins. Proteopathic seeds can be released into the extracellular space, secreted in association with extracellular vesicles (EV) or exchanged by direct cell-to-cell contact.

Using different cellular models propagating prions or pathogenic Tau aggregates, we demonstrate that vesicular stomatitis virus glycoprotein and SARS-CoV-2 spike S increase aggregate induction by cell contact or ligand-decorated EV.

Highly efficient intercellular spreading of protein misfolding mediated by viral ligand-receptor interactions
https://www.nature.com/articles/s41467-021-25855-2

Vacuolation is perhaps the most defining hallmark of Prion Disease. Except here, it is not just the brain. The Spike becomes an Infectious Protein IN ALL ORGANS!

On vacuolation and Prion Disease:

The initial vacuolation could be an adaptive cellular response to compartmentalize the increase in pathogenic prion isoforms, while an excessive accumulation of pathologic prion isoforms in later stages represents the inability of the cell to continue to compartmentalize these misfolded proteins in vacuoles.

Prion channel proteins and their role in vacuolation and neurodegenerative diseases
https://pubmed.ncbi.nlm.nih.gov/12202918/

Now, let us look at autopsy reports.

LIVER

Although coronavirus particles or viral inclusions were not detected in the liver tissues for all cases, vacuolar degenerations in hepatocytes, edematous of mitochondria with the disruption of cristae, and expansions of the endoplasmic reticulum were observed.

Liver Histopathological Analysis of 24 Postmortem Findings of Patients With COVID-19 in China
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8543004/

KIDNEY

Several abnormalities have been identified in the kidney tissue of deceased patients with AKI and COVID-19, mostly diffuse acute tubular injury (ATI) with cytoplasmic vacuoles.

Association between Postmortem Kidney Biopsy Findings and Acute Kidney Injury from Patients with SARS-CoV-2 (COVID-19)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259494/

HEART

Myocardium is edematous and small blood vessels are congested. The CMC exhibit multifocal vacuolar degenerative changes. No inflammatory cellular infiltrates are present.

COVID-19: a Disease with a Potpourri of Histopathologic Findings—a Literature Review and Comparison to the Closely Related SARS and MERS
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8354305/

TESTES

In hACE2 transgenic mice, numerous large vacuoles were observed in the seminiferous tubules at 3 days postinfection.

Infection of SARS-CoV-2 causes severe pathological changes in mouse testis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724560/

BRAIN

Edema was identified in 5 cases (perivascular scarce neuropil, forming “vacuoles”), exudation of fibrin and hemosiderin (meaning that an extravascular leak of red cells has occurred, days before the death).

Postmortem brain 7T MRI with minimally invasive pathological correlation in deceased COVID-19 subjects
https://insightsimaging.springeropen.com/articles/10.1186/s13244-021-01144-w

We must look into this extremely deeply. So many questions. Everything from “What is a fatal Spike Load?” to “How do we (if at all) degrade the Spike Protein in vivo?”

Also, more research needs to be completed to specifically confirm this hypothesis.

I cannot thank you enough for your support. We have a wonderful, thoughtful and caring community. I will continue working.