WMC Research

Share this post

A PARRALEL BETWEEN JUVENILE RHEUMATOID ARTHRITIS (JRA) AND THE SPIKE PROTEIN

wmcresearch.substack.com

A PARRALEL BETWEEN JUVENILE RHEUMATOID ARTHRITIS (JRA) AND THE SPIKE PROTEIN

IS THE BODY ATTACKING ITS OWN ENDOTHELIUM?

Walter M Chesnut
Mar 4, 2022
13
Share

An interesting case (published in 1989) discussed in the Journal of Pediatric Gastroenterology and Nutrition relays a case in which a JRA patient developed a fatal immune enteropathy years after the onset of the disease. Biopsies of the small bowel exposed to the patient's serum revealed deposition of complement and immunoglobulins in the epithelium.

This is where the parallel with COVID (in particular, the Spike Protein) becomes apparent. Multiple-Organ Complement Deposition on Vascular Endothelium is observed in COVID-19 Patients. Additionally, AFTER infection with COVID-19, convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation.

What does this suggest?

I believe that the incredibly strong binding affinity for the Spike Protein to endothelial cells via ACE2 is causing an autoimmune response. What we may be observing is the body attacking and destroying its own endothelium. This would explain the EXTREME endothelial damage being observed. It is not JUST the invading pathogen, but the body itself joins forces to destroy the body’s own vasculature.

Evidence suggesting this mechanism can be found in other, related diseases. Antiendothelial cell antibodies (AECA) are a heterogeneous family of antibodies reacting with endothelial cell antigens. These antibodies are found in various diseases and recognise several antigen determinants. Different pathophysiological effects have been observed in in vitro experiments, which include direct or indirect cytotoxicity and endothelial cell apoptosis. Furthermore, some AECA activate endothelial cells, resulting in increased leucocyte adhesiveness, activation of coagulation and vascular thrombosis.

PRECISELY what is being observed in COVID and in reactions to the Spike Protein.

I believe we are observing FATAL IMMUNE VASCULOPATHY related to Kawasaki Disease and therefore MIS-C.

Screening for AECA must be done immediately.

Referenced/Related Papers

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC1798473/

https://elifesciences.org/articles/64909

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8394811/

https://pubmed.ncbi.nlm.nih.gov/11414746/

https://journals.lww.com/jpgn/Abstract/1989/02000/Fatal_Multisystem_Disease_with_Immune_Enteropathy.22.aspx

13
Share
Comments
Top
New
Community

No posts

Ready for more?

© 2023 Walter M Chesnut
Privacy ∙ Terms ∙ Collection notice
Start WritingGet the app
Substack is the home for great writing