A Global Demyelination Epidemic?

SARS-CoV-2, Mouse Hepatitis Virus, Long COVID and Sudden Deaths

The puzzle of Long COVID has held the world captive now for almost three years. I personally believe it is a great disservice to science and to those suffering from Long COVID that the condition is not being discussed publicly. Nor is its widespread prevalence being acknowledged in any meaningful manner by world and national health organizations.

Following the course of my previous work, the readers of my Substack know that I believe the Spike Protein is an invasive proteopathic seed capable of cellular disruption, destruction and inducing prionopathies.

If we look at Mouse Hepatitis Virus (also a coronavirus) there is another aspect of the Spike’s invasive capabilities that becomes readily apparent.

Studies employing recombinant viruses with a modified spike (S) glycoprotein of MHV-JHM have identified the S gene as a major determinant of neurovirulence.

Pathogenesis of acute and chronic central nervous system infection with variants of mouse hepatitis virus, strain JHM
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090838/

Perhaps the most disturbing outcome of this neurovirulence is the induction of a chronic demyelinating disease. The pathogenesis of this demyelinating disease fits hand-in-glove with SARS-CoV-2.

Partially protective anti-viral immune responses may result in persistent infection and chronic demyelinating disease characterized by myelin removal from axons of the CNS and associated with dense macrophage/microglial infiltration. Demyelinating disease during MHV-JHM infection is immune-mediated, as mice that lack T lymphocytes fail to develop disease despite succumbing to encephalitis with high levels of infectious virus in the CNS. However, the presence of T lymphocytes or anti-viral antibody can induce disease in infected immunodeficient mice. The mechanisms by which these immune effectors induce demyelination share an ability to activate and recruit macrophages and microglia, thus increasing the putative role of these cells in myelin destruction.

Pathogenesis of acute and chronic central nervous system infection with variants of mouse hepatitis virus, strain JHM
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090838/

Let’s break this down. The first highlight needs no comment.

Partially protective anti-viral immune responses may result in persistent infection and chronic demyelinating disease…

Equally, if not more disturbing is the fact that THE ANTIBODIES TO SARS-COV-2 (SPIKE) THEMSELVES can induce disease. The paper claims that this happens in immunodeficient mice. However, this is SARS-CoV-2 and we must determine if immunodeficiency is still “required.” However, I do not believe it is as THE SPIKE PROTEIN OF SARS-COV-2 ITSELF ACTIVATES MICROGLIA.

Role of SARS-CoV-2 Spike-Protein-Induced Activation of Microglia and Mast Cells in the Pathogenesis of Neuro-COVID
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10001285/

As early as two years ago, it was observed that the immune response to SARS-CoV-2 can induce demyelination. So, I am almost certain it is occurring. Likely even in asymptomatic cases.

Demyelination as a result of an immune response in patients with COVID-19
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088756/

If one thinks of Long COVID, demyelination should immediately come to mind.

Mood and thinking

There may be changes in mood associated with demyelination, such as many experiencing depression, anxiety, and irritability.

There may also be problems with thinking such as memory issues and a loss of focus, with some taking longer to process their thoughts.

Blood pressure and heart

In some cases, demyelination may result in people having poorer control over their blood pressure, as well as having a racing heartbeat or palpitations with no apparent cause.

Demyelination: Symptoms, Causes, Diagnosis, Treatment
https://www.simplypsychology.org/demyelination.html

Additionally, demyelination may be the cause for the non-acute myocarditis sudden deaths.

These two examples may sound all too familiar.

A diagnosis of Multiple sclerosis and a differential of Neuromyelitis Optica Spectrum of Disorder were being considered. She was scheduled a clinic appointment to discuss diagnosis and treatment options. No treatment had been commenced yet. However, she developed sudden onset of shortness of breath while at home and died in the ambulance on the way to the hospital.

Our working diagnosis was Multiple sclerosis with a differential diagnosis of Neuromyelitis Opitica Spectrum of Disorder. We could not associate her peripheral neuropathy to any other disorder. She developed sudden onset of shortness of breath and was admitted to a hospital closer to her residence. The patient developed cardiorespiratory arrest and died after a failed resuscitation.

Sudden Death in Demyelinating Disorders
https://medcraveonline.com/JNSK/sudden-death-in-demyelinating-disorders.html

The invasive Spike Protein is indeed inducing partially protective antibodies. Given the overwhelming similarities to MHV, I believe we must endeavor to discover if, indeed, we are in the midst of a catastrophic global demyelination epidemic.